DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment clt and Ces2

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	NP_001258232.1	Gene:	Ces2 / 100910144	RGDID:	6504334	Length:	561	Species:	Rattus norvegicus

Alignment Length:	543	Identity:	165/543 - (30%)
Similarity:	259/543 - (47%)	Gaps:	102/543 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 NSFLGVPYAEPPVGELRFRSPRPLERFQ------------KQELDCSKEGNVSYQRDPFTLEVAG 95
            ::|||:|:|:||||.|||..|.|.|.:.            .|.||...|..: .........::.
  Rat    58 HTFLGIPFAKPPVGPLRFAPPEPPEPWSGVRDATSQPAMCLQNLDILDEVGL-LDMKMILSSISM 121

  Fly    96 SEDCLFLNVYAPKVKSTRTPLPVMVWIHGGGFFFGNGNSDFHFPAKLM--EQEVIVVTLNYRLGA 158
            |||||:||||||......:.||||||||||....|..:.   :...|:  .::::|||:.||||.
  Rat   122 SEDCLYLNVYAPAHAREGSNLPVMVWIHGGALVVGMASM---YDGSLLTVNEDLVVVTIQYRLGV 183

  Fly   159 LGFLSLPEEGIHGNMGLKDQRLALEWVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRL 223
            |||.|..:|...||.|..||..||.|||:|||.|.|:||.||:|||||||:||..|..:..::.|
  Rat   184 LGFFSTGDEHARGNWGYLDQVAALRWVQQNIAHFGGNPNRVTIFGESAGGTSVSSHVISPMSQGL 248

  Fly   224 FHKAIMQSGTANMEWVFQNEAPAKTRRLAELLGGGDFGGDSKALLTFLQSEKATPTAILANTLKV 288
            ||.|||:||.|.:..:....:...:..:|:|  .|....||:||:..|:::......::....|:
  Rat   249 FHGAIMESGVALLPDLISETSETVSTTVAKL--SGCEAMDSEALVRCLRAKSGAEILVINKVFKM 311

  Fly   289 LSPDERRRHLPFAFKPVVEDSSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAE---------G 344
            :              |.|.|.    .||.:...||:..:| ...:|.|:|.|:.|         |
  Rat   312 I--------------PAVVDG----EFLPRHPKELLASED-FHPVPSIIGVNTDEYCCTIPMVMG 357

  Fly   345 LAIVVK--AKQKLEAYEDDLARLVPRNLVLDPQAPEAQEAASDIRAFFFNGQALSKENMDNLVD- 406
            .|.::|  :::.|:|...|.|    ..::|.|:.                |..|.:|.|.|..|
  Rat   358 TAQIIKELSRENLQAVLKDTA----AQMMLPPEC----------------GDLLMEEYMGNTDDS 402

  Fly   407 ---------LFSDYHFSMDLQRAVEIHASCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLRGVAHA 462
                     :..|:.|.:.   |:::....::.:|:|||...:...   |.|..:...:: ..||
  Rat   403 QTLQIQYTEMMGDFLFVIP---ALQVAHFQRSHAPVYFYEFQHAPS---YFKNVRPPHVK-ADHA 460

  Fly   463 DDICYLFQ--MAGDETEMNRDDLMVTERLCEMWANFARDGKPS----PIWKPVKKPHNGEPIQLD 521
            |::.::|.  .:|.:.:...::.:::.|:.:.||||||.|.|:    |.|..:  .|:.:.:|||
  Rat   461 DEVPFVFGSFFSGMKLDFTEEERLLSRRMMKYWANFARQGNPNSEGLPYWPAL--DHDEQYLQLD 523

  Fly   522 C-LLIDRELKMCSNPDGERMDFW 543
            . ..:||.||      ..|:.||
  Rat   524 THPAVDRALK------ARRLQFW 540

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	163/541 (30%)
Ces2	NP_001258232.1	COesterase	31..540	CDD:278561	163/541 (30%)
Ces2	NP_001258232.1	Aes	<130..>233	CDD:223730	52/105 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900