DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dsp1 and Hmgb2

DIOPT Version :9

Sequence 1:	NP_001138203.1	Gene:	Dsp1 / 117294	FlyBaseID:	FBgn0278608	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001350372.1	Gene:	Hmgb2 / 97165	MGIID:	96157	Length:	210	Species:	Mus musculus

Alignment Length:	216	Identity:	101/216 - (46%)
Similarity:	142/216 - (65%)	Gaps:	16/216 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 KPRGRMTAYAYFVQTCREEHKKKHPDETVIFAEFSRKCAERWKTMVDKEKKRFHEMAEKDKQRYE 246
            ||||:|::||:|||||||||||||||.:|.|||||:||:||||||..|||.:|.::|:.||.||:
Mouse     8 KPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDLAKSDKARYD 72

  Fly   247 AEMQNYVPPKGAVVGRGKKRKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGR 311
            .||:|||||||.  .:|||    ||||||||..||||.||::.|.|:|..:|...:||.||:||.
Mouse    73 REMKNYVPPKGD--KKGKK----KDPNAPKRPPSAFFLFCSENRPKIKIEHPGLSIGDTAKKLGE 131

  Fly   312 KWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGK--IAMSAPSMQASMQAQAQKAALLAAAAQ 374
            .||:...:.||.||..|.:.|.:||:::..|:..||  .....|......:.:.:        .:
Mouse   132 MWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGKSEAGKKGPGRPTGSKKKNE--------PE 188

  Fly   375 QQHQQLEEQHDDDDGDGDDDE 395
            .:.::.||:.::||.:.::||
Mouse   189 DEEEEEEEEEEEDDEEEEEDE 209

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsp1	NP_001138203.1	HMG-box	182..252	CDD:294061	47/69 (68%)
Dsp1	NP_001138203.1	HMGB-UBF_HMG-box	275..339	CDD:238686	29/63 (46%)
Hmgb2	NP_001350372.1	HMG-box	7..78	CDD:320749	47/69 (68%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..102		22/36 (61%)
		HMG_box	95..162	CDD:278906	29/66 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..210		10/56 (18%)
		Required for chemotactic activity. /evidence=ECO:0000250\|UniProtKB:P26583	165..180		3/14 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5930
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37582
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3622
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000133
OrthoInspector	1	1.000	-	-		otm43054
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48112
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3288
SonicParanoid	1	1.000	-	-		X111
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.990