DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and CEL

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001798.3	Gene:	CEL / 1056	HGNCID:	1848	Length:	753	Species:	Homo sapiens

Alignment Length:	571	Identity:	167/571 - (29%)
Similarity:	250/571 - (43%)	Gaps:	114/571 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    27 GVLVGRQKKL-VNGLEYNSFLGVPYAEPPVGELRFRSPRP---------LERFQKQELDCSKEGN 81
            |.:.|..||| :.|...:.|.|:|:|.|...   ..:|:|         .:.|:|:.|..:...:
Human    31 GFVEGVNKKLGLLGDSVDIFKGIPFAAPTKA---LENPQPHPGWQGTLKAKNFKKRCLQATITQD 92

  Fly    82 VSYQRDPFTLEVAGSEDCLFLNVYAPK-VKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLMEQ 145
            .:|          |.||||:||::.|: .|.....||||:||:||.|..|:|:........|.:.
Human    93 STY----------GDEDCLYLNIWVPQGRKQVSRDLPVMIWIYGGAFLMGSGHGANFLNNYLYDG 147

  Fly   146 E-------VIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFG 203
            |       |||||.|||:|.|||||..:..:.||.||:||.:|:.||:.|||:|.|||||:||||
Human   148 EEIATRGNVIVVTFNYRVGPLGFLSTGDANLPGNYGLRDQHMAIAWVKRNIAAFGGDPNNITLFG 212

  Fly   204 ESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAKTRRLAELLG--GGDFGGDSKA 266
            |||||:||.|.|.:.:.|.|..:||.|||.|...||.|.......:::||.:|  .||
Human   213 ESAGGASVSLQTLSPYNKGLIRRAISQSGVALSPWVIQKNPLFWAKKVAEKVGCPVGD------- 270

  Fly   267 LLTFLQSEKATPTAILANTLKVLSPDERRRHLPFAFK-----------------PVVEDSSSPDR 314
                        .|.:|..|||..|    |.|..|:|                 ||::..
Human   271 ------------AARMAQCLKVTDP----RALTLAYKVPLAGLEYPMLHYVGFVPVIDGD----- 314

  Fly   315 FLEQDIMELMHKKDCLGSMPVIMGYNSAEG-------LAIVVKAKQKLEAYEDDLARLVPRNLVL 372
            |:..|.:.|...   ...:..|.|.|:.:|       :..:.|..:|:.  |:|..:||....:
Human   315 FIPADPINLYAN---AADIDYIAGTNNMDGHIFASIDMPAINKGNKKVT--EEDFYKLVSEFTI- 373

  Fly   373 DPQAPEAQEAASDIRAFFFNGQALSKEN-MDNLVDLFSDYHFSMDLQRAVEIHASCQTQSPLYFY 436
             .:.....:...|:....: .|..|:|| ...:||..:|..|.:..:.|:..|.:....:..|.|
Human   374 -TKGLRGAKTTFDVYTESW-AQDPSQENKKKTVVDFETDVLFLVPTEIALAQHRANAKSAKTYAY 436

  Fly   437 RLDYVGGRNLYKKIFQNEDLRGVAHADDICYLF-QMAGDETEMNRDDLMVTERLCEMWANFARDG 500
            ...:.....:|.|..      |..|||||.|:| :.....|.....|..|::.:...|.|||:.|
Human   437 LFSHPSRMPVYPKWV------GADHADDIQYVFGKPFATPTGYRPQDRTVSKAMIAYWTNFAKTG 495

  Fly   501 KPS------PI-WKPVKKPHNGEPIQLDCLLIDRELKMCSNPDGERMDFWR 544
            .|:      |. |:|....::|      .|.|.:::...|.....|.:|.|
Human   496 DPNMGDSAVPTHWEPYTTENSG------YLEITKKMGSSSMKRSLRTNFLR 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	165/568 (29%)
CEL	NP_001798.3	Heparin-binding	21..121		28/102 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	555..753
		17 X 11 AA tandem repeats, glycodomain, O-linked (mucin type)	559..745
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000017
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810