DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Kcnc3 and Shawl

DIOPT Version :9

Sequence 1:	NP_446449.2	Gene:	Kcnc3 / 117101	RGDID:	621358	Length:	769	Species:	Rattus norvegicus
Sequence 2:	NP_001097131.2	Gene:	Shawl / 5740840	FlyBaseID:	FBgn0085395	Length:	937	Species:	Drosophila melanogaster

Alignment Length:	792	Identity:	276/792 - (34%)
Similarity:	372/792 - (46%)	Gaps:	219/792 - (27%)

- Green bases have known domain annotations that are detailed below.

  Rat    91 KIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARFDYDPGTDEFFFDRHPGVFAYVLNYYRT 155
            :|::||.|:|:|||::||:.:|.|||:.|||    |..:|||..:|:|||||||||..:||||||
  Fly     6 RIILNVSGIRYETYKATLKKIPATRLSRLTE----ALANYDPVLNEYFFDRHPGVFTQILNYYRT 66

  Rat   156 GKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAEEALDSFEAPDSSGNANANAGGA 220
            ||||.|.|||||||||||.|||:|...||.|||.||..|||.:..|...:..|...........|
  Fly    67 GKLHYPTDVCGPLFEEELEFWGLDSNQVEPCCWSTYSIHRDTQNTLAILDKLDIENEKPTEEQIA 131

  Rat   221 HDAGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGGPAGGPGGAGGTWWRRWQPRVWALFEDPY 285
            ...|.::..         :.|||.  |                      |:|.:|::||:|::|.
  Fly   132 RLFGFEEAL---------SNGELN--C----------------------WQRIKPKIWAMFDEPS 163

  Rat   286 SSRAARYVAFASLFFILISITTFCLETHEGF-IHISNKTVTQASPIPGAPPE------------- 336
            ||..|:.||..|:|||.:|:.:|||:||.|| :.:.:.......|..|.||.
  Fly   164 SSTGAKIVAGMSVFFIFVSVISFCLKTHPGFRVDLPSGAHDAHGPGAGGPPHGHDPMGEPPQTHQ 228

  Rat   337 -----------------NITN-----------------------------------------VE- 342
                             .:||                                         :|
  Fly   229 YHQHSITPPSGSIGPTFRVTNYTSYSSGNFTASGQATPIATIKGGQRQRLKRNINGSILNEFIEE 293

  Rat   343 -------------VET-----EPFLTYVEGVCVVWFTFEFLMRVTFCPDKVEFLKSSLNIIDCVA 389
                         :||     |.|. |||.||.|||..|.::|:...|:..:|:||.:||||..|
  Fly   294 KILGHNGRRKHGWIETYGQPHEAFF-YVELVCNVWFFIEVIIRLIVSPNLWQFIKSPVNIIDFTA 357

  Rat   390 ILPFYLEVGLSGLSSKAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLII 454
            .|.||.:|      .:...:..|.|.....|||:|:||||||..|||:|.||.:||..|..||:.
  Fly   358 TLSFYTDV------MQRMGEYTGLLEAFSIVRIMRLFKLTRHSPGLRILIHTFKASAKELTLLVF 416

  Rat   455 FLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGML 519
            ||.||::.||::.||||::..:||:       .||:||:|.|||:|||||:||||:.|||:.||.
  Fly   417 FLVLGIVFFASLAYYAEKLQDNPDN-------QFKSIPLGLWWAIVTMTTVGYGDVAPKTYPGMF 474

  Rat   520 VGALCALAGVLTIAMPVPVIVNNFGMYYSLAMAKQKLPKKKNKHIPRPPQPGSPNYCKPDPPPPP 584
            ||||||||||||||:||||||:||.|:||...|:.|||||:.:.:| ..||....         .
  Fly   475 VGALCALAGVLTIALPVPVIVSNFSMFYSHTQARSKLPKKRRRVLP-VEQPRRKR---------E 529

  Rat   585 PPHPHHG-SGGISPPPPITPPSM---GVTVAGAYPPG------PHTHPGL-----LRGGA----- 629
            |..||.| :..|...|| |.|.:   ||...||..||      .|:..|.     ..|||
  Fly   530 PTAPHRGRTNAIKQTPP-TGPGLVAGGVVPVGAGGPGLGGHAVGHSAAGAPMFKDAFGGAKIGTV 593

  Rat   630 --GGLGIMGLPPLPAPGEPCPLAQEEVIETNRADPRPNGDPAAAALAHEDCPAIDQPAMSPEDKS 692
              .|:.::||.|.........:|.      |.|||.|     .:||.::      .|.:.|   :
  Fly   594 NVNGVNVIGLHPAQRTTTTMAMAM------NEADPTP-----MSALTYQ------VPMLQP---T 638

  Rat   693 PITPGSRGRYSRDRACFLVTDYAPSPDGSIRKGYEKSRSLSSIVGLSGVSLRLAPLATPPGSPRA 757
            | ||.....::...|..|    .|:           |.:::|...|:| |...|.:||
  Fly   639 P-TPAHSHGHAHGHAHGL----GPA-----------SAAMTSSASLTG-SAASAAVAT------- 679

  Rat   758 TRRAPPTLPSIL 769
            ...|.|..||.:
  Fly   680 AAAAAPAGPSFI 691

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Kcnc3	NP_446449.2	BTB	92..194	CDD:197585	64/101 (63%)
		BTB_2	92..186	CDD:280393	59/93 (63%)
		Ion_trans	344..551	CDD:278921	109/211 (52%)
		Ion_trans_2	460..541	CDD:285168	49/80 (61%)
Shawl	NP_001097131.2	BTB	7..99	CDD:197585	60/95 (63%)
		BTB_2	7..97	CDD:280393	59/93 (63%)
		Ion_trans	307..506	CDD:278921	109/212 (51%)
		Ion_trans_2	<449..499	CDD:285168	39/49 (80%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	255	1.000	Domainoid score	I1967
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	460	1.000	Inparanoid score	I1505
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D331021at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11537
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X19
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	7	7.160