DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and Bche

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_011238302.1	Gene:	Bche / 12038	MGIID:	894278	Length:	615	Species:	Mus musculus

Alignment Length:	578	Identity:	170/578 - (29%)
Similarity:	260/578 - (44%)	Gaps:	109/578 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VPVKQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSYQR 86
            :..|.|.:.|....::.| ...:|||:|||:||:|.|||:.|:||.::.... :.::..|..||.
Mouse    47 ITTKTGRVRGLSMPVLGG-TVTAFLGIPYAQPPLGSLRFKKPQPLNKWPDIH-NATQYANSCYQN 109

  Fly    87 -----------DPFTLEVAGSEDCLFLNVYAPKVKSTRTPLP----VMVWIHGGGFFFGNGN--- 133
                       :.:......|||||:|||:.|      .|.|    |||||:||||..|..:
Mouse   110 IDQAFPGFQGSEMWNPNTNLSEDCLYLNVWIP------VPKPKNATVMVWIYGGGFQTGTSSLPV 168

  Fly   134 SDFHFPAKLMEQEVIVVTLNYRLGALGFLSLP-EEGIHGNMGLKDQRLALEWVQENIASFNGDPN 197
            .|..|.|::  :.||||::|||:||||||:.| .....|||||.||:|||:|||.|||:|.|:|.
Mouse   169 YDGKFLARV--ERVIVVSMNYRVGALGFLAFPGNPDAPGNMGLFDQQLALQWVQRNIAAFGGNPK 231

  Fly   198 NVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAKTRRLAELLGGGDFGG 262
            ::|:||||||.:||.||.....:..||.:||::||::|..|..::...|:.|.|..    ..|.|
Mouse   232 SITIFGESAGAASVSLHLLCPQSYPLFTRAILESGSSNAPWAVKHPEEARNRTLTL----AKFTG 292

  Fly   263 DSK----ALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMEL 323
            .||    .::..|:|:  .|..||.|...||..|.   .|...|.|.|:.....|  :...:::|
Mouse   293 CSKENEMEMIKCLRSK--DPQEILRNERFVLPSDS---ILSINFGPTVDGDFLTD--MPHTLLQL 350

  Fly   324 MHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEAYEDDLARLVPRNLVLDPQAPEAQEAASDIRA 388
            ...|    ...:::|.|..||.|.:|..   ...:..|...|:.|.        |.||.   :..
Mouse   351 GKVK----KAQILVGVNKDEGTAFLVYG---APGFSKDNDSLITRK--------EFQEG---LNM 397

  Fly   389 FFFNGQALSKENM-----------------DNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFY 436
            :|.....|.||.:                 |.|.|:..||:.........:..|..:..:..||:
Mouse   398 YFPGVSRLGKEAVLFYYVDWLGEQSPEVYRDALDDVIGDYNIICPALEFTKKFAELENNAFFYFF 462

  Fly   437 -----RLDYVGGRNLYKKIFQNEDLRGVAHADDICYLFQM-AGDETEMNRDDLMVTERLCEMWAN 495
                 :|.:             .:..||.|..:|.::|.: .|......|.:.:.:..:.:.|||
Mouse   463 EHRSSKLPW-------------PEWMGVMHGYEIEFVFGLPLGRRVNYTRAEEIFSRSIMKTWAN 514

  Fly   496 FARDGKP------SPIWKPVKKPHNGEPIQLDCLLIDRELKMCSNPDGERMDFWRSMY 547
            ||:.|.|      |.:| ||......:.:.|:    ..:.|:.|.....:..|||..:
Mouse   515 FAKYGHPNGTQGNSTMW-PVFTSTEQKYLTLN----TEKSKIYSKLRAPQCQFWRLFF 567

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	167/572 (29%)
Bche	XP_011238302.1	COesterase	46..563	CDD:365897	167/572 (29%)
Bche	XP_011238302.1	AChE_tetra	578..612	CDD:370053
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S4412
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.860