DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Rps6ka2 and S6k

DIOPT Version :9

Sequence 1:	XP_038934903.1	Gene:	Rps6ka2 / 117269	RGDID:	620676	Length:	762	Species:	Rattus norvegicus
Sequence 2:	NP_001261450.1	Gene:	S6k / 38654	FlyBaseID:	FBgn0283472	Length:	490	Species:	Drosophila melanogaster

Alignment Length:	407	Identity:	188/407 - (46%)
Similarity:	263/407 - (64%)	Gaps:	34/407 - (8%)

- Green bases have known domain annotations that are detailed below.

  Rat    12 KIEVEPMEIETTEEELSLDIEPTPEDTTEEGKGDTTASAETQPASSSSSAEEEGIVKEIDISSHV 76
            :||::.:::   |.||.:::.   :||  ||: :|....|                      .:|
  Fly    32 RIELDDVDL---EPELCINLH---QDT--EGQ-ETIQLCE----------------------ENV 65

  Rat    77 KEGFEKADPSQFELLKVLGQGSYGKVFLVRKVTGSDAGQLYAMKVLKKATL--KVRDRVRSKMER 139
            ..|..|..|..|||.||||:|.|||||.|||..|.||.:.:||||||||::  ..:|...::.||
  Fly    66 NPGKIKLGPKDFELKKVLGKGGYGKVFQVRKTAGRDANKYFAMKVLKKASIVTNQKDTAHTRAER 130

  Rat   140 DILAEVNHPFIVKLHYAFQTEGKLYLILDFLRGGDLFTRLSKEVMFTEEDVKFYLAELALALDHL 204
            :||..|.|||||:|.|||||:|||||||::|.||:||..|.:|.:|.|:...|||:|:.|||.||
  Fly   131 NILEAVKHPFIVELVYAFQTDGKLYLILEYLSGGELFMHLEREGIFLEDTTCFYLSEIILALGHL 195

  Rat   205 HGLGIIYRDLKPENILLDEEGHIKITDFGLSKEAIDHDKRAYSFCGTIEYMAPEVVNRRGHTQSA 269
            |.||||||||||||||||.:||:|:|||||.||.|......::|||||||||||::.|.||.::.
  Fly   196 HKLGIIYRDLKPENILLDAQGHVKLTDFGLCKEHIQEGIVTHTFCGTIEYMAPEILTRSGHGKAV 260

  Rat   270 DWWSFGVLMFEMLTGSLPFQGKDRKETMALILKAKLGMPQFLSAEAQSLLRALFKRNPCNRLGAG 334
            ||||.|.|||:||||..||..::||:|:..||||||.:|.:|:.||:.|:|.|.||....|||:|
  Fly   261 DWWSLGALMFDMLTGVPPFTAENRKKTIETILKAKLNLPAYLTPEARDLVRRLMKRQEPQRLGSG 325

  Rat   335 VDGVEEIKRHPFFVTIDWNKLYRKEIKPPFKPAVGRPEDTFHFDPEFTARTPTDSP-GVPPSANA 398
            .:....::.||||..::|:.:..:.::||.||.:...:|...||..||.:.|.||| ....|.:|
  Fly   326 PEDAAAVQIHPFFKHVNWDDVLARRLEPPIKPLLRSEDDVSQFDTRFTRQIPVDSPDDTTLSESA 390

  Rat   399 HHLFRGFSFVASSLVQE 415
            :.:|:||::||.|::::
  Fly   391 NLIFQGFTYVAPSILED 407

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Rps6ka2	XP_038934903.1	STKc_RSK_N	92..408	CDD:270734	167/318 (53%)
Rps6ka2	XP_038934903.1	STKc_RSK3_C	440..732	CDD:271080
S6k	NP_001261450.1	PTZ00263	76..397	CDD:140289	168/320 (53%)
S6k	NP_001261450.1	STKc_p70S6K	81..402	CDD:270736	168/320 (53%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166334264
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1132245at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.850