DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment clt and nlgn4x

DIOPT Version :9

Sequence 1:	NP_536784.1	Gene:	clt / 117300	FlyBaseID:	FBgn0000326	Length:	562	Species:	Drosophila melanogaster
Sequence 2:	XP_017946613.1	Gene:	nlgn4x / 100329189	XenbaseID:	XB-GENE-6036018	Length:	833	Species:	Xenopus tropicalis

Alignment Length:	628	Identity:	189/628 - (30%)
Similarity:	268/628 - (42%)	Gaps:	166/628 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 RPCG----RLIFT-------------------RF----CSSMKVKVPVKQGVLVGRQKKL---VN 38
            ||.|    .||||                   ||    |.:....||...|.:.|.:..|   :.
Frog     3 RPNGLLWLPLIFTPVCVLVNSNLLLWIAALAVRFTIVDCQAQHPIVPTNYGKIRGTRTPLPIEIL 67

  Fly    39 GLEYNSFLGVPYAEPPVGELRFRSPRPLERFQ------------KQELD--------------CS 77
            | ....:||||||.||.||.||:.|.|...:.            .|.||              .:
Frog    68 G-PVEQYLGVPYASPPTGERRFQPPEPPSSWTGIKNATQFAPVCPQFLDERSLLNDMLPIWFTAN 131

  Fly    78 KEGNVSYQRDPFTLEVAGSEDCLFLNVYAP-----------------------KVKSTRTPLPVM 119
            .:..|||.:|.       :||||:||:|.|                       .:.......|||
Frog   132 LDTVVSYVQDQ-------NEDCLYLNIYVPTEDGATTKKQADDIANNDRGEDEDIHDPNNKKPVM 189

  Fly   120 VWIHGGGFFFGNGNS-DFHFPAKLMEQEVIVVTLNYRLGALGFLSLPEEGIHGNMGLKDQRLALE 183
            |:||||.:..|.||. |....|.  ...|||:|:|||||.|||||..::...||.||.||..||.
Frog   190 VYIHGGSYMEGTGNMIDGSILAS--HGNVIVITVNYRLGVLGFLSTGDQAAKGNYGLLDQIQALR 252

  Fly   184 WVQENIASFNGDPNNVTLFGESAGGSSVHLHTFARHAKRLFHKAIMQSGTANMEWVFQNEAPAK- 247
            |::|||.:|.|||..||:||..||.|.|.|.|.:.:::.||.|||:|||||...|.. |..|||
Frog   253 WIEENIGAFGGDPKRVTIFGSGAGASCVSLLTLSHYSEGLFQKAIIQSGTALSSWAV-NYQPAKY 316

  Fly   248 TRRLAELLGGGDFGGDSKALLTFLQ--------SEKATPTAILANTLKVLSPDERRRHLPFAFKP 304
            ||.||:.:|....  |:..|:..|:        .:..||...               |:  ||.|
Frog   317 TRILADKVGCDML--DTIDLVECLRDKNYKELIQQSITPATY---------------HI--AFGP 362

  Fly   305 VVEDSSSPDRFLEQDIMELMHKKDCLGSMPVIMGYNSAEGLAIV---VKAKQ--KLEAYEDDLAR 364
            |::....||     |...||.:.:.| :..:::|.|..|||..|   |..:.  .|..::..::.
Frog   363 VIDGDVIPD-----DPQILMEQGEFL-NYDIMLGVNQGEGLKFVDGMVDNEDGVSLSDFDFSVSN 421

  Fly   365 LVPRNLVLDPQAPEAQEAASDIRAFFFNGQALSKENMD----NLVDLFSDYHFSMDLQRAVEIHA 425
            .|. ||.   ..||.::...:...|.:...| .|||.:    .||.||:|:.:........::||
Frog   422 FVD-NLY---GYPEGKDTLRETIKFMYTDWA-DKENPETRRKTLVALFTDHQWVAPAVATADLHA 481

  Fly   426 SCQTQSPLYFYRLDYVGGRNLYKKIFQNEDLRGVAHADDICYLF--QMAGDETEM-----NRDDL 483
              :..||.|||.. |...::..|..:.:.     ||.|::.|:|  .|.| .||:     :::|:
Frog   482 --RYGSPTYFYAF-YHHCQSEMKPTWADS-----AHGDEVPYVFGIPMIG-PTELFNCNFSKNDV 537

  Fly   484 MVTERLCEMWANFARDGKPSPIWKPV--------KKPHNGEPI 518
            |::..:...|.|||:.|.|:   |||        .||:..|.:
Frog   538 MLSAVVMTYWTNFAKTGDPN---KPVPQDTKFIHTKPNRFEEV 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
clt	NP_536784.1	COesterase	22..543	CDD:278561	179/583 (31%)
nlgn4x	XP_017946613.1	COesterase	46..610	CDD:365897	179/585 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910