DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CATSPER2 and Catsper2

DIOPT Version :9

Sequence 1:	NP_001269239.1	Gene:	CATSPER2 / 117155	HGNCID:	18810	Length:	534	Species:	Homo sapiens
Sequence 2:	NP_694715.2	Gene:	Catsper2 / 212670	MGIID:	2387404	Length:	588	Species:	Mus musculus

Alignment Length:	593	Identity:	371/593 - (62%)
Similarity:	438/593 - (73%)	Gaps:	76/593 - (12%)

- Green bases have known domain annotations that are detailed below.

Human    11 QQEEQMQLPRADAIRSRLIDTFSLIEHLQGLSQAVPRHTIRELLDPSRQKKLVLGDQHQLVRFSI 75
            |::...||.|||||||:||||||||||||||||||||||:||:||||.|:||:.|||.|||||||
Mouse     3 QEQGHFQLLRADAIRSKLIDTFSLIEHLQGLSQAVPRHTLREILDPSYQQKLMSGDQEQLVRFSI 67

Human    76 KPQRIEQISHAQRLLSRLHVRCSQRPPLSLWAGWVLECPLFKNFIIFLVFLNTIILMVEIELLES 140
            ||:|:..|:|::||||||.||||:.|||||||||||:..:|..|||.|:||||.:|||||||:||
Mouse    68 KPRRMGHITHSRRLLSRLRVRCSRMPPLSLWAGWVLDSSVFSKFIISLIFLNTFVLMVEIELMES 132

Human   141 TNTKLWPLKLTLEVAAWFILLIFILEILLKWLSNFSVFWKSAWNVFDFVVTMLSLLPEVVVLVGV 205
            |||.|||:||.||||.|||||.||:||||.||::||:|||.|||||||.||:||||||:|||:||
Mouse   133 TNTALWPVKLALEVADWFILLSFIVEILLMWLASFSLFWKDAWNVFDFFVTLLSLLPELVVLLGV 197

Human   206 TGQSVWLQLLRICRVLRSLKLLAQFRQIQIIILVLVRALKSMTFLLMLLLIFFYIFAVTGVYVFS 270
            ...||||||||:|||||||||.|:||||::|:|.||||||||||||||||||||||||||||.|.
Mouse   198 PAHSVWLQLLRVCRVLRSLKLFARFRQIKVILLALVRALKSMTFLLMLLLIFFYIFAVTGVYFFR 262

Human   271 EYTRSPRQDLEYHVFFSDLPNSLVTVFILFTLDHWYALLQDVWKVPEVSRIFSSIYFILWLLLGS 335
            ||:||..:.|||::|||||.|||||||||||||||||:|||:|||||.||:|||||.||||||||
Mouse   263 EYSRSTIEGLEYNMFFSDLLNSLVTVFILFTLDHWYAVLQDIWKVPESSRVFSSIYVILWLLLGS 327

Human   336 IIFRSIIVAMMVTNFQNIRKELNEEMARREVQLKADMFKRQIIQRRKN-----------MSHEAL 389
            ||||:||||||||||||||.||:|||:..|||.||||||:||||||::           :|.:.:
Mouse   328 IIFRNIIVAMMVTNFQNIRSELSEEMSHLEVQYKADMFKQQIIQRRQHSESLRGTSLGKVSEDII 392

Human   390 TSSHSKIED----------------------RGASQQRESLDLSEVSEVESNYGA---TEEDLIT 429
            .:|.:..:|                      .|...:.|..| ||.||.|::...   .|:|...
Mouse   393 ETSDASDDDDDDDDDDDDDDDDDDKSDATESDGEKNENEESD-SENSESENSESEKIDPEKDYAK 456

Human   430 SA--------------------------------SKTEETLSKKREYQSSSCVSSTSSSYSSSSE 462
            .:                                .:.|...||::.|..|..:||..   |::::
Mouse   457 KSYPEKSHPEKSYPEKSHPEKSYPEKSHPKKSYDEQAEAEESKEKAYPVSHSISSHG---STAAD 518

Human   463 SRFSESIGRLDWETLVHENLPGLMEMDQDDR-VWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQ 526
            :.|.|:   |||||||||||||||:|||||| |||||||||||||||||||||||||||||||||
Mouse   519 TAFLEN---LDWETLVHENLPGLMDMDQDDRIVWPRDSLFRYFELLEKLQYNLEERKKLQEFAVQ 580

Human   527 ALMNLEDK 534
            |||:.|||
Mouse   581 ALMSFEDK 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CATSPER2	NP_001269239.1	Ion_trans	178..356	CDD:278921	146/177 (82%)
Catsper2	NP_694715.2	Ion_trans	105..350	CDD:366146	192/244 (79%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C83951835
Domainoid	1	1.000	389	1.000	Domainoid score	I11740
eggNOG	1	0.900	-	-		E1_KOG2301
HGNC	1	1.500	-	-
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H77423
Inparanoid	1	1.050	659	1.000	Inparanoid score	I9783
Isobase	0	0.000	Not matched by this tool.
NCBI	1	1.000	-	-
OMA	1	1.010	-	-		QHG50839
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0015379
OrthoInspector	1	1.000	-	-		oto120884
orthoMCL	1	0.900	-	-		OOG6_112823
Panther	1	1.100	-	-	LDO	PTHR46923
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X12220
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	15.300