Protein Alignment AP2M1 and AP-2mu

DIOPT Version :10

• Sequence 1: NP_001298127.1
• Gene: AP2M1 / 1173
• HGNCID: 564
• Length: 460
• Species: Homo sapiens
• Sequence 2: NP_651049.3
• Gene: AP-2mu / 42642
• FlyBaseID: FBgn0263351
• Length: 437
• Species: Drosophila melanogaster
• Alignment Length: 464
• Identity: 381/464 - (82%)
• Similarity: 412/464 - (88%)
• Gaps: 31/464 - (6%)

Human     1 MIGGLFIYNHKGEVLISRVYRDDIGSRQAADSAVFSSSGPFPGEWLEANRRNAVDAFRVNVIHAR 65
            ||||||:||||||||||||||||||                         |||||||||||||||
  Fly     1 MIGGLFVYNHKGEVLISRVYRDDIG-------------------------RNAVDAFRVNVIHAR 40

Human    66 QQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNF 130
            |||||||||||||||||:||:|||||||||||||||||||||.|:.:||.:||||||||||||||
  Fly    41 QQVRSPVTNIARTSFFHIKRANIWLAAVTKQNVNAAMVFEFLLKIIEVMQSYFGKISEENIKNNF 105

Human   131 VLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQHQTKEEQSQITSQVTGQIGWRREGIKYRR 195
            ||||||||||||||||||:::|.||||||||||||  .|||||.|||||||||||||||||||||
  Fly   106 VLIYELLDEILDFGYPQNTDSGTLKTFITQQGIKS--ATKEEQMQITSQVTGQIGWRREGIKYRR 168

Human   196 NELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTAD---- 256
            |||||||||.||||||||||||||||:|:||||||||||||||||:|||||:|.:|:|.:.
  Fly   169 NELFLDVLEYVNLLMSPQGQVLSAHVAGKVVMKSYLSGMPECKFGINDKIVMESKGRGLSGNSEA 233

Human   257 ETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREV 321
            |||:|||..:.||||.|||||:||||::|.||||||||||||||||||||||.||||||||||||
  Fly   234 ETSRSGKPVVVIDDCQFHQCVKLSKFETEHSISFIPPDGEFELMRYRTTKDISLPFRVIPLVREV 298

Human   322 GRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGM 386
            ||||:|||||:|||||||||.|||||:|||||||||||:||:|||||||||||||||||||||||
  Fly   299 GRTKMEVKVVLKSNFKPSLLGQKIEVKIPTPLNTSGVQLICLKGKAKYKASENAIVWKIKRMAGM 363

Human   387 KESQISAEIELLPTNDKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRYIG 451
            ||:|:|||||||.|:.||||.||||||||||||||||.|||||||||||||||||||:|||||||
  Fly   364 KETQLSAEIELLETDTKKKWTRPPISMNFEVPFAPSGFKVRYLKVFEPKLNYSDHDVVKWVRYIG 428

Human   452 RSGIYETRC 460
            |||:|||||
  Fly   429 RSGLYETRC 437

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP2M1	NP_001298127.1	AP2_Mu_N	1..165	CDD:341440	125/163 (77%)
		AP-2_Mu2_Cterm	193..459	CDD:271159	228/269 (85%)
AP-2mu	NP_651049.3	AP2_Mu_N	1..140	CDD:341440	125/163 (77%)
		AP-2_Mu2_Cterm	166..436	CDD:271159	228/269 (85%)