DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alx3 and Rx

DIOPT Version :9

Sequence 1:	NP_031467.1	Gene:	Alx3 / 11694	MGIID:	1277097	Length:	343	Species:	Mus musculus
Sequence 2:	NP_726006.3	Gene:	Rx / 37367	FlyBaseID:	FBgn0020617	Length:	904	Species:	Drosophila melanogaster

Alignment Length:	423	Identity:	123/423 - (29%)
Similarity:	161/423 - (38%)	Gaps:	119/423 - (28%)

- Green bases have known domain annotations that are detailed below.

Mouse     5 RCAPFSVG--PAAGPYAAAGDEAP-GP----------------QGTPDAAPHLH------PAP-P 43
            :.:|...|  |..|.|......|| .|                :...|.|..|.      |.| |
  Fly   352 KSSPTGAGPPPPPGAYFMESQTAPVAPSQINYDERSMSSASDLEEDDDDAAKLQLDVTSPPTPSP 416

Mouse    44 RG----PRLSRFPACGPLEPYLPEPAKPPAKYLQDLGPGP-VLNGGHFYEGSAEAEEKASKAASF 103
            ||    .|.|....|...||.|.....|...|    |..| .:...|..:.|...:::..:....
  Fly   417 RGQLAAKRKSAGVFCDDNEPKLANGQLPGGNY----GIRPRSMEEVHHQQQSHHHQQQQQQQQQQ 477

Mouse   104 PQLPV------DCR----GGPRDGPSNVQASPGPCLASLSVPLSPG-LPDSMELAKT-------- 149
            .||..      |.|    |.| :|.|| ....|..|.:.|..|..| ...|.:|.:|
  Fly   478 QQLQQQQGFQHDFRNSGNGNP-NGNSN-SGDHGERLNADSDSLVNGSCASSEDLNQTNSSEQGEK 540

Mouse   150 ---------------KSKKRRNRTTFSTFQLEELEKVFQKTHYPDVYAREQLALRTDLTEARVQV 199
                           |.|.|||||||:|:||.|||:.|:|:||||||:||:||::.:|.|.||||
  Fly   541 ITSGSDDEGQDDNCAKKKHRRNRTTFTTYQLHELERAFEKSHYPDVYSREELAMKVNLPEVRVQV 605

Mouse   200 WFQNRRAKWRKRERYGKMQEGRNPFTTAYD-------------------ISVLPRTDSHPQLQNS 245
            ||||||||||::|:...::.|...||....                   :|.||...||||   :
  Fly   606 WFQNRRAKWRRQEKSESLRLGLTHFTQLPHRLGCGASGLPVDPWLSPPLLSALPGFLSHPQ---T 667

Mouse   246 LWPS---PGSGSPGGPCLMSPEGIPSPCMSPYSHSHGNVA--------GFMGVPASPAAHPGIYS 299
            ::||   |       |..::|..:....::...|.|.:..        |..|.|..|...|.
  Fly   668 VYPSYLTP-------PLSLAPGNLTMSSLAAMGHHHAHNGPPPPHVGHGGHGQPQPPPPPPP--- 722

Mouse   300 IHGFPPALGGHSFEP----SPDGDYKSPSLVSL 328
             ||.|...|.|...|    ||.....||...||
  Fly   723 -HGVPHPHGSHHVVPLSHLSPHLSRMSPHATSL 754

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alx3	NP_031467.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..122		37/157 (24%)
		SP2	32..>141	CDD:281067	34/131 (26%)
		Homeobox	157..209	CDD:278475	36/51 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	309..343		8/24 (33%)
Rx	NP_726006.3	Homeobox	563..615	CDD:278475	36/51 (71%)
Rx	NP_726006.3	OAR	876..892	CDD:281777
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D454642at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.920