Protein Alignment clt and Ces3b

DIOPT Version :9

• Sequence 1: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_653094.2
• Gene: Ces3b / 13909
• MGIID: 3644960
• Length: 571
• Species: Mus musculus
• Alignment Length: 619
• Identity: 163/619 - (26%)
• Similarity: 255/619 - (41%)
• Gaps: 129/619 - (20%)

  Fly     6 CGRLIFTRFCSSMKV---KVPVKQGVLVGRQ------KKLVNGLEYNSFLGVPYAEPPVGELRFR 61
            |..|.|....:..||   :|....|.:.|||      .::|     |.|||:|:|:.|||.|||.
Mouse    20 CLLLAFVTTVTGPKVIQPEVDTPLGRVRGRQVGVKDTDRMV-----NVFLGIPFAQAPVGPLRFS 79

  Fly    62 SPRPLERFQ---------------KQELDCSKEG-NVSYQRDPFTLEVAGSEDCLFLNVYAPKVK 110
            :|.|.:.::               .:::..|:.| |...:..|.      |||||.||:|:|...
Mouse    80 APLPPQPWEGVRDASINPPMCLQDVEKMINSRFGLNEKIKIFPI------SEDCLTLNIYSPTEI 138

  Fly   111 STRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGL 175
            :.....|||||||||....|:..|. ...|.....:|:|||:.||||..||||..::.:.||.|.
Mouse   139 TAGDKRPVMVWIHGGSLLVGSSTSQ-DGSALAAYGDVVVVTVQYRLGIFGFLSTGDKHMPGNRGF 202

  Fly   176 KDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSG---TANME 237
            .|...||.|||.|||.|.||||.||:||.||||..|.....:..:..|||:||.|||   |..||
Mouse   203 LDVVAALRWVQGNIAPFGGDPNCVTIFGNSAGGMIVSSLFLSPISAGLFHRAISQSGIVTTIMME 267

  Fly   238 ----WVFQNEAPAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTLKVLSPD-ERRRH 297
                |       .:.:..|..:..|                .|:|..::...|:....| .::::
Mouse   268 DMKPW-------PEAQNFANSVACG----------------SASPAELVQCLLQKEGKDLIKQKN 309

  Fly   298 LPFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEAYE--- 359
            :..::  :|.||..|.|      .|.:.......::|.::|..:.|...:::|:...|:..|
Mouse   310 VNISY--IVNDSFFPQR------PEKLLADQQFPTVPYLLGVTNHEFGWLLLKSLNILDKLEHLS 366

  Fly   360 -DDLARLVPRNLVLDPQAPEAQEAASDIRAFFFNGQALS------KENMDNLVDLFSDYHFSMDL 417
             :||..:....|.:....||......|  .:..||...|      :|.:.::..:....:||..|
Mouse   367 REDLLEISRPFLAIMEVPPEIMPTVID--EYLDNGSDQSATRYAFQELLGDISFIIPTLNFSKYL 429

  Fly   418 QRAVEIHASCQTQSPLYFYRLDYV-GGRNLYKKIFQNEDLRGVAHADDICYLF--QMAGDET--- 476
            :     .|.|    |::.|...:. .....:|..:...|     ||.:..::|  ....||:
Mouse   430 R-----DAGC----PVFLYEFQHTPSSFAKFKPAWVKAD-----HASENSFVFGGPFLTDESSLL 480

  Fly   477 ---EMNRDDLMVTERLCEMWANFARDGKPS----PIWKPVKKPHNGEPIQLDCLL-IDRELKMCS 533
               |...::..::..:...|:.|||.|.|:    |.|..:.        ||:..| |..|.:...
Mouse   481 AFPEATEEEKQLSLTMMAQWSQFARTGNPNGKGLPPWPQLN--------QLEQYLEIGLESRTGV 537

  Fly   534 NPDGERMDFW-----RSMYRRYRSENFEAVRAKL 562
            .....|:.||     |.:...:|.:....|..:|
Mouse   538 KLKKGRLQFWTETLPRKIQEWHREQRSRKVPEEL 571

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	152/574 (26%)
Ces3b	NP_653094.2	COesterase	36..547	CDD:278561	152/577 (26%)
		Aes	75..>245	CDD:223730	68/176 (39%)
		Prevents secretion from ER. /evidence=ECO:0000255	568..571		0/2 (0%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	5.910