DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and Ces1g

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_067431.2	Gene:	Ces1g / 12623	MGIID:	88378	Length:	565	Species:	Mus musculus

Alignment Length:	572	Identity:	168/572 - (29%)
Similarity:	239/572 - (41%)	Gaps:	129/572 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    45 FLGVPYAEPPVGELRFRSPRPLE--RFQKQELDCSKEGNVSYQRDPFTLEVAG------------ 95
            |||||:|:||:|.|||..|.|.|  .|.|.   .:....:.||.....|.:|.
Mouse    50 FLGVPFAKPPLGSLRFAPPEPAEPWSFVKH---TTSYPPLCYQNPEAALRLAELFTNQRKIIPHK 111

  Fly    96 -SEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQEVIVVTLNYRLGAL 159
             |||||:||:|.|...:..:.|||||||||||... :|.|.:......:.:.|:||.:.||||..
Mouse   112 FSEDCLYLNIYTPADLTQNSRLPVMVWIHGGGLVI-DGASTYDGVPLAVHENVVVVVIQYRLGIW 175

  Fly   160 GFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLF 224
            ||.|..:|...||.|..||..||.|||:|||:|.|:|.:||:|||||||.||.:...:..||.||
Mouse   176 GFFSTEDEHSRGNWGHLDQVAALHWVQDNIANFGGNPGSVTIFGESAGGESVSVLVLSPLAKNLF 240

  Fly   225 HKAIMQSGTANMEWVFQNEAPAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTLKVL 289
            |:||.||.......:|...|....:::|.|.|.                 |.|.:|.:.:.|:..
Mouse   241 HRAIAQSSVIFNPCLFGRAARPLAKKIAALAGC-----------------KTTTSAAMVHCLRQK 288

  Fly   290 SPDE------------------RRRHLPFAFKPVVEDS----SSPDRFLEQDIMELMHKKDCLGS 332
            :.||                  .|...||.  |.|.|.    .:|:        |::.:|. ..:
Mouse   289 TEDELLEVSLKMKFGTVDFLGDPRESYPFL--PTVIDGVLLPKAPE--------EILAEKS-FNT 342

  Fly   333 MPVIMGYNSAE-GLAIVV---------KAKQKLEAYEDDLARLVPRNLVLDPQAPEAQEAASDIR 387
            :|.::|.|..| |..|.:         |..||..|  ..|.:..|...:.:...|.|.|.
Mouse   343 VPYMVGINKHEFGWIIPMFLDFPLSERKLDQKTAA--SILWQAYPILNISEKLIPAAIEK----- 400

  Fly   388 AFFFNGQALSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNLYKKIFQ 452
              :..|........|..:||..|..|.:........|.  ...:|.|.|...|   |..:....:
Mouse   401 --YLGGTEDPATMTDLFLDLIGDIMFGVPSVIVSRSHR--DAGAPTYMYEYQY---RPSFVSDDR 458

  Fly   453 NEDLRGVAHADDICYLFQMAG--------DETEMNRDDLMVTERLCEMWANFARDGKPS----PI 505
            .::|.| .|||:   ||.:.|        .|.|:|     :::.:.:.||||||:|.|:    |.
Mouse   459 PQELLG-DHADE---LFSVWGAPFLKEGASEEEIN-----LSKMVMKFWANFARNGNPNGEGLPH 514

  Fly   506 WKPVKKPHN----GEPIQLDCLLIDRELKMCSNPDGERMDFWRSMYRRYRSE 553
            |....:...    |.|.|....|.|:|           :|||..:..:..:|
Mouse   515 WPEYDQKEGYLQIGVPAQAAHRLKDKE-----------VDFWTELRAKETAE 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	165/560 (29%)
Ces1g	NP_067431.2	COesterase	24..545	CDD:278561	165/560 (29%)
Ces1g	NP_067431.2	Aes	<121..>239	CDD:223730	55/118 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	6.920