DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CATSPER2 and cch1

DIOPT Version :9

Sequence 1:	NP_001269239.1	Gene:	CATSPER2 / 117155	HGNCID:	18810	Length:	534	Species:	Homo sapiens
Sequence 2:	NP_593894.1	Gene:	cch1 / 2542812	PomBaseID:	SPAC6F6.01	Length:	1854	Species:	Schizosaccharomyces pombe

Alignment Length:	347	Identity:	74/347 - (21%)
Similarity:	143/347 - (41%)	Gaps:	68/347 - (19%)

- Green bases have known domain annotations that are detailed below.

Human   163 FIL--EILLK---WLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGVTGQSV---WLQLLRICR 219
            |:|  |::|:   :|.::.:|::...|:.|.|:.:|:|   |.:|..:....|   ||.:..|.|
pombe   557 FLLAAEVILRFFAYLPDYRLFFRRYTNLVDIVLAVLNL---VTLLPSIRKNPVAFGWLSIFAIAR 618

Human   220 VLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFSEYTRSPRQDLEYHV 284
            :.|.:.|:...|:   |..:|....|.:..|::.|:|..:|.::..|.:|.:.......| :..:
pombe   619 IYRCILLIPYTRK---IAKLLFSNFKQLLNLMLFLVIVLFIASLCAVRLFQDLPNDGDSD-DDAI 679

Human   285 FFSDLPNSLVTVFILFTLDHW----------YALLQDVWKVPEVSRIFSSIYFILWLLLGSIIFR 339
            .|:....|.:.::.:.|.::|          .|.|...| :|       ..:|.||.|..:.:..
pombe   680 SFATTYESFLYMYQILTSENWTDVMFAIQARLAHLHLSW-IP-------GAFFTLWFLFSNNVVL 736

Human   340 SIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKNMSHEALTSSHSKIEDRGASQQ 404
            |:.:|::..||           |..|..||.:..|..:.:..:|.:....:.:.:.:..|..|::
pombe   737 SMFIAVIQVNF-----------APSESDLKMEQLKMYLARLLRNYNPFQASLTLNALIKRNGSRK 790

Human   405 RESLDLSEVSEVESNYGATEEDLITSASKTEETLSKKREYQSSSCVSSTSSSYSSS--------- 460
            .:::|       ||:|....||.|.........:..|...:.|...|...|.||.:
pombe   791 GKTVD-------ESHYEWLYEDNIIKGFLRVTNIPPKEPLKPSLDTSPELSKYSLAKLSNNFKRF 848

Human   461 -------SESRFSESIGRLDWE 475
                   |::.|...|| :.||
pombe   849 VMRDDPFSQAYFKRVIG-IRWE 869

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CATSPER2	NP_001269239.1	Ion_trans	178..356	CDD:278921	42/190 (22%)
cch1	NP_593894.1	Ion_trans	201..485	CDD:278921
		Ion_trans	533..748	CDD:278921	47/216 (22%)
		Ion_trans	968..1220	CDD:278921
		Ion_trans	1289..1517	CDD:278921
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG2301
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900