Protein Alignment clt and ache

DIOPT Version :10

• Sequence 1: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_571921.1
• Gene: ache / 114549
• ZFINID: ZDB-GENE-010906-1
• Length: 634
• Species: Danio rerio
• Alignment Length: 639
• Identity: 182/639 - (28%)
• Similarity: 283/639 - (44%)
• Gaps: 154/639 - (24%)

  Fly     7 GRLIFTRFCSSMKVKVPVKQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLER--- 68
            ||:..||      :.||.:..|:              :|||:||||||:|:.||:...|.:.
Zfish    36 GRVQGTR------LPVPDRSHVI--------------AFLGIPYAEPPIGKRRFKRAEPKKPWNN 80

  Fly    69 -FQKQELD--CSKEGNVSYQRDPFTLEV-----AGSEDCLFLNVYAPKVKSTRTPLP----VMVW 121
             |:.:|..  |.:..:.||...| .:|:     ..|||||:|||:.|.     ||.|    ||||
Zfish    81 VFEAKEFSNACYQFVDTSYPGFP-GIEMWNPNRVMSEDCLYLNVWVPP-----TPRPQNLTVMVW 139

  Fly   122 IHGGGFFFGNGNSDFHFPAKL-MEQEVIVVTLNYRLGALGFLSL-PEEGIHGNMGLKDQRLALEW 184
            |:||||:.|:.:.|.:....| ..::|:||::|||:||.|||:| ......||:||.||||||:|
Zfish   140 IYGGGFYSGSSSLDVYDGRYLAYTEKVVVVSMNYRVGAFGFLALNGSSDAPGNVGLYDQRLALQW 204

  Fly   185 VQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEW--VFQNEAPAK 247
            |||||..|.|:|..||:||||||.:||.:|..:..::.||.:||:|||..|..|  |..:||..:
Zfish   205 VQENIHFFGGNPKQVTIFGESAGAASVGMHVLSPDSRPLFTRAILQSGVPNTPWATVTFDEARRR 269

  Fly   248 TRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVEDSSSP 312
            |.:|.:|: |..:|.|:: |:..|:::.  |..::....:||......|   |:|.|||:....|
Zfish   270 TTKLGKLV-GCTWGNDTE-LIDCLRNKH--PQELIDQEWQVLPWSSLFR---FSFVPVVDGVFFP 327

  Fly   313 DRFLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEAYEDDLARLVPRNLVLDP--- 374
                  |..:.|..........:::|.|..||...::..   ...:..|...|:.|...|:.
Zfish   328 ------DTPDAMISSGNFKYTQILLGVNQDEGSYFLLYG---APGFSKDNESLISREDFLESVKM 383

  Fly   375 QAPEAQEAASDIRAFFF-------NGQALSKENMDNLVDLFSD-------YHFSMDLQRAVEIHA 425
            ..|.|.:...:.....:       |||    :|.|.:.|:..|       .||:....:...:||
Zfish   384 GVPHANDIGLEAVILQYTDWMDENNGQ----KNRDAMDDIVGDQNVICPLQHFAKSYAQYAALHA 444

  Fly   426 SCQTQSP---------------------LYFYRLDYVGGRNLYKKIFQNEDLRGVAHADDICYLF 469
            .....:|                     :|.|..|:......:      .:..||.|..:|.::|
Zfish   445 QSSAAAPGTLGWGNSGPTGYNSGNSHGAVYLYLFDHRASNLAW------PEWMGVIHGYEIEFVF 503

  Fly   470 QM--------AGDETEMNRDDLMVTERLCEMWANFARDGKPS-------------PIWKPVKKPH 513
            .:        ..:|.:::|       |:...||||||.|.|:             |.:...::.|
Zfish   504 GLPLEKRLNYTAEEEKLSR-------RIMRYWANFARTGNPNVNTDGTMDSRRRWPQFSANEQKH 561

  Fly   514 ---NGEPIQLD-------CLLIDRELKMCSN-----PDGERMDFWRSMYRRYRS 552
               |.||:::.       |.|.:|.|....|     .|.||.  |:..:.|:.|
Zfish   562 VGLNTEPMKVHKGLRTQFCALWNRFLPRLLNITDNIDDVERQ--WKVEFHRWSS 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	alpha/beta hydrolases	22..543	CDD:473884	175/613 (29%)
ache	NP_571921.1	COesterase	27..583	CDD:395084	172/605 (28%)
		AChE_tetra	598..631	CDD:430146	6/18 (33%)