DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dsp1 and TOX3

DIOPT Version :9

Sequence 1:	NP_001138203.1	Gene:	Dsp1 / 117294	FlyBaseID:	FBgn0278608	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001073899.2	Gene:	TOX3 / 27324	HGNCID:	11972	Length:	576	Species:	Homo sapiens

Alignment Length:	364	Identity:	70/364 - (19%)
Similarity:	118/364 - (32%)	Gaps:	118/364 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    29 QVQQQQLQQHQVVVQQN--QQQAHQNSSNTTAGVGTQQLFTYKMASSFPNPATTMAQVVATSNAA 91
            |...|.|....:.:.:|  :|....:||.........|:..|:.     :|:..|..:|
Human   105 QFPPQSLDLPSITISRNLVEQDGVLHSSGLHMDQSHTQVSQYRQ-----DPSLIMRSIV------ 158

  Fly    92 GTTGYDYRLNMAQAAAAAAVPGSQWWYSAANQGQVDANT-----AAQLQHQQQQQQQQQQQQQQQ 151
                     :|..||.:..:|.:|  .:..||.|:.|..     .|.:.|
Human   159 ---------HMTDAARSGVMPPAQ--LTTINQSQLSAQLGLNLGGASMPH--------------- 197

  Fly   152 HQQQQQMQQQQQQQNVINSASPMSRVKADAKPRGRMTAYAYFVQTCREEHKKKHPDETVIFAEFS 216
                             .|.||.:...|...|...:              .::..||.      :
Human   198 -----------------TSPSPPASKSATPSPSSSI--------------NEEDADEA------N 225

  Fly   217 RKCAERWKTMVDKEKKRFHEMAEKDKQRYEAEMQNYVPPKGAVVGRGKKRKQIKDPNAPKRSLSA 281
            |...|: :...|..||                      ||      ..|:|:.||||.|::.:||
Human   226 RAIGEK-RAAPDSGKK----------------------PK------TPKKKKKKDPNEPQKPVSA 261

  Fly   282 FFWFCNDERNKVKALNPEFGVGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEYKTS- 345
            :..|..|.:..:|..||....|:::|.:...|..:..|.||.|:...|..|..|.:.:..|:.|
Human   262 YALFFRDTQAAIKGQNPNATFGEVSKIVASMWDSLGEEQKQVYKRKTEAAKKEYLKALAAYRASL 326

  Fly   346 -------GKIAMSAPSMQASMQAQAQKAALLAAAAQQQH 377
                   ...|.:..|:|.::.:....::||......||
Human   327 VSKAAAESAEAQTIRSVQQTLASTNLTSSLLLNTPLSQH 365

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsp1	NP_001138203.1	HMG-box	182..252	CDD:294061	8/69 (12%)
Dsp1	NP_001138203.1	HMGB-UBF_HMG-box	275..339	CDD:238686	18/63 (29%)
TOX3	NP_001073899.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	189..258		23/149 (15%)
		HMG-box	255..320	CDD:238037	18/64 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	422..443
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	519..563
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810