Protein Alignment clt and cest-25

DIOPT Version :10

• Sequence 1: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_497609.1
• Gene: cest-25 / 175390
• WormBaseID: WBGene00022178
• Length: 550
• Species: Caenorhabditis elegans
• Alignment Length: 554
• Identity: 159/554 - (28%)
• Similarity: 244/554 - (44%)
• Gaps: 100/554 - (18%)

  Fly     5 PCGRLIFTRFCSSMKVKVPVKQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERF 69
            |..|.:.|.:            |.:.||:.......:.::|.|:|||.||:|.|||..|:|.|::
 Worm    14 PPSRQVLTSY------------GPIEGRRLIHEGEKQVDAFQGIPYAAPPIGNLRFALPQPHEKW 66

  Fly    70 QKQELDCSKEGNVSYQRD----PFTLEVAGSEDCLFLNVYAPK-VKSTRTPLPVMVWIHGGGFFF 129
            .:.. :....|....|:|    |.|  ...|||.|.||::.|. .....|..||:::||||||..
 Worm    67 TEVR-ETKSFGARGIQKDHVLSPKT--SPQSEDNLTLNIFTPVWTPKNETGFPVILYIHGGGFVS 128

  Fly   130 GNGN--SDFHFPAKLMEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASF 192
            .:.:  .|......|:.::|:|||:.||||.|||.:..:..|..|:.|.|...||:||:|||..|
 Worm   129 DSAHKYGDMSICQHLVTKDVVVVTIQYRLGFLGFWTTGDSSIPDNVALHDMVFALKWVKENIGLF 193

  Fly   193 NGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAKTRRLAELLGG 257
            ||||||:||.|:||||:||...:.:..::.||.|.|...|.|:..|..........|..|:.:
 Worm   194 NGDPNNITLMGQSAGGASVDFLSISPVSRDLFQKVIPMGGNASCSWAIHPRPLNACRNRAQEI-- 256

  Fly   258 GDFGGDSKALLTFLQSEKATPTAILANTLKVLSPDERRRHLP---FAF---KPVVEDSSSPD--- 313
            |.|.|                    .|||..:   |:.|.||   ||.   ...|:..:.|:
 Worm   257 GVFDG--------------------MNTLDWV---EKLRELPADKFASALNMEAVDTKTDPELLI 298

  Fly   314 ------RFLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAIV---VKAKQKLEAYEDDLARLVPRN 369
                  .|:.:.:|||  :|:. ...|.::|...:|||...   :..|..|.|.:.|::.::...
 Worm   299 GPKYDNLFIPRPVMEL--RKEA-PMKPRLLGCAKSEGLVFAFFGLNTKHPLHAVQQDVSAILSEK 360

  Fly   370 LVLDPQAPEAQEAASDIRAFFFNGQALSKENMDN-LVDLFSDYHFSMDLQRAVEIHASCQTQSPL 433
            | ...:|.:.||.|  :......|...|||.... :|||..|...::.:|:.|......|..:|:
 Worm   361 L-FPLKARDYQEKA--LEKLIEIGTDHSKEEWQRAMVDLKGDSFLNVGIQQNVLDVLETQPSTPI 422

  Fly   434 YFYRLDYVG----GRNLYKKIFQNEDLRGVAHADDICYLFQMAGDET----EMNRDDLMVTERLC 490
            |.|..||..    |...:|..|::     ..|..||.|   :.|:..    :.|.:|..:.|...
 Worm   423 YMYSFDYCNPKAYGIMGFKLPFKD-----ATHCTDISY---VVGNHIVNSFDFNEEDYKMIEITT 479

  Fly   491 EMWANFARDGKPS----------PIWKP--VKKP 512
            .:|.|||:.|.|:          ..|:|  ::.|
 Worm   480 RLWTNFAKYGNPNGEGDDVAHLEEKWEPATIESP 513

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	156/537 (29%)
cest-25	NP_497609.1	COesterase	15..536	CDD:395084	158/553 (29%)