Protein Alignment ADCYAP1R1 and Pdfr

DIOPT Version :10

• Sequence 1: NP_001186564.1
• Gene: ADCYAP1R1 / 117
• HGNCID: 242
• Length: 496
• Species: Homo sapiens
• Sequence 2: NP_001245501.1
• Gene: Pdfr / 31234
• FlyBaseID: FBgn0260753
• Length: 738
• Species: Drosophila melanogaster
• Alignment Length: 445
• Identity: 114/445 - (25%)
• Similarity: 190/445 - (42%)
• Gaps: 105/445 - (23%)

Human    54 CPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQVWETETIGESDFGDSNSLDLSDMGVVSRNC 118
            |...||.:.||.|...|.:..::||                      |..:.:|.....:  |.|
  Fly   216 CNWTWDTLLCWPPTPAGVLARMNCP----------------------GGFHGVDTRKFAI--RKC 256

Human   119 TEDG-W-SEPFPHYFDACGFDEY-----------ESETGDQDY-YYLSV----KALYTVGYSTSL 165
            ..|| | |.|.....:..|:.:|           ..:.|.:|: .|:.:    :.|..||...||
  Fly   257 ELDGRWGSRPNATEVNPPGWTDYGPCYKPEIIRLMQQMGSKDFDAYIDIARRTRTLEIVGLCLSL 321

Human   166 VTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLRAI---SVFIKDWILYAEQDSNHCFISTVE-- 225
            ..|..:::|.|.||.|...|..||.||||:.:|:.|   ::::..:....::.:.:..:|.:|
  Fly   322 FALIVSLLIFCTFRSLRNNRTKIHKNLFVAMVLQVIIRLTLYLDQFRRGNKEAATNTSLSVIENT 386

Human   226 ---CKAVMVFFHYCVVSNYFWLFIEGLYLFTLLVETFFPERRYFYWYTIIGWGTPTVCVTVWATL 287
               |:|..|...|...:.:.|:|||||||..::....|.......:::.:||..|.:..||||..
  Fly   387 PYLCEASYVLLEYARTAMFMWMFIEGLYLHNMVTVAVFQGSFPLKFFSRLGWCVPILMTTVWARC 451

Human   288 RLYFDDTG---C-WDMNDSTALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIY 348
            .:.:.||.   | |:.| .|..:|:::||.:..|::||...:.||.:||.||
  Fly   452 TVMYMDTSLGECLWNYN-LTPYYWILEGPRLAVILLNFCFLVNIIRVLVMKL------------- 502

Human   349 FSCVQKCYCKPQRAQQHSCKMSELSTI--TLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLV 411
                               :.|:.|.|  |.:..|:.::|:||.||...:...:|...: ....|
  Fly   503 -------------------RQSQASDIEQTRKAVRAAIVLLPLLGITNLLHQLAPLKTA-TNFAV 547

Human   412 FELG---LGSFQGFVVAVLYCFLNGEVQAEIKR------------KWRSWKVNRY 451
            :..|   |.|||||.:|::||||||||:|.:.:            :|...:.:.|
  Fly   548 WSYGTHFLTSFQGFFIALIYCFLNGEVRAVLLKSLATQLSVRGHPEWAPKRASMY 602

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
ADCYAP1R1	NP_001186564.1	HRM	52..137	CDD:397086	19/84 (23%)
		7tmB1_PACAP-R1	150..445	CDD:320653	91/327 (28%)
		TM helix 1	152..177	CDD:320653	7/28 (25%)
		TM helix 2	186..208	CDD:320653	8/24 (33%)
		TM helix 3	227..254	CDD:320653	11/26 (42%)
		TM helix 4	266..286	CDD:320653	6/19 (32%)
		TM helix 5	302..331	CDD:320653	9/28 (32%)
		TM helix 6	347..402	CDD:320653	10/56 (18%)
		TM helix 7	407..432	CDD:320653	12/27 (44%)
Pdfr	NP_001245501.1	HRM	213..272	CDD:397086	18/79 (23%)
		7tmB1_PDFR	306..584	CDD:320389	89/311 (29%)
		TM helix 1	308..333	CDD:320389	7/24 (29%)
		TM helix 2	342..364	CDD:320389	8/21 (38%)
		TM helix 3	391..418	CDD:320389	11/26 (42%)
		TM helix 4	430..450	CDD:320389	6/19 (32%)
		TM helix 5	469..498	CDD:320389	9/28 (32%)
		TM helix 6	512..539	CDD:320389	7/26 (27%)
		TM helix 7	546..571	CDD:320389	12/24 (50%)