Protein Alignment MED12L and SRB8

DIOPT Version :10

• Sequence 1: XP_016861165.1
• Gene: MED12L / 116931
• HGNCID: 16050
• Length: 2197
• Species: Homo sapiens
• Sequence 2: NP_010004.1
• Gene: SRB8 / 850442
• SGDID: S000000677
• Length: 1427
• Species: Saccharomyces cerevisiae
• Alignment Length: 1405
• Identity: 245/1405 - (17%)
• Similarity: 452/1405 - (32%)
• Gaps: 441/1405 - (31%)

Human    22 PDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSAR-----NIVINPSKIGAYFSSILAEKL 81
            ||..|.:....||::.|..|.:||.:.| ....|..|||     ::|...:.:...|..|:  |:
Yeast    31 PDFKPWEHTAAEDQILANFVAKGFYHTP-MVNFESISARSSVHESLVTQSNILSQQFDKII--KI 92

Human    82 ------KLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKVPILSKKE 140
                  |:.:...|....|.....:...|...|.::.:|...|   .:..|..:.|.:|...|:.
Yeast    93 REDHINKIPSNSTTTLHGPGFQLPNRITLTDHRKETWLHELSS---SHTSLVKIGKFIPHGLKRR 154

Human   141 DVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKR-------QAPDPNL--EWTQISTRYLR 196
            .|........:|:.||.||||  |.|:........|||       .|...:|  :||.... |:.
Yeast   155 QVIEQCYLKFIPLKRAIWLIK--CCYFIEWKSNHKKKRSNAAGADDAISMHLLKDWTDTFV-YIL 216

Human   197 EQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWE----YNEKLAFHMFQEGMLEKHEYLTWILD 257
            |:|     .:.|.:...|         .|.::.|:    |..||..:.:...::.|..:..|:::
Yeast   217 EKL-----IFDMTNHYND---------SQQLRTWKRQISYFLKLLGNCYSLRLINKEIFHHWLVE 267

Human   258 VLEKIRPMDDDLLKLLLPLMLQYSDEFVQ---------SAYLSRRLAYFCARRLSLLLSDSPNLL 313
            .:.|:.  :.:.|.|.|.:::.:.::..|         :...|::..:|...:::.:|.....::
Yeast   268 FINKME--NFEFLPLSLHILMIFWNDICQIDTNAPVAATITSSQKEPFFLVTKITDMLLHKYYIV 330

Human   314 AAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLSC---------------------AQH 357
            :  |...||...|..|......      :.::|.....||.                     ..:
Yeast   331 S--SSKSMINDENYIINDIKKN------NKIKLNILKILSSLILKIFQEQSLEVFIFPTSNWEIY 387

Human   358 GPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDLLQVAPSSLPMPGGNTAFNQQVRA 422
            .||::               .:|.|..||:|....  ..|:|:.....||..       |..:|
Yeast   388 KPLLF---------------EIVSNADTNQNSDMK--KKLELISYRNESLKN-------NSSIR- 427

Human   423 RIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDSSNSMETLYHKI 487
                  ..|.....|.:.:.:...|::          ...|..:..:|.| |..:..::....:.
Yeast   428 ------NVIMSASNANDFQLTIVTCKQ----------FPKLSCIQLNCID-TQFTKLLDDNPTEF 475

Human   488 FWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKH--RAMAVAKLL-------EKRQAEIEAER 543
            .|......|    |.....:..|..|::...|...|  ....|||||       ::...|.:.|.
Yeast   476 DWPTYVDQN----PLTMHKIIQLILWSIHPSRQFDHYESNQLVAKLLLLRINSTDEDLHEFQIED 536

Human   544 CGESEVLDEKESISSSSLAGS----SLPVFQNVLLRFLDTQAPS------------LSDPNSECE 592
            ...|.|....::.|:.....|    ||....|:|:.:...:.|:            |.|.|.
Yeast   537 AIWSLVFQLAKNFSAQKRVVSYMMPSLYRLLNILITYGIIKVPTYIRKLISSGLLYLQDSND--- 598

Human   593 KVEFVNLVLLF-----------CEFIRHDVFSHDAYMCTLISRGDL-SVTASTRPRSPVGENADE 645
              :||::.||.           ...:..:|..:|.....:.:...| .:|...:.|....:..:.
Yeast   599 --KFVHVQLLINLKISPLMKSQYNMVLRNVMEYDVKFYEIFNFDQLVEITEQIKMRILSNDITNL 661

Human   646 HYSKDH-DVK-MEEQSIMAHM--GIDSGTT-----NIFD------EVDKSDFKTDFGSEFPIFSP 695
            ..||.. .:| |..:..::|:  ||.|...     .||.      ||....||   ..||.::..
Yeast   662 QLSKTPLSIKIMVAEWYLSHLCSGILSSVNRTVLLKIFKIFCIDLEVFHHFFK---WIEFIVYHQ 723

Human   696 MPG--ESCENA----------------NTSLGRRMSVNCEKLVKREKPRELIFPSNYDLLRHLQ- 741
            :..  ||.|..                :..|..:..:...|.|.:||.    .|: |::...:.
Yeast   724 LLSDIESLEALMDILLCYQKLFSQFINDHILFTKTFIFIYKKVLKEKD----VPA-YNVTSFMPF 783

Human   742 ---YATHFPIPLDESSSHECNQRTILLYGVGKERDEARHQLKKITKDILKI-------------- 789
               :..:||..|...     |...|.|..|..:......:||....::||:
Yeast   784 WKFFMKNFPFVLKVD-----NDLRIELQSVYNDEKLKTEKLKNDKSEVLKVYSMINNSNQAVGQT 843

Human   790 --------------LNKKSTTETGVGDEGQKARKN----------KQETFPTL---ETVFTKLQL 827
                          |:.....:|....:.||||.|          :...|.::   ...||...|
Yeast   844 WNFPEVFQVNIRFLLHNSEIIDTNTSKQFQKARNNVMLLIATNLKEYNKFMSIFLKRKDFTNKNL 908

Human   828 LSYFDQHQVTSQISNNV--LEQITSFA------SGTSYHLPLAHHIQ---------LIFDLMEPA 875
            :.......:|.:::.||  ||.|....      :..||.|.|.:|.:         ::....|..
Yeast   909 IQLISLKLLTFEVTQNVLGLEYIIRLLPINLENNDGSYGLFLKYHKEQFIKSNFEKILLTCYELE 973

Human   876 LNINGLIDFAIQLLNELSVVEAELLLK-------SSSLAGSYTTGLCVC----------IVAVLR 923
            ...:|         ||..:...|:|||       |..|..:.|..:.:.          |:..:.
Yeast   974 KKYHG---------NECEINYYEILLKILITYGSSPKLLATSTKIIMLLLNDSVENSSNILEDIL 1029

Human   924 RYHSC--------------------LILNPDQTAQ-----------------------VFEGL-C 944
            .|.:|                    ::.|.|::..                       ||:.. |
Yeast  1030 YYSTCPSETDLNDIPLGSGQPDNDTVVTNDDKSDDDDHTVDEIDHVEYYVMMDFANLWVFQAFTC 1094

Human   945 GVVKHVVNPSECSSPERCILAYLY---------DLYVSCSHLRSKFGDL-------------FSS 987
            ..:|.::..:|.:.....:..:::         ||   ||.:..:..|:             |.:
Yeast  1095 FCIKKIMENNEPAMAMEDLKNFIFQIIEITNSNDL---CSQIFDQLKDMQTIEMITQIVEKDFCT 1156

Human   988 ACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSI---------------NYSMLGKI--- 1034
            :|.:            |:|.:.|.::::..||..::.|:               ||.:|.||
Yeast  1157 SCLQ------------NNNQKIDDNYIVVVIEIITSLSMRFQRETSGMIVISMENYHLLIKIIRQ 1209

Human  1035 ---LSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSE------LTACCTVLSS-------- 1082
               |::...::.....:.::.:...|||:.....||:.|::      :.:.|.:...
Yeast  1210 LSELNEGNLSKREIQIDAVLKIFSFHQDSIFQRIIADLSADKPTSPFIDSICKLFDKISFNLRLK 1274

Human  1083 ----EWLGVLKALCCSSNHVWGFNDVLCTVDVSDLSFHDS 1118
                |.|..||:....|:          |:|..  :||.|
Yeast  1275 LFLYEILSSLKSFAIYSS----------TIDAP--AFHTS 1302

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED12L	XP_016861165.1	Med12	106..161	CDD:462818	13/54 (24%)
		Med12-LCEWAV	283..765	CDD:463472	98/585 (17%)
		Med12-PQL	1837..2071	CDD:463471
SRB8	NP_010004.1	Med12	113..175	CDD:462818	14/64 (22%)