Protein Alignment AP2M1 and dpy-23

DIOPT Version :10

• Sequence 1: NP_001298127.1
• Gene: AP2M1 / 1173
• HGNCID: 564
• Length: 460
• Species: Homo sapiens
• Sequence 2: NP_741770.1
• Gene: dpy-23 / 180713
• WormBaseID: WBGene00001082
• Length: 441
• Species: Caenorhabditis elegans
• Alignment Length: 466
• Identity: 357/466 - (76%)
• Similarity: 401/466 - (86%)
• Gaps: 31/466 - (6%)

Human     1 MIGGLFIYNHKGEVLISRVYRDDIGSRQAADSAVFSSSGPFPGEWLEANRRNAVDAFRVNVIHAR 65
            ||||||:|||||||||||:||||:                         .|||||||||||||||
 Worm     1 MIGGLFVYNHKGEVLISRIYRDDV-------------------------TRNAVDAFRVNVIHAR 40

Human    66 QQVRSPVTNIARTSFFHVKRSNIWLAAVTKQNVNAAMVFEFLYKMCDVMAAYFGKISEENIKNNF 130
            |||||||||:||||||||||.|:|:.|||:||||||||||||.:..|.|.:||||::|||:||||
 Worm    41 QQVRSPVTNMARTSFFHVKRGNVWICAVTRQNVNAAMVFEFLKRFADTMQSYFGKLNEENVKNNF 105

Human   131 VLIYELLDEILDFGYPQNSETGALKTFITQQGIKSQHQ----TKEEQSQITSQVTGQIGWRREGI 191
            ||||||||||||||||||::.|.|||||||||:::...    |||||||||||||||||||||||
 Worm   106 VLIYELLDEILDFGYPQNTDPGVLKTFITQQGVRTADAPVPVTKEEQSQITSQVTGQIGWRREGI 170

Human   192 KYRRNELFLDVLESVNLLMSPQGQVLSAHVSGRVVMKSYLSGMPECKFGMNDKIVIEKQGKGTAD 256
            |||||||||||:|.|||||:.|||||||||:|:|.||||||||||||||:||||.||.:.|..:|
 Worm   171 KYRRNELFLDVIEYVNLLMNQQGQVLSAHVAGKVAMKSYLSGMPECKFGINDKITIEGKSKPGSD 235

Human   257 ETSKSGKQSIAIDDCTFHQCVRLSKFDSERSISFIPPDGEFELMRYRTTKDIILPFRVIPLVREV 321
            :.:|:.:.::|||||.|||||:|:||::|.:|||||||||:|||||||||||.||||||||||||
 Worm   236 DPNKASRAAVAIDDCQFHQCVKLTKFETEHAISFIPPDGEYELMRYRTTKDIQLPFRVIPLVREV 300

Human   322 GRTKLEVKVVIKSNFKPSLLAQKIEVRIPTPLNTSGVQVICMKGKAKYKASENAIVWKIKRMAGM 386
            .|.|:|||||:||||||||||||:|||||||.||||||:|||||||||||.||||||||||||||
 Worm   301 SRNKMEVKVVVKSNFKPSLLAQKLEVRIPTPPNTSGVQLICMKGKAKYKAGENAIVWKIKRMAGM 365

Human   387 KESQISAEIELLPTN--DKKKWARPPISMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRY 449
            |||||||||:||.|.  :||||.|||:||||||||||||||||||||||||||||||||||||||
 Worm   366 KESQISAEIDLLSTGNVEKKKWNRPPVSMNFEVPFAPSGLKVRYLKVFEPKLNYSDHDVIKWVRY 430

Human   450 IGRSGIYETRC 460
            |||||:|||||
 Worm   431 IGRSGLYETRC 441

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
AP2M1	NP_001298127.1	AP2_Mu_N	1..165	CDD:341440	113/163 (69%)
		AP-2_Mu2_Cterm	193..459	CDD:271159	217/267 (81%)
dpy-23	NP_741770.1	AP2_Mu_N	1..140	CDD:341440	113/163 (69%)
		AP-2_Mu2_Cterm	172..440	CDD:271159	217/267 (81%)