DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alx4 and Rx

DIOPT Version :9

Sequence 1:	NP_031468.1	Gene:	Alx4 / 11695	MGIID:	108359	Length:	399	Species:	Mus musculus
Sequence 2:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	640	Identity:	151/640 - (23%)
Similarity:	209/640 - (32%)	Gaps:	284/640 - (44%)

- Green bases have known domain annotations that are detailed below.

Mouse    27 SREGSSPFR-----GF-PGGDKFG------------------TTFLSAGAKGQGFGDAK-SRARY 66
            :..|.:||.     || .||..:|                  ...|..||.|.....|. ..:.:
  Fly   262 THHGHAPFGYHNAFGFGQGGHGYGHPEEAAGNYLNSMHQMVEANQLQTGANGANPPPAPLPPSSF 326

Mouse    67 GAGQQDLAAPLESSSGARGSFNKFQPQPPT---PQPPP---------APPAPPAHLYLQRG---- 115
            |:.||.|||....:...:...:|:....||   |.|||         ||.||....|.:|.
  Fly   327 GSHQQHLAALAAQAQEQQNQHSKYAKSSPTGAGPPPPPGAYFMESQTAPVAPSQINYDERSMSSA 391

Mouse   116 ---------ACK---------TP-PDGSLKLQEGSGGHNAALQVPCYAKESNLGEPELP------ 155
                     |.|         || |.|.|..:..|.|      |.|...|..|...:||
  Fly   392 SDLEEDDDDAAKLQLDVTSPPTPSPRGQLAAKRKSAG------VFCDDNEPKLANGQLPGGNYGI 450

Mouse   156 -PDS---------------------------EPVGMDNSYLSVKETGAKGPQ---------DRAS 183
             |.|                           :..|..:.:   :.:|...|.         :|.:
  Fly   451 RPRSMEEVHHQQQSHHHQQQQQQQQQQQQLQQQQGFQHDF---RNSGNGNPNGNSNSGDHGERLN 512

Mouse   184 AEIPS----------PLEKTDSESN------------------KGKKRRNRTTFTSYQLEELEKV 220
            |:..|          .|.:|:|...                  |.|.||||||||:|||.|||:.
  Fly   513 ADSDSLVNGSCASSEDLNQTNSSEQGEKITSGSDDEGQDDNCAKKKHRRNRTTFTTYQLHELERA 577

Mouse   221 FQKTHYPDVYAREQLAMRTDLTEARVQVWFQNRRAKWRKRERFGQMQQVRTHFS----------- 274
            |:|:||||||:||:|||:.:|.|.||||||||||||||::|:...::...|||:
  Fly   578 FEKSHYPDVYSREELAMKVNLPEVRVQVWFQNRRAKWRRQEKSESLRLGLTHFTQLPHRLGCGAS 642

Mouse   275 ---------------------------TAYELPLLTRAENYAQIQN--------------PSWIG 298
                                       .:|..|.|:.|.....:.:              |..:|
  Fly   643 GLPVDPWLSPPLLSALPGFLSHPQTVYPSYLTPPLSLAPGNLTMSSLAAMGHHHAHNGPPPPHVG 707

Mouse   299 NNGAASPVPACVVPCDPVP------------------ACMSPHA-----------------H--- 325
            :.|...|.|....|...||                  :.|||||                 |
  Fly   708 HGGHGQPQPPPPPPPHGVPHPHGSHHVVPLSHLSPHLSRMSPHATSLGSPHHGVTPLGTPLHSSL 772

Mouse   326 PPGSGASSVS------------------------DFLSVSGAGSHVGQTHMGSLF--GAAGISPG 364
            ||.|.|::|:                        ..||:..|.|:.....:.|..  |:...:||
  Fly   773 PPSSTATTVAVSSSQSSSSSASLECSGPDVCMSPQNLSIGNADSNGDGRDLSSDLDAGSTSSNPG 837

Mouse   365 LN---------------GYEMNGEP-------------DRKTSSIAALRMKAKEH 391
            .:               |.:....|             |.:::|||.||:|||||
  Fly   838 SSLDKCAASANIELLDVGRDSPPPPPTPTGKGSSTPPTDMRSNSIATLRIKAKEH 892

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alx4	NP_031468.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	68..133		26/99 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	171..206		12/71 (17%)
		Homeobox	206..258	CDD:278475	38/51 (75%)
		OAR	375..392	CDD:281777	11/17 (65%)
		OAR. /evidence=ECO:0000255\|PROSITE-ProRule:PRU00138	379..392		10/13 (77%)
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	38/51 (75%)
Rx	NP_726006.3	OAR	876..892	CDD:281777	9/15 (60%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910