DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dsp1 and hmgb3b

DIOPT Version :9

Sequence 1:	NP_001138203.1	Gene:	Dsp1 / 117294	FlyBaseID:	FBgn0278608	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001017769.1	Gene:	hmgb3b / 550466	ZFINID:	ZDB-GENE-050417-290	Length:	198	Species:	Danio rerio

Alignment Length:	218	Identity:	100/218 - (45%)
Similarity:	136/218 - (62%)	Gaps:	23/218 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   178 KAD-AKPRGRMTAYAYFVQTCREEHKKKHPDETVIFAEFSRKCAERWKTMVDKEKKRFHEMAEKD 241
            |.| .||:|:|:||||||:||||||.||:|..||.|:|||:||:||||||..|||.:|.::|::|
Zfish     3 KGDPGKPKGKMSAYAYFVKTCREEHNKKNPGVTVNFSEFSKKCSERWKTMSPKEKTKFEDLAKQD 67

  Fly   242 KQRYEAEMQNYVPPKGAVVGRGKKRKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIA 306
            |.||:.||.:|.|.|       |.|||.||||||:|..|.||.||.::|..:||.||..|:||:|
Zfish    68 KARYDQEMMHYNPGK-------KGRKQKKDPNAPRRPPSGFFLFCAEQRPIIKAQNPSLGIGDVA 125

  Fly   307 KELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIAMSAPSMQASMQAQAQKAALLAA 371
            |:||..|:::....||.:.|.|::.|.:|:::|..|:..|    |..|..|..:.:
Zfish   126 KKLGGMWNNLSDSEKQPFLSNADKLKDKYQKDMAFYRKKG----SGGSSSAKSEPK--------- 177

  Fly   372 AAQQQHQQLEEQHDDDDGDGDDD 394
              .......||:.||||.|.|||
Zfish   178 --DDDDDDDEEEEDDDDDDEDDD 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsp1	NP_001138203.1	HMG-box	182..252	CDD:294061	44/69 (64%)
Dsp1	NP_001138203.1	HMGB-UBF_HMG-box	275..339	CDD:238686	26/63 (41%)
hmgb3b	NP_001017769.1	HMG_box_2	7..78	CDD:286146	44/70 (63%)
hmgb3b	NP_001017769.1	HMG_box	94..161	CDD:278906	27/66 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170583916
Domainoid	1	1.000	117	1.000	Domainoid score	I5857
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	219	1.000	Inparanoid score	I3548
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000133
OrthoInspector	1	1.000	-	-		otm24274
orthoMCL	1	0.900	-	-		OOG6_100324
Panther	1	1.100	-	-	O	PTHR48112
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X111
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	12	11.750