DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dsp1 and hmgb3a

DIOPT Version :9

Sequence 1:	NP_001138203.1	Gene:	Dsp1 / 117294	FlyBaseID:	FBgn0278608	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001116308.1	Gene:	hmgb3a / 561025	ZFINID:	ZDB-GENE-050428-1	Length:	213	Species:	Danio rerio

Alignment Length:	215	Identity:	96/215 - (44%)
Similarity:	138/215 - (64%)	Gaps:	10/215 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 KPRGRMTAYAYFVQTCREEHKKKHPDETVIFAEFSRKCAERWKTMVDKEKKRFHEMAEKDKQRYE 246
            ||:|:|:||||||||||||||||.|:..|.|:|||::|:.|||.|.||||.||.:||::||.||:
Zfish     8 KPKGKMSAYAYFVQTCREEHKKKSPEIPVSFSEFSKRCSGRWKAMTDKEKSRFEDMAKQDKVRYD 72

  Fly   247 AEMQNYVPPKGAVVGRGKKRKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGR 311
            .||.:|:|.|     ||||    ||||||||..|.||.||::.|.::||..|..|:||:||:||.
Zfish    73 QEMMHYMPGK-----RGKK----KDPNAPKRPPSGFFLFCSEHRPQIKAQYPSLGIGDVAKKLGE 128

  Fly   312 KWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIAMSAPSMQASM-QAQAQKAALLAAAAQQ 375
            .|:.:....||.:...|.:.|.:|::::.:|||..|....:..|...| .....|..:.:....:
Zfish   129 MWNGLTDANKQPFLMKANKLKDKYQKDVADYKTKSKAGGVSMGMGMPMANCMPPKPMMKSNMDDE 193

  Fly   376 QHQQLEEQHDDDDGDGDDDE 395
            :..:.:|:.::||.:.||||
Zfish   194 EDDEEDEEEEEDDDEYDDDE 213

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsp1	NP_001138203.1	HMG-box	182..252	CDD:294061	45/69 (65%)
Dsp1	NP_001138203.1	HMGB-UBF_HMG-box	275..339	CDD:238686	25/63 (40%)
hmgb3a	NP_001116308.1	HMG_box_2	7..78	CDD:286146	45/69 (65%)
hmgb3a	NP_001116308.1	HMG_box	92..159	CDD:278906	25/66 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583917
Domainoid	1	1.000	117	1.000	Domainoid score	I5857
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3548
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000133
OrthoInspector	1	1.000	-	-		otm24274
orthoMCL	1	0.900	-	-		OOG6_100324
Panther	1	1.100	-	-	O	PTHR48112
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X111
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	13	12.750