Protein Alignment AP2M1 and APM4

DIOPT Version :10

• Sequence 1: NP_001298127.1
• Gene: AP2M1 / 1173
• HGNCID: 564
• Length: 460
• Species: Homo sapiens
• Sequence 2: NP_014579.1
• Gene: APM4 / 854092
• SGDID: S000005423
• Length: 491
• Species: Saccharomyces cerevisiae
• Alignment Length: 526
• Identity: 163/526 - (30%)
• Similarity: 269/526 - (51%)
• Gaps: 103/526 - (19%)

Human     1 MIGGLFIYNHKGEVLISRVYRDDIGSRQAADSAVFSSSGPFPGEWLEANRRNAVDAFRVNVIHAR 65
            ||.|:.:|:.:||:::::.:::.:                         :|:..|.|||.||: .
Yeast     1 MISGVLVYSSRGELVLNKFFKNSL-------------------------KRSISDIFRVQVIN-N 39

Human    66 QQVRSPVTNIARTSFFHVKR---SNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKIS-EENI 126
            ..|||||..:..|:|.|::.   .|:||..:|:.|.|:|.::|||||:..||.||  ::. ||.:
Yeast    40 LDVRSPVLTLGSTTFHHIRSRHGDNLWLVTITRSNANSAAIWEFLYKLDAVMNAY--RLDREEAL 102

Human   127 KNNFVLIYELLDEIL-DFGYPQNSETGALKTFITQQGIK-------------------------- 164
            |..|::::|:||.:| ..|.|.::|   |.:.|.|..:|
Yeast   103 KEEFMIVHEMLDIMLGGNGIPIDTE---LNSVIAQMSVKPVRNMGGLLDSPDGNDVLSSSSSPTS 164

Human   165 -------SQHQTKEE-----QSQITSQV--TGQIGWRREGIKYRRNELFLDVLESVNLLMSPQGQ 215
                   .:..||..     |...||..  ..:|.||.:||.::::|:||.|.|.:|:|:|..|.
Yeast   165 SAGELHFPKFLTKRSSSFLGQGDSTSDFYDNNKITWRPKGIIHKKDEVFLYVNERINILVSRDGS 229

Human   216 VLSAHVSGRVVMKSYLSGMPECKFGMNDKIVI--EKQGKGTADETSKSGKQ-------------S 265
            :|.::|.|.:.:.::|||.|.|:||:||.:.:  |.:.|..|.:...||..             |
Yeast   230 ILKSYVDGTIDITTHLSGTPICRFGLNDSLGMQSEDEKKWLAQQQRHSGSDFGNKNFIPKAAAGS 294

Human   266 IAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREVGR-TKLEVK 329
            :.::||.||:||.|.||:....|.|:||||..|||:|....:|.|||:|.|:|....| .:::.:
Yeast   295 VLLEDCKFHECVSLDKFNRNHIIEFVPPDGSMELMKYHVRDNINLPFKVTPIVTHSTRDNEIDYR 359

Human   330 VVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGMKESQISAE 394
            :.:||.|...|.|:.:.:.||.|.:|...::....|..|:...|||::|:..:..|:.|:.:||
Yeast   360 ITLKSLFPGKLSAKDVVLHIPVPPSTVDCKISVSNGHCKFVPEENAMIWRFNKYNGLTENTLSA- 423

Human   395 IELLPTNDK-----KKWARPPISMNFEV-PFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIGRS 453
             ..:.|:|.     ::|.|||||:.||| .|:.|||.|||..:....   |.|..:||::||.::
Yeast   424 -VTVSTSDTTQLNLQQWTRPPISLEFEVMMFSNSGLVVRYFTISGKD---SKHRAVKWIKYISKA 484

Human   454 GIYETR 459
            |.||.|
Yeast   485 GSYEVR 490

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP2M1	NP_001298127.1	AP2_Mu_N	1..165	CDD:341440	52/201 (26%)
		AP-2_Mu2_Cterm	193..459	CDD:271159	100/287 (35%)
APM4	NP_014579.1	AP2_Mu_N	1..142	CDD:341440	52/171 (30%)
		AP-2_Mu2_Cterm	207..490	CDD:271159	100/287 (35%)