DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment ADCYAP1R1 and seb-3

DIOPT Version :9

Sequence 1:	NP_001186564.1	Gene:	ADCYAP1R1 / 117	HGNCID:	242	Length:	496	Species:	Homo sapiens
Sequence 2:	NP_510496.1	Gene:	seb-3 / 181598	WormBaseID:	WBGene00007664	Length:	454	Species:	Caenorhabditis elegans

Alignment Length:	514	Identity:	125/514 - (24%)
Similarity:	204/514 - (39%)	Gaps:	146/514 - (28%)

- Green bases have known domain annotations that are detailed below.

Human    26 IFKKEQAMC--LEKIQRANELMGFNDSSPGCPGMWDNITCWKPAHVGEMVLVSCPELFRIFNPDQ 88
            |.:.|.|.|  |:|::.::...|      ||...:|...||..||:|:.:...||..|....|
Worm     4 IIRAEYAACQELKKLENSSYNPG------GCSVDFDKSLCWASAHIGQQMTRDCPFTFCTAIP-- 60

Human    89 VWETETIGESDFGDSNSLDLSDMGVVSRNCTEDG-WSEPFPHY---------FDAC--GF----- 136
                           ...::.|..:|||||...| |.:  .:|         :..|  ||
Worm    61 ---------------GCEEIKDRYMVSRNCNSMGVWQD--SNYTMCIKVVEEYAQCLQGFCRVCP 108

Human   137 DEYESETGDQDYYYLSVKALYTVGYSTSLVTLTTAMVILCRFRKLHCTRNFIHMNLFVSFMLR-- 199
            |....         |.:....|:.: .|::.|..|:|:...|..:.|.|..||.||..:|:.|
Worm   109 DVLRD---------LVISVSLTLSF-VSVILLVAAIVLFSIFDSIQCRRLSIHKNLATAFVFRFA 163

Human   200 --AISVFIK-------------------DWILYAEQDSNHCFISTVECKAVMVFFHYCVVSNYFW 243
              ||...::                   :||                |||::.|..|..|::..|
Worm   164 VLAIWTIVQTTNVFQDCTRLTPLPLWDYEWI----------------CKAILWFVIYFNVASVMW 212

Human   244 LFIEGLYLFTLLVETFFPERRY---FYWYTIIGWGTPTVCVTVWATLRLYFD----DTGCWDMND 301
            :.|||.:|::..  |.|..|..   :..|...|||.|.|.||.||.:..|..    ::.||....
Worm   213 MLIEGAFLYSRF--TVFAMRHSDAPWSLYLACGWGVPFVVVTAWALVHQYISSQQTNSFCWLPYA 275

Human   302 STALWWVIKGPVVGSIMVNFVLFIGIIVILVQKLQSPDMGGNESSIYFSCVQKCYCKPQRAQQHS 366
            .....|::.|.:..::::|.:..:.|:|||||||::                          ::|
Worm   276 QGLHLWILAGTMGSALIMNLIFLLMIVVILVQKLRT--------------------------ENS 314

Human   367 CKMSELSTITLRLARSTLLLIPLFGIHYTVFAFSPENVSKRERLVFELG---LGSFQGFVVAVLY 428
            .:..::    .|..::||||:||.||......:.||:.|.    |:.||   |...||..:||||
Worm   315 AESKKI----WRTIKATLLLVPLLGISNIPLFYEPEHPSS----VYMLGSAILQHSQGIFIAVLY 371

Human   429 CFLNGEVQAEIKRK-----WRSWKVNRYFAVDFKHRHPSLASSGVNGGTQLSILSKSSS 482
            ||||.|:|..:||:     :..:|....|  :.:..:...|.:....|..:..::|:.:
Worm   372 CFLNSEIQGALKRQLSKVPFEFFKTRNRF--ETERTYVPEARNATKNGVPMEEMNKTKN 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
ADCYAP1R1	NP_001186564.1	HRM	52..137	CDD:308439	24/101 (24%)
		7tmB1_PACAP-R1	150..445	CDD:320653	88/332 (27%)
		TM helix 1	152..177	CDD:320653	5/24 (21%)
		TM helix 2	186..208	CDD:320653	8/44 (18%)
		TM helix 3	227..254	CDD:320653	10/26 (38%)
		TM helix 4	266..286	CDD:320653	9/19 (47%)
		TM helix 5	302..331	CDD:320653	5/28 (18%)
		TM helix 6	347..402	CDD:320653	10/54 (19%)
		TM helix 7	407..432	CDD:320653	12/27 (44%)
seb-3	NP_510496.1	HRM	27..90	CDD:280888	21/81 (26%)
seb-3	NP_510496.1	7tm_4	125..367	CDD:304433	74/293 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	128	1.000	Domainoid score	I3620
eggNOG	1	0.900	-	-		E1_KOG4564
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D290902at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm15533
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45620
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X66
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.920