DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ambp and Appl

DIOPT Version :9

Sequence 1:	NP_031469.1	Gene:	Ambp / 11699	MGIID:	88002	Length:	349	Species:	Mus musculus
Sequence 2:	NP_001245448.1	Gene:	Appl / 31002	FlyBaseID:	FBgn0000108	Length:	890	Species:	Drosophila melanogaster

Alignment Length:	281	Identity:	51/281 - (18%)
Similarity:	86/281 - (30%)	Gaps:	96/281 - (34%)

- Green bases have known domain annotations that are detailed below.

Mouse     4 LRTLFLLLTACLASRADPASTLPDIQVQENFSESRIY--------GKWY----NLAVGSTCPWLS 56
            ||:|:::| |...::...||...:.|:.......:||        |:|.    ....|.||
  Fly    11 LRSLWVVL-AIGTAQVQAASPRWEPQIAVLCEAGQIYQPQYLSEEGRWVTDLSKKTTGPTC---- 70

Mouse    57 RIKDKM-------------SVSTLV-----------LQEGATETEISMTSTRWRRGVCEEITGAY 97
             ::|||             .::.:|           .::||........|.||.:..  ...|.:
  Fly    71 -LRDKMDLLDYCKKAYPNRDITNIVESSHYQKIGGWCRQGALNAAKCKGSHRWIKPF--RCLGPF 132

Mouse    98 QKTDI---DGKFLYHKS---------KWNITLESYVVHTNYDEYAIFLTKKSSHHHGLTITAKLY 150
            |...:   :|....|..         :||                            .|..|...
  Fly   133 QSDALLVPEGCLFDHIHNASRCWPFVRWN----------------------------QTGAAACQ 169

Mouse   151 GREPQLRDSLLQEFKDVALNVGISENSIIFMPDRGECVPGDREVEPTSIARARRAVLPQESEGSG 215
            .|..|:|...:      .|..|||    :|......|.|...:.:...:.:....|:|.....|.
  Fly   170 ERGMQMRSFAM------LLPCGIS----VFSGVEFVCCPKHFKTDEIHVKKTDLPVMPAAQINSA 224

Mouse   216 TEPLITGTLKKEDSCQLNYSE 236
            .:.|:..  .::||...|||:
  Fly   225 NDELVMN--DEDDSNDSNYSK 243

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ambp	NP_031469.1	Lipocalin	41..185	CDD:278490	30/183 (16%)
		Kunitz_BPTI	230..281	CDD:278443	3/7 (43%)
		Kunitz_BPTI	285..337	CDD:278443
Appl	NP_001245448.1	A4_EXTRA	26..198	CDD:128326	36/216 (17%)
		APP_N	33..141	CDD:280358	19/114 (17%)
		APP_Cu_bd	143..198	CDD:289676	14/92 (15%)
		APP_E2	387..580	CDD:289677
		GBP_C	<629..682	CDD:303769
		APP_amyloid	834..887	CDD:287486
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4295
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900