DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dsp1 and HMGB4

DIOPT Version :9

Sequence 1:	NP_001138203.1	Gene:	Dsp1 / 117294	FlyBaseID:	FBgn0278608	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001366230.1	Gene:	HMGB4 / 127540	HGNCID:	24954	Length:	186	Species:	Homo sapiens

Alignment Length:	175	Identity:	62/175 - (35%)
Similarity:	97/175 - (55%)	Gaps:	12/175 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   182 KPRGRMTAYAYFVQTCREEHKKKHPDETVIFAEFSRKCAERWKTMVDKEKKRFHEMAEKDKQRYE 246
            ||:..:::|.:|:...|.:.|::.|:..|.|.||||||:|:|:::...||.::..:|:.||.||:
Human     8 KPKANVSSYVHFLLNYRNKFKEQQPNTYVGFKEFSRKCSEKWRSISKHEKAKYEALAKLDKARYQ 72

  Fly   247 AEMQNYVPPKGAVVGRGKKRKQIKDPNAPKRSLSAFFWFCNDERNKVKALNPEFGVGDIAKELGR 311
            .||.||       ||:.|||:: :||..|:|..|:|..||.|...::|..||.:.|..:||..|:
Human    73 EEMMNY-------VGKRKKRRK-RDPQEPRRPPSSFLLFCQDHYAQLKRENPNWSVVQVAKATGK 129

  Fly   312 KWSDVDPEVKQKYESMAERDKARYEREMTEYK----TSGKIAMSA 352
            .||......|..||......:|:|..|:..|:    ...|..|||
Human   130 MWSTATDLEKHPYEQRVALLRAKYFEELELYRKQCNARKKYRMSA 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsp1	NP_001138203.1	HMG-box	182..252	CDD:294061	26/69 (38%)
Dsp1	NP_001138203.1	HMGB-UBF_HMG-box	275..339	CDD:238686	21/63 (33%)
HMGB4	NP_001366230.1	HMG-box	8..78	CDD:412149	26/69 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	77..98		11/28 (39%)
		HMG-box	93..158	CDD:238037	22/64 (34%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000133
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR48112
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X111
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.970