Protein Alignment AP2M1 and apm4

DIOPT Version :10

• Sequence 1: NP_001298127.1
• Gene: AP2M1 / 1173
• HGNCID: 564
• Length: 460
• Species: Homo sapiens
• Sequence 2: NP_592921.1
• Gene: apm4 / 2541527
• PomBaseID: SPAC31A2.09C
• Length: 446
• Species: Schizosaccharomyces pombe
• Alignment Length: 474
• Identity: 177/474 - (37%)
• Similarity: 280/474 - (59%)
• Gaps: 44/474 - (9%)

Human     1 MIGGLFIYNHKGEVLISRVYRDDIGSRQAADSAVFSSSGPFPGEWLEANRRNAVDAFRVNVIHAR 65
            ||.||||:|.||:.||.:.:|.|:                         :::..:.|||.:: ..
pombe     1 MISGLFIFNLKGDTLICKTFRHDL-------------------------KKSVTEIFRVAIL-TN 39

Human    66 QQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNF 130
            ...|.|:.:|..:::.:.|..::::.|:||.|.|..:|.|||..:...:..||||::|..:|:|.
pombe    40 TDYRHPIVSIGSSTYIYTKHEDLYVVAITKGNPNVMIVLEFLESLIQDLTHYFGKLNENTVKDNV 104

Human   131 VLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQHQT----KEEQSQI----TSQVTGQIGWR 187
            ..|:|||||::|:|..|.:|..||...::...:|.:...    :...||:    :|::.|.:.||
pombe   105 SFIFELLDEMIDYGIIQTTEPDALARSVSITAVKKKGNALSLKRSHSSQLAHTTSSEIPGSVPWR 169

Human   188 REGIKYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIE-KQG 251
            |.|||||:|.:::|::|.:|||:|..|.||.:.|||.|.|::.|||||||:||:|||:..: ||.
pombe   170 RAGIKYRKNSIYIDIVERMNLLISSTGNVLRSDVSGVVKMRAMLSGMPECQFGLNDKLDFKLKQS 234

Human   252 KGTADETSKSGKQS-----IAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILP 311
            :..:...:.....|     :.::||.|||||||.:|::|..|:|||||||.|||.||:.::|.:|
pombe   235 ESKSKSNNSRNPSSVNGGFVILEDCQFHQCVRLPEFENEHRITFIPPDGEVELMSYRSHENINIP 299

Human   312 FRVIPLVREVGRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAI 376
            ||::|:|.::.:.|:..::.|:::: |..|:..:..|||.|.|.........:|||.|:.|||.|
pombe   300 FRIVPIVEQLSKQKIIYRISIRADY-PHKLSSSLNFRIPVPTNVVKANPRVNRGKAGYEPSENII 363

Human   377 VWKIKRMAGMKESQISAEIELLPTNDKKKWARPPISMNFEV-PFAPSGLKVRYLKVFEPKLNYSD 440
            .|||.|..|..|....||:||..|.:::.||:||||::|.: .|..|||.|:||:|.||  :.|.
pombe   364 NWKIPRFLGETELIFYAEVELSNTTNQQIWAKPPISLDFNILMFTSSGLHVQYLRVSEP--SNSK 426

Human   441 HDVIKWVRYIGRSGIYETR 459
            :..||||||..|:|..|.|
pombe   427 YKSIKWVRYSTRAGTCEIR 445

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP2M1	NP_001298127.1	AP2_Mu_N	1..165	CDD:341440	48/163 (29%)
		AP-2_Mu2_Cterm	193..459	CDD:271159	117/272 (43%)
apm4	NP_592921.1	AP2_Mu_N	1..139	CDD:341440	48/163 (29%)
		AP-2_Mu2_Cterm	175..445	CDD:271159	117/272 (43%)