DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dsp1 and HMG20A

DIOPT Version :9

Sequence 1:	NP_001138203.1	Gene:	Dsp1 / 117294	FlyBaseID:	FBgn0278608	Length:	397	Species:	Drosophila melanogaster
Sequence 2:	NP_001291433.1	Gene:	HMG20A / 10363	HGNCID:	5001	Length:	347	Species:	Homo sapiens

Alignment Length:	147	Identity:	51/147 - (34%)
Similarity:	80/147 - (54%)	Gaps:	10/147 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   238 AEKDKQRYEAEMQNYVPPKGAVVGRGKKRKQ-IKDPNAPKRSLSAFFWFCNDERNKVKALNPEFG 301
            ||.::||:|.|.::    |.....:|:|||: ::|.||||..|:.:..|.|:.|.:::|..||..
Human    69 AEGNEQRHEDEQRS----KRGGWSKGRKRKKPLRDSNAPKSPLTGYVRFMNERREQLRAKRPEVP 129

  Fly   302 VGDIAKELGRKWSDVDPEVKQKYESMAERDKARYEREMTEY-KTSGKIAMSAPSMQASMQAQAQK 365
            ..:|.:.||.:||.:.||.||:|...|:|||.||.:|:.:| ||......|    :.:...|..|
Human   130 FPEITRMLGNEWSKLPPEEKQRYLDEADRDKERYMKELEQYQKTEAYKVFS----RKTQDRQKGK 190

  Fly   366 AALLAAAAQQQHQQLEE 382
            :....||.|..|...:|
Human   191 SHRQDAARQATHDHEKE 207

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dsp1	NP_001138203.1	HMG-box	182..252	CDD:294061	6/13 (46%)
Dsp1	NP_001138203.1	HMGB-UBF_HMG-box	275..339	CDD:238686	25/63 (40%)
HMG20A	NP_001291433.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..113		17/47 (36%)
		DUF5401	<59..313	CDD:375164	51/147 (35%)
		HMGB-UBF_HMG-box	103..168	CDD:238686	26/64 (41%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	179..211		8/33 (24%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5648
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3288
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.840