DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clt and Ache

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_036020624.1	Gene:	Ache / 11423	MGIID:	87876	Length:	616	Species:	Mus musculus

Alignment Length:	531	Identity:	174/531 - (32%)
Similarity:	257/531 - (48%)	Gaps:	82/531 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 VPVKQGVLVGRQKKLVNGLEYNSFLGVPYAEPPVGELRFRSPRPLERFQKQELDCSKEGNVSYQR 86
            |.|:.|.|.|.:.|...| ..::|||:|:||||||..||..|.| :|.....||.:...||.||.
Mouse    41 VRVRGGQLRGIRLKAPGG-PVSAFLGIPFAEPPVGSRRFMPPEP-KRPWSGVLDATTFQNVCYQY 103

  Fly    87 -DPFTLEVAG----------SEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPA 140
             |.......|          |||||:|||:.|..:.. :|.||::||:||||:.|..:.|.:...
Mouse   104 VDTLYPGFEGTEMWNPNRELSEDCLYLNVWTPYPRPA-SPTPVLIWIYGGGFYSGAASLDVYDGR 167

  Fly   141 KLMEQE-VIVVTLNYRLGALGFLSLP-EEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFG 203
            .|.:.| .::|::|||:|..|||:|| .....||:||.||||||:|||||||:|.|||.:|||||
Mouse   168 FLAQVEGAVLVSMNYRVGTFGFLALPGSREAPGNVGLLDQRLALQWVQENIAAFGGDPMSVTLFG 232

  Fly   204 ESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEW--VFQNEAPAKTRRLAELLG--GGDFGGDS 264
            ||||.:||.:|..:..::.|||:|::||||.|..|  |...||..:...||.|:|  .|..||:.
Mouse   233 ESAGAASVGMHILSLPSRSLFHRAVLQSGTPNGPWATVSAGEARRRATLLARLVGCPPGGAGGND 297

  Fly   265 KALLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFKPVVED---SSSPDRFLEQ-DIMELMH 325
            ..|:..|::..|..  ::.:...||..:...|   |:|.|||:.   |.:|:..:.. |..:|.
Mouse   298 TELIACLRTRPAQD--LVDHEWHVLPQESIFR---FSFVPVVDGDFLSDTPEALINTGDFQDLQ- 356

  Fly   326 KKDCLGSMPVIMGYNSAEGLAIVVKAKQKLEAYEDDLARLVPRNLVLDP---QAPEAQEAASDIR 387
                     |::|....||...:|..   :..:..|...|:.|...|..   ..|:|.:.|::..
Mouse   357 ---------VLVGVVKDEGSYFLVYG---VPGFSKDNESLISRAQFLAGVRIGVPQASDLAAEAV 409

  Fly   388 AFFFNGQALSKENMDNLVDLFS----DYHFSMDL-QRAVEIHASCQTQSPLYFYRLDYVGGRNLY 447
            ...:. ..|..|:..:|.|..|    |::....: |.|..:.|.                |..:|
Mouse   410 VLHYT-DWLHPEDPTHLRDAMSAVVGDHNVVCPVAQLAGRLAAQ----------------GARVY 457

  Fly   448 KKIFQNED-------LRGVAHADDICYLFQMAGDET-EMNRDDLMVTERLCEMWANFARDGKP-- 502
            ..||::..       ..||.|..:|.::|.:..|.: ....::.:..:||.:.|.||||.|.|
Mouse   458 AYIFEHRASTLTWPLWMGVPHGYEIEFIFGLPLDPSLNYTTEERIFAQRLMKYWTNFARTGDPND 522

  Fly   503 -----SPIWKP 508
                 ||.|.|
Mouse   523 PRDSKSPQWPP 533

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	174/531 (33%)
Ache	XP_036020624.1	COesterase	37..563	CDD:395084	174/531 (33%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910