DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dsp1 and HMGB2

DIOPT Version :9

Sequence 1:	NP_001138203.1	Gene:	Dsp1 / 117294	FlyBaseID:	FBgn0278608	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001124160.1	Gene:	HMGB2 / 3148	HGNCID:	5000	Length:	209	Species:	Homo sapiens

Alignment Length:	214	Identity:	103/214 - (48%)
Similarity:	142/214 - (66%)	Gaps:	13/214 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 KPRGRMTAYAYFVQTCREEHKKKHPDETVIFAEFSRKCAERWKTMVDKEKKRFHEMAEKDKQRYE 246
            ||||:|::||:|||||||||||||||.:|.|||||:||:||||||..|||.:|.:||:.||.||:
Human     8 KPRGKMSSYAFFVQTCREEHKKKHPDSSVNFAEFSKKCSERWKTMSAKEKSKFEDMAKSDKARYD 72

  Fly   247 AEMQNYVPPKGAVVGRGKKRKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGR 311
            .||:|||||||.  .:|||    ||||||||..||||.||::.|.|:|:.:|...:||.||:||.
Human    73 REMKNYVPPKGD--KKGKK----KDPNAPKRPPSAFFLFCSEHRPKIKSEHPGLSIGDTAKKLGE 131

  Fly   312 KWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIAMSAPSMQASMQAQAQKAALLAAAAQQQ 376
            .||:...:.||.||..|.:.|.:||:::..|:..||       .:|..:...:..........:.
Human   132 MWSEQSAKDKQPYEQKAAKLKEKYEKDIAAYRAKGK-------SEAGKKGPGRPTGSKKKNEPED 189

  Fly   377 HQQLEEQHDDDDGDGDDDE 395
            .::.||:.|:|:.:.|:||
Human   190 EEEEEEEEDEDEEEEDEDE 208

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsp1	NP_001138203.1	HMG-box	182..252	CDD:294061	48/69 (70%)
Dsp1	NP_001138203.1	HMGB-UBF_HMG-box	275..339	CDD:238686	29/63 (46%)
HMGB2	NP_001124160.1	HMG_box_2	6..78	CDD:401091	48/69 (70%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	52..150		54/103 (52%)
		HMG_box	95..162	CDD:395407	29/66 (44%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..209		11/54 (20%)
		Required for chemotactic activity. /evidence=ECO:0000269\|PubMed:19811285	165..180		3/21 (14%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	117	1.000	Domainoid score	I5909
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H37582
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3638
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000133
OrthoInspector	1	1.000	-	-		otm40983
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48112
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3288
SonicParanoid	1	1.000	-	-		X111
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	11	10.990