Protein Alignment clt and CES1

DIOPT Version :9

• Sequence 1: NP_536784.1
• Gene: clt / 117300
• FlyBaseID: FBgn0000326
• Length: 562
• Species: Drosophila melanogaster
• Sequence 2: NP_001020366.1
• Gene: CES1 / 1066
• HGNCID: 1863
• Length: 568
• Species: Homo sapiens
• Alignment Length: 578
• Identity: 155/578 - (26%)
• Similarity: 244/578 - (42%)
• Gaps: 147/578 - (25%)

  Fly    45 FLGVPYAEPPVGELRFRSPRPLE--RFQK-------------------QELDCSKEGNVSYQRDP 88
            |||:|:|:||:|.|||..|:|.|  .|.|                   .||..:::.|:     |
Human    51 FLGIPFAKPPLGPLRFTPPQPAEPWSFVKNATSYPPMCTQDPKAGQLLSELFTNRKENI-----P 110

  Fly    89 FTLEVAGSEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQEVIVVTLN 153
            ..|    |||||:||:|.|...:.:..|||||||||||...| ..|.:...|....:.|:|||:.
Human   111 LKL----SEDCLYLNIYTPADLTKKNRLPVMVWIHGGGLMVG-AASTYDGLALAAHENVVVVTIQ 170

  Fly   154 YRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFAR 218
            ||||..||.|..:|...||.|..||..||.|||:|||||.|:|.:||:|||||||.||.:...:.
Human   171 YRLGIWGFFSTGDEHSRGNWGHLDQVAALRWVQDNIASFGGNPGSVTIFGESAGGESVSVLVLSP 235

  Fly   219 HAKRLFHKAIMQSGTANMEWVFQNEAPAKTRRLAELLGGGDFGGDSKAL---LTFLQSEKATPTA 280
            .||.|||:||.:||.|....:.:.                   ||.|.|   :......|.|.:|
Human   236 LAKNLFHRAISESGVALTSVLVKK-------------------GDVKPLAEQIAITAGCKTTTSA 281

  Fly   281 ILANTLKVLSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIM-ELMHKKDCLGSMPVIMGYNSAEG 344
            ::.:.|:..:.:|            :.:::...:||..|:. :....:..||:  ||.|
Human   282 VMVHCLRQKTEEE------------LLETTLKMKFLSLDLQGDPRESQPLLGT--VIDG------ 326

  Fly   345 LAIVVKAKQKLEA-------------YEDDLARLVPRNLVLDPQA-------------------- 376
             .:::|..::|:|             .:.:...|:|..|:..|.:
Human   327 -MLLLKTPEELQAERNFHTVPYMVGINKQEFGWLIPMQLMSYPLSEGQLDQKTAMSLLWKSYPLV 390

  Fly   377 -------PEAQEAASDIRAFFFNGQALSKENMDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLY 434
                   |||.|.       :..|...:.:..|..:||.:|..|.:........|.  ...:|.|
Human   391 CIAKELIPEATEK-------YLGGTDDTVKKKDLFLDLIADVMFGVPSVIVARNHR--DAGAPTY 446

  Fly   435 FYRLDYVGGRNLYKKIFQNEDLRGVAHADDICYLFQMAGDETEMNRDDLMVTERLCEMWANFARD 499
            .|...|   |..:....:.:.:.| .|.|::..:|.....:...:.:::.:::.:.:.||||||:
Human   447 MYEFQY---RPSFSSDMKPKTVIG-DHGDELFSVFGAPFLKEGASEEEIRLSKMVMKFWANFARN 507

  Fly   500 GKPS----PIWKPVKKPHN----GEPIQLDCLLIDRELKMCSNPDGERMDFWRSMYRR 549
            |.|:    |.|....:...    |...|....|.|:|:.           ||.:::.:
Human   508 GNPNGEGLPHWPEYNQKEGYLQIGANTQAAQKLKDKEVA-----------FWTNLFAK 554

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	153/570 (27%)
CES1	NP_001020366.1	COesterase	25..548	CDD:278561	153/570 (27%)
		Aes	<122..>240	CDD:223730	58/118 (49%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	216	1.000	Inparanoid score	I3612
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D206516at33208
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11559
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	7	6.970