DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dsp1 and Hmgb1

DIOPT Version :9

Sequence 1:	NP_001138203.1	Gene:	Dsp1 / 117294	FlyBaseID:	FBgn0278608	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001300823.1	Gene:	Hmgb1 / 15289	MGIID:	96113	Length:	215	Species:	Mus musculus

Alignment Length:	214	Identity:	99/214 - (46%)
Similarity:	146/214 - (68%)	Gaps:	6/214 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 KPRGRMTAYAYFVQTCREEHKKKHPDETVIFAEFSRKCAERWKTMVDKEKKRFHEMAEKDKQRYE 246
            ||||:|::||:|||||||||||||||.:|.|:|||:||:||||||..|||.:|.:||:.||.|||
Mouse     8 KPRGKMSSYAFFVQTCREEHKKKHPDASVNFSEFSKKCSERWKTMSAKEKGKFEDMAKADKARYE 72

  Fly   247 AEMQNYVPPKGAVVGRGKKRKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGR 311
            .||:.|:|||      |:.:|:.||||||||..||||.||::.|.|:|..:|...:||:||:||.
Mouse    73 REMKTYIPPK------GETKKKFKDPNAPKRPPSAFFLFCSEYRPKIKGEHPGLSIGDVAKKLGE 131

  Fly   312 KWSDVDPEVKQKYESMAERDKARYEREMTEYKTSGKIAMSAPSMQASMQAQAQKAALLAAAAQQQ 376
            .|::...:.||.||..|.:.|.:||:::..|:..||...:...:..:.:::.:|........::.
Mouse   132 MWNNTAADDKQPYEKKAAKLKEKYEKDIAAYRAKGKPDAAKKGVVKAEKSKKKKEEEDDEEDEED 196

  Fly   377 HQQLEEQHDDDDGDGDDDE 395
            .::.||:.|:|:.:.||||
Mouse   197 EEEEEEEEDEDEEEDDDDE 215

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsp1	NP_001138203.1	HMG-box	182..252	CDD:294061	48/69 (70%)
Dsp1	NP_001138203.1	HMGB-UBF_HMG-box	275..339	CDD:238686	28/63 (44%)
Hmgb1	NP_001300823.1	Sufficient for interaction with HAVCR2. /evidence=ECO:0000269\|PubMed:22842346	1..97		60/94 (64%)
		Heparin-binding. /evidence=ECO:0000250\|UniProtKB:P10103	1..10		1/1 (100%)
		LPS binding (delipidated). /evidence=ECO:0000250\|UniProtKB:P09429	3..15		5/6 (83%)
		HMG_box_2	6..78	CDD:401091	48/69 (70%)
		NLS 1. /evidence=ECO:0000250\|UniProtKB:P63159	27..43		11/15 (73%)
		Nuclear localization signal (NLS) 1. /evidence=ECO:0000250\|UniProtKB:P63159	27..43		11/15 (73%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	76..95		10/24 (42%)
		LPS binding (Lipid A). /evidence=ECO:0000250\|UniProtKB:P09429	80..96		10/21 (48%)
		Cytokine-stimulating activity. /evidence=ECO:0000250\|UniProtKB:P09429	89..108		14/18 (78%)
		HMG_box	95..162	CDD:395407	28/66 (42%)
		Binding to AGER/RAGE. /evidence=ECO:0000250\|UniProtKB:P63159	150..183		6/32 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	161..215		10/53 (19%)
		NLS 2. /evidence=ECO:0000250\|UniProtKB:P63159	178..184		0/5 (0%)
		Nuclear localization signal (NLS) 2. /evidence=ECO:0000250\|UniProtKB:P63159	178..184		0/5 (0%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	116	1.000	Domainoid score	I5930
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	213	1.000	Inparanoid score	I3622
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000133
OrthoInspector	1	1.000	-	-		otm43054
orthoMCL	1	0.900	-	-		OOG6_100324
Panther	1	1.100	-	-	LDO	PTHR48112
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3288
SonicParanoid	1	1.000	-	-		X111
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.890