DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CATSPER2 and CCH1

DIOPT Version :9

Sequence 1:	NP_001269239.1	Gene:	CATSPER2 / 117155	HGNCID:	18810	Length:	534	Species:	Homo sapiens
Sequence 2:	NP_011733.3	Gene:	CCH1 / 853131	SGDID:	S000003449	Length:	2039	Species:	Saccharomyces cerevisiae

Alignment Length:	343	Identity:	78/343 - (22%)
Similarity:	151/343 - (44%)	Gaps:	47/343 - (13%)

- Green bases have known domain annotations that are detailed below.

Human   119 FIIFLVFLNTIILMVEIELLESTNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAW 183
            ||..::.:..|.:...:::..|.|.....||....::  .:|.|..|..|:.:|.|...|.....
Yeast   774 FIFVILIICDIGMRASVKVSTSANCNNILLKTDRGIS--IVLFIESLARLVLYLPNMWKFLTKPS 836

Human   184 NVFDFVVTMLSLLPEVVVLVGVTGQS-VWLQLLRICRVLRSL-------KLLAQFRQIQIIILVL 240
            .|:||::::::|:...:.:.||.|.. .||.:..|.|..|.:       ||..|.....::|..|
Yeast   837 YVYDFIISIITLVISCLAVEGVLGHMYAWLSIFHISRFYRVIISFNLTKKLWKQILSNGVMIWNL 901

Human   241 VRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHVF-FSDLPNSLVTVFILFTLDH 304
            .......|||:.:::..::    .||.        |.:::....| ...||||.:::||:.:.::
Yeast   902 SSFYFFFTFLVAIIMAVYF----EGVI--------PPEEMADQPFGMYSLPNSFLSLFIIGSTEN 954

Human   305 WYALLQDVWK-VPEV-SRIFSSIYFILWLLLGSIIFRSIIVAMMVTNFQNIRKELNEEMARREVQ 367
            |..:|..:.| .|.: |..|.|::||:|.||.:.:..:|.:|::..:.     |:.|| .:|..|
Yeast   955 WTDILYALQKHSPNISSTFFCSVFFIIWFLLSNSVILNIFIALISESM-----EVKEE-EKRPQQ 1013

Human   368 LKADMFKRQIIQRRKNMSHEALTSSHSKIEDR--GASQQRESLDLSE-------VSEVESNYGAT 423
            :| ...|....|:.:..:|.:|.   ::|..:  |..:..::.|..:       :..:..|.|..
Yeast  1014 IK-HYLKFVYPQKIQEYTHASLV---ARIRKKFFGGHRNEDTRDFKQFLMRGTAIMNIAQNMGEL 1074

Human   424 EEDLITSASKTEETLSKK 441
            .::.....|   |.|.||
Yeast  1075 ADEFKEPPS---ENLFKK 1089

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CATSPER2	NP_001269239.1	Ion_trans	178..356	CDD:278921	45/188 (24%)
CCH1	NP_011733.3	Ion_trans	<483..722	CDD:395416
		Ion_trans	769..1010	CDD:395416	61/255 (24%)
		Ion_trans	1210..1480	CDD:395416
		Ion_trans	1529..1776	CDD:395416
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	67	1.000	Domainoid score	I2620
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.900