DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and cest-27

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_871861.2	Gene:	cest-27 / 171610	WormBaseID:	WBGene00018958	Length:	561	Species:	Caenorhabditis elegans

Alignment Length:	567	Identity:	170/567 - (29%)
Similarity:	264/567 - (46%)	Gaps:	76/567 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    23 PVKQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSYQRD 87
            |:|.   ||.:::  :|.....|||:||||||:|.|||:.| ...|...:.|||.:.|..|.|.|
Worm    34 PIKG---VGYEQE--DGSVVEGFLGIPYAEPPIGALRFKKP-VAHRKWTEPLDCVRFGPRSPQND 92

  Fly    88 ----PFTLEVAGSED-CLFLNVYAPKVKSTRTP--LPVMVWIHGGGFFFGNGNSDF---HFPAKL 142
                .|...|..||: ||.|||:.||.:|...|  .||||:||||||.. :.:|::   .....|
Worm    93 ELLGQFVNTVGKSEEHCLSLNVFTPKWESNEWPDGFPVMVFIHGGGFAV-HSSSNYGCASIARNL 156

  Fly   143 MEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAG 207
            ..::|:|||:|||||.|||.:..:|...||:||.||..|||||||||.||.|||:|||:||:|||
Worm   157 CTKDVVVVTINYRLGVLGFFTTGDEVCRGNLGLWDQTAALEWVQENIQSFRGDPDNVTIFGQSAG 221

  Fly   208 GSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQ-NEAPAK-TRRLAELLGGGDFGGDSKALLTF 270
            |:||.|...:.|::.||::||..:|....::..: :|..|: :|..|..||......||:.||.|
Worm   222 GASVDLLCLSPHSRGLFNRAIPMAGNGECDFAMRTSEQQAQLSREFARYLGWEGDDNDSEDLLQF 286

  Fly   271 LQSEKATPTAILANTLKVLSPDERRRHL---PFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLGS 332
            :..:.      |......::|....:|.   ...|.|..:..     |..:.:.:|  :|:. ..
Worm   287 IDQQP------LYKIEMGINPKRGFKHSQAGSLYFVPNFDGD-----FFPKPLNQL--RKEA-PK 337

  Fly   333 MPVIMGYNSAEGLAIVVKAKQKLEAYEDDLARLVPRNLVLDPQAPEAQEAASDIRAFFFNG--QA 395
            |.::.|....|||..:  |...|....:.:.:.:.|..........|.:....:..|:|.|  ..
Worm   338 MQIMTGTTKYEGLFFI--ALGALSKNPEGIKKFMGRIFKECDYGERADDVLQMVYDFYFKGVHPK 400

  Fly   396 LSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDY--VGGRNLYKKIFQNEDLRG 458
            ..::||..:|....||..:....|...|  ....|..:|||:.||  ..|..:::.:.   ...|
Worm   401 DHEKNMHQIVKFIGDYSINYGTYRLANI--MTDLQHDVYFYQFDYHNSAGFGVFRWLL---PFLG 460

  Fly   459 VAHADDICYLFQMAG----DETEMNRDDLMVTERLCEMWANFARDGKP------SPIWKPVKKPH 513
            ..|..::.|:.   |    .:...|.:|..:...:...:.|||:.|.|      :..|:.....|
Worm   461 STHCTEMRYVL---GKGIISKFRPNDNDKKMLHVMTTYFTNFAKYGNPNGENQETGEWQKHDSAH 522

  Fly   514 NGEPIQLDCLLIDRELKMCSNPDGERMDFWRSMYRRYRSENFEAVRA 560
            .....::|   :|         |.|.::    .|:..|:|.::.:||
Worm   523 PFRHFKID---LD---------DSEMVE----DYQERRAELWDKLRA 553

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	165/548 (30%)
cest-27	NP_871861.2	COesterase	29..541	CDD:278561	165/553 (30%)
cest-27	NP_871861.2	Aes	<114..>283	CDD:223730	76/169 (45%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	1	1.000	-	-		otm14771
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X33
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920