DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCYAP1R1 and adcyap1r1a

DIOPT Version :9

Sequence 1:	NP_001186564.1	Gene:	ADCYAP1R1 / 117	HGNCID:	242	Length:	496	Species:	Homo sapiens
Sequence 2:	NP_001013462.1	Gene:	adcyap1r1a / 541315	ZFINID:	ZDB-GENE-050315-1	Length:	479	Species:	Danio rerio

Alignment Length:	496	Identity:	359/496 - (72%)
Similarity:	403/496 - (81%)	Gaps:	35/496 - (7%)

- Green bases have known domain annotations that are detailed below.

Human     9 LAALLLLPMAPAMHSD---CIFKKEQAMCLEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVG 70
            |...|::.:...:||:   |:.|:|:..|||:|...:..   :|....||..|||:|||:.|.||
Zfish    11 LILFLIISLMWPIHSEISNCVIKREEERCLERIALHDPK---DDQKFECPWEWDNLTCWQAASVG 72

Human    71 EMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNCTEDGWSEPFPHYFDACG 135
            ::|.|:|||||...:|::                     .:|.:||||||.|||||:|||.|||.
Zfish    73 DVVEVNCPELFEFMSPEE---------------------GLGKISRNCTEFGWSEPYPHYVDACM 116

Human   136 FDEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRA 200
            .||   .|...|.||.|||||||||||||||:|||||||||||||||||||||||||||||:|||
Zfish   117 TDE---NTTKPDMYYASVKALYTVGYSTSLVSLTTAMVILCRFRKLHCTRNFIHMNLFVSFILRA 178

Human   201 ISVFIKDWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRY 265
            |||||||.:||||:||:|||:.||.||||||||||||:|||||||||||||||||||||||||||
Zfish   179 ISVFIKDGVLYAEEDSDHCFVHTVGCKAVMVFFHYCVMSNYFWLFIEGLYLFTLLVETFFPERRY 243

Human   266 FYWYTIIGWGTPTVCVTVWATLRLYFDDTGCWDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVI 330
            |||||||||||||:|||:||.|||:|||:|||||||:||||||||||||.|||:|||||||||:|
Zfish   244 FYWYTIIGWGTPTICVTIWAVLRLHFDDSGCWDMNDNTALWWVIKGPVVASIMINFVLFIGIIII 308

Human   331 LVQKLQSPDMGGNESSIYFSCVQKCYCKPQRAQQHSCKMSELSTITLRLARSTLLLIPLFGIHYT 395
            |||||||||:||||||||.||.|||:.:|.:|.||||:|||||||||||||||||||||||||||
Zfish   309 LVQKLQSPDIGGNESSIYLSCAQKCFSEPTQAVQHSCRMSELSTITLRLARSTLLLIPLFGIHYT 373

Human   396 VFAFSPENVSKRERLVFELGLGSFQGFVVAVLYCFLNGEVQAEIKRKWRSWKVNRYFAVDFK-HR 459
            |||||||:.||||||||||||||||||||||||||||||.|:|||||||||.||||||||.| .|
Zfish   374 VFAFSPEDFSKRERLVFELGLGSFQGFVVAVLYCFLNGEAQSEIKRKWRSWTVNRYFAVDLKQQR 438

Human   460 HPSLASSGVNGGTQLSILSKSSSQIRMSGLPAD----NLAT 496
            ||||||||||||||||||||||||||||...|:    ||.|
Zfish   439 HPSLASSGVNGGTQLSILSKSSSQIRMSSPLAETVNLNLPT 479

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCYAP1R1	NP_001186564.1	HRM	52..137	CDD:308439	37/84 (44%)
		7tmB1_PACAP-R1	150..445	CDD:320653	260/294 (88%)
		TM helix 1	152..177	CDD:320653	23/24 (96%)
		TM helix 2	186..208	CDD:320653	20/21 (95%)
		TM helix 3	227..254	CDD:320653	25/26 (96%)
		TM helix 4	266..286	CDD:320653	17/19 (89%)
		TM helix 5	302..331	CDD:320653	24/28 (86%)
		TM helix 6	347..402	CDD:320653	45/54 (83%)
		TM helix 7	407..432	CDD:320653	24/24 (100%)
adcyap1r1a	NP_001013462.1	HRM	56..118	CDD:280888	37/82 (45%)
adcyap1r1a	NP_001013462.1	7tm_2	128..402	CDD:278432	241/273 (88%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194342174
Domainoid	1	1.000	466	1.000	Domainoid score	I3297
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H870
Inparanoid	1	1.050	693	1.000	Inparanoid score	I4336
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D199589at7742
OrthoFinder	1	1.000	-	-		FOG0011671
OrthoInspector	1	1.000	-	-		oto43285
orthoMCL	1	0.900	-	-		OOG6_118996
Panther	1	1.100	-	-	LDO	PTHR45620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	12	12.400