DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pex6 and Pex6

DIOPT Version :9

Sequence 1:	NP_476466.1	Gene:	Pex6 / 117265	RGDID:	621637	Length:	978	Species:	Rattus norvegicus
Sequence 2:	NP_001027403.2	Gene:	Pex6 / 3772165	FlyBaseID:	FBgn0033564	Length:	899	Species:	Drosophila melanogaster

Alignment Length:	820	Identity:	269/820 - (32%)
Similarity:	422/820 - (51%)	Gaps:	160/820 - (19%)

- Green bases have known domain annotations that are detailed below.

  Rat   237 PHLAQVQVLEPRWDLSARLGPNSGQPGEPLADGLVFVPATLAFNLGCDPLEVGE---LRIQRYLE 298
            ||....|:|.     :|:..||           .::|......|: .|..::..   ::::.:.:
  Fly   159 PHTIVAQILP-----AAQCQPN-----------CLYVQENFYGNI-LDRFQIRSNCWVQVEHFAD 206

  Rat   299 DSTAAEDKGSCSLLPGPPFARELHIEVLPSPHCGVNGKYDHVLYQHFHTPRVVQEG--------- 354
            :.|          :||  .|.:.|:.::..||.......:.:|..:|:|||::..|
  Fly   207 EQT----------IPG--IATKAHVYLVADPHELPAELTEVILSNYFNTPRLMHRGHTYRIEVNA 259

  Rat   355 DVLCVSTAGQVEILEGSLERLPRWREVFFK----------------VKKTVGEAPDGPAS-AFLA 402
            :::..:|.....::...|      |.|..|                |.|........||| :||.
  Fly   260 ELVGTATYAHYYLIFAHL------RHVHLKCIHLETKGSEFELQAIVAKNFSNLVQVPASHSFLP 318

  Rat   403 DTTHTSLYLAGTTLSRVPPLPSGRSPPWDSLSPPGLEALVNELCAVL-KPHLQPGGTLLTGTSCV 466
            .....|:.:       |...|||...|: .|....::|.:.:..|.| ..|:.|         ..
  Fly   319 RQVLDSMAI-------VENYPSGLRKPY-KLLRSSVDAFLPKKSACLSSKHIFP---------VF 366

  Rat   467 LLQGPPGSGKTTAVTAACSRLGLHLLKVPCSSLCADSSRTVETKLQTTFSRARRCRPVVLLLTAL 531
            ||||..||||:..|:|....||:|:....|:.:.:......|.||:..|::::.|.|:::.....
  Fly   367 LLQGERGSGKSKLVSAVAQELGMHIYGADCAEIVSQVPSHTEMKLKAVFAKSQVCEPLMICFHNF 431

  Rat   532 DLLGRDRDGLGEDARVVATLRHL----LLDEDPLSRCPPLMVVATTSRVQDLPTDVRTAFPHELE 592
            ::.|.|.:| .||.|:::.. |:    |.:.|   |..|::|||.||. :.|...::..|...:.
  Fly   432 EIFGIDNEG-NEDLRLLSAF-HVQVQELFNRD---RKHPIVVVALTSD-RHLKPMIQGLFLEIIN 490

  Rat   593 VPVLSESQRLSVL---------------QALTAHLPLGQEVNLSQ------------------LA 624
            :.:.|:.:|..:|               |.....|||....|.||                  :|
  Fly   491 IDMPSKEERFEILRWMHVRETFNDIIYNQKAIEQLPLFSRENQSQFMPRISPSWRETLNVLQDVA 555

  Rat   625 RRCAGFVVGDLYALLTHASRAAC-TRIKAAGLAMSEEDEGELCAAGFPLLAEDFGQALDQLQTAH 688
            .:..||::|||..|..:|.|... .|:....|.||.                 |.:.|..:|::.
  Fly   556 AKSQGFLLGDLQLLYDNAVRMKIRNRLGRTTLDMSH-----------------FAKNLTDMQSSF 603

  Rat   689 SQAVGAPKIPSVSWHDVGGLQDVKKEILETIQLPLEHPELLSLGLRRSGLLLHGPPGTGKTLLAK 753
            :.::||||:|.|.|.|:|||..:|.||..:|.|||:|..|:...|||||:||:|||||||||:||
  Fly   604 ADSLGAPKVPKVYWSDIGGLAKLKDEIQSSIGLPLKHVHLMGKNLRRSGILLYGPPGTGKTLVAK 668

  Rat   754 AVATECSLTFLSVKGPELINMYVGQSEENVREVFARARAAAPCIIFFDELDSLAPSRGRSGDSGG 818
            ||||||:|:||||:||||:||||||||:||||||:|||:||||::|.||||||||:||.:|||||
  Fly   669 AVATECNLSFLSVQGPELLNMYVGQSEQNVREVFSRARSAAPCVLFLDELDSLAPNRGVAGDSGG 733

  Rat   819 VMDRVVSQLLAELDGL---HSTQDVFVIGATNRPDLLDPALLRPGRFDKLVFVG---ASEDRASQ 877
            ||||||||||||:||:   .:::.:|::.|||||||:|||||||||||||.:||   .:||:|:
  Fly   734 VMDRVVSQLLAEMDGMSDGDTSKPIFILAATNRPDLIDPALLRPGRFDKLFYVGPCSTAEDKAA- 797

  Rat   878 LRVLSAITRKFKLEASVSLMNVLDCCPPQLTGADLYSLCSDAMMTALKRRVRD------LEEGLE 936
              ||.|.|::|.|:|.|.:..:.:....:::||||||:||:|.::|::|.:..      .|:.|.
  Fly   798 --VLRAQTQRFALDAGVDMEQIAERLKSEMSGADLYSICSNAWLSAVRRTIDGHLSGTISEKELV 860

  Rat   937 PRSSALLLTMEDLLQAAARLQPSVSEQELLRYKRIQRKFA 976
            |.:  :::..||..::..:..||:|.::|..:..::..::
  Fly   861 PEN--VIVQEEDFTKSFNKFVPSISAKDLEYFNNLKASYS 898

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pex6	NP_476466.1	SpoVK	463..965	CDD:223540	221/551 (40%)
		AAA	466..595	CDD:278434	38/132 (29%)
		AAA	741..869	CDD:278434	98/130 (75%)
		Vps4_C	923..975	CDD:286426	11/57 (19%)
Pex6	NP_001027403.2	SpoVK	367..847	CDD:223540	216/524 (41%)
		P-loop_NTPase	367..492	CDD:304359	35/129 (27%)
		AAA	653..787	CDD:278434	103/136 (76%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166350802
Domainoid	1	1.000	213	1.000	Domainoid score	I2672
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	374	1.000	Inparanoid score	I2035
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D233419at2759
OrthoFinder	1	1.000	-	-		FOG0004626
OrthoInspector	1	1.000	-	-		oto96970
orthoMCL	1	0.900	-	-		OOG6_103617
Panther	1	1.100	-	-	LDO	PTHR23077
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3235
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.900