DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dsp1 and TFAM

DIOPT Version :9

Sequence 1:	NP_001138203.1	Gene:	Dsp1 / 117294	FlyBaseID:	FBgn0278608	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_003192.1	Gene:	TFAM / 7019	HGNCID:	11741	Length:	246	Species:	Homo sapiens

Alignment Length:	177	Identity:	38/177 - (21%)
Similarity:	77/177 - (43%)	Gaps:	23/177 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   183 PRGRMTAYAYFVQTCREEHKKKHPDETVIFAEFSRKCAERWKTMVDKEKKRFHEMAEKDKQRYEA 247
            |:..:::|..|.:......|.::||...  .|..|:.|:||:.:.|.:||.:.:....:.|.|:.
Human    50 PKKPVSSYLRFSKEQLPIFKAQNPDAKT--TELIRRIAQRWRELPDSKKKIYQDAYRAEWQVYKE 112

  Fly   248 EMQNY---VPPKGAVVGRGK-------------KRKQIKDPNAPKRSLSAFFWFCNDERNKVKAL 296
            |:..:   :.| ..::...|             |:|::.....|||..||:..:..:...:.|..
Human   113 EISRFKEQLTP-SQIMSLEKEIMDKHLKRKAMTKKKELTLLGKPKRPRSAYNVYVAERFQEAKGD 176

  Fly   297 NPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYK 343
            :|:    :..|.:...|.::....|:.|...|:.|:.||..||..::
Human   177 SPQ----EKLKTVKENWKNLSDSEKELYIQHAKEDETRYHNEMKSWE 219

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsp1	NP_001138203.1	HMG-box	182..252	CDD:294061	17/68 (25%)
Dsp1	NP_001138203.1	HMGB-UBF_HMG-box	275..339	CDD:238686	15/63 (24%)
TFAM	NP_003192.1	HMG_box	50..117	CDD:395407	17/68 (25%)
TFAM	NP_003192.1	HMGB-UBF_HMG-box	155..216	CDD:238686	16/64 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48112
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910