Protein Alignment MED12L and srb8

DIOPT Version :10

• Sequence 1: XP_016861165.1
• Gene: MED12L / 116931
• HGNCID: 16050
• Length: 2197
• Species: Homo sapiens
• Sequence 2: NP_001417945.1
• Gene: srb8 / 2543467
• PomBaseID: SPAC688.08
• Length: 1148
• Species: Schizosaccharomyces pombe
• Alignment Length: 1198
• Identity: 223/1198 - (18%)
• Similarity: 374/1198 - (31%)
• Gaps: 402/1198 - (33%)

Human   109 SQSAIHSWFSDLAGNK-PLSILAKKVPILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISE 172
            |:|....|...|:... |||.|.|.:|.....||:...|.|:.||..||.|.|:  ||   .::|
pombe   130 SESRRDRWLQGLSDPMVPLSSLIKTIPHGLWGEDILRMLVKFRVPFTRAIWFIR--CA---GVNE 189

Human   173 AK--IKKRQAPDPN---LEWTQISTRYLREQLAKISDFYHMASSTGDGPVPVPPEVEQAMKQWEY 232
            |:  ::|.|..|..   ..||.::..:|   ::.||.|.:             .::......:.|
pombe   190 ARSFLRKVQTTDITEWVKNWTDVAAGFL---ISFISSFLN-------------ADIYSFADDYTY 238

Human   233 NEKLAFHMFQEGMLEKHEYLTWILDVLEKIRPMDDDLLK--LLLPLMLQ-YSDEFVQSAYLSRRL 294
            ..||...:..|.::....:|..|:..      ..|..||  .|....|| :|...:|..::.|:.
pombe   239 LLKLFGRLLAEELVSPKHFLLRIVSF------SGDSSLKSFSLHFFALQFFSTSLIQYTHICRKC 297

Human   295 AYFCARRLSLLLSDSP-NLL--------AAHSPHMMIGPNNSSIGAPSPGPPGPGMSP-VQLAFS 349
            .....:....|:.|.| |||        .:|....:...|..|...|:....   :.| :.|.:.
pombe   298 VITILQSYQQLIVDQPANLLKFSLLSKKVSHFLFTLAQKNIESFFFPTEWDK---LKPTIILLWK 359

Human   350 DF------LSCAQ---------HGPLVYGLSCMLQTVTLCCPSALVWNYSTNENKSANPGSPLDL 399
            ||      ||..|         :.|:...:. .||.:: |....:.|.....           ||
pombe   360 DFPNYSTLLSIMQERNSKAMYMYKPVTSSIR-FLQIIS-CLSFPVGWRTLAK-----------DL 411

Human   400 LQVAPSSLPMPGGNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLE 464
            .::.|                   :|        .|..:.:.|..: |:...:|   .|......
pombe   412 FKLLP-------------------VY--------TGVPLLLHWCIN-CRSIFSG---DRNFIVSS 445

Human   465 VLDRHCFDRTDSSNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVA 529
            :.|...|||                              ..:|.|...:.:.......:..:|.|
pombe   446 IFDNANFDR------------------------------NLIVDLTLSFVLKLHPLEYNECVAAA 480

Human   530 KLLEKRQAEIEAERCGE---SEVLDEKESIS--SSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNS 589
            :||:...|      ||.   |:.:....|:.  ..|:..||          |:|.|...|
pombe   481 QLLDHLAA------CGYFFFSKYIARLASLGYLRESMLNSS----------FMDDQRKIL----- 524

Human   590 ECEKVEFVNL-VLLFCEFIRHDVFSHDAYMCTLISRGDLSVTASTRPRSPVGENADEH---YSKD 650
                   |.| :|...:.:::.::       .::|:|:..|..|.         .||:   :.:|
pombe   525 -------VQLPILRMSQQLKNKIY-------YILSKGNYFVDWSI---------CDEYVKRFKED 566

Human   651 HDVKMEEQSIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANTSLGRRMSVN 715
            |                              |...|..|         |:......||.:..|..
pombe   567 H------------------------------FSFMFKKE---------ENYAIITLSLVKIASTP 592

Human   716 CEKLVKREKPRELIFPSNYDLLRHL-----QYATHFPIPLDESSSHECNQRTILLYGVGK--ERD 773
            ..||.  |....::|..:|.:.:.:     ....||       |...|  ..|.||.:..  ..|
pombe   593 MSKLY--EDYLVMLFAFHYSMFQVMTKLIADNLVHF-------SFQSC--ALIFLYKISSYFVLD 646

Human   774 EARHQLKKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTS 838
                  .|:...|..::.|         .|.||...|:......:|..|:       :|...|
pombe   647 ------AKLFSSICSVVPK---------TESQKLLLNEMGKLFQVELNFS-------YDSPDV-- 687

Human   839 QISNNVLEQ---ITSFASGTS---------------------YH--LPLAHHIQLIF--DL---M 872
               |.::||   |||:.|...                     :|  ...:.|..:||  ||   :
pombe   688 ---NLLIEQFYEITSYESNYDDAFVEYKDATVANRKDFIEFLFHNITVSSKHTAVIFTSDLLMVL 749

Human   873 EPALNINGLIDFAIQLLNELSVVEAELLLKSSSLAGSYTTGLCVCIVA---VLRRYHSCLILNPD 934
            :.|||.....|       :|:......|||...           |.:.   .:.:::.|.:|:.|
pombe   750 KIALNHPPYFD-------DLATTTFSSLLKRDE-----------CTILSFFKILQFYGCKLLSVD 796

Human   935 QTAQVFEGLCGVVKHVVNPSECSSPERCILAYLYDL------YVSCSHLRS-------------- 979
            |       :..||..|....:.::..:....||.|.      |:...|.||
pombe   797 Q-------IWAVVSDVYEAQDNNTTLKQFFNYLLDESTWPEGYLEERHWRSILCKEARKHDSGLK 854

Human   980 --KFGDLFSSACSKVKQTIY-----------NNVMPANSNLR-WDPDFMMDFIENPSARSINYSM 1030
              |.|....:...::.:||:           :.|:|....|| ....||:|..:......:..::
pombe   855 LFKLGIKLCTRNEQIMKTIWSFIHVHDCNVISEVIPDQRFLRTLTEHFMIDLRQLDIVTCLKKAL 919

Human  1031 LGKILSDNAANRYSFVCNTLMNVCMGHQDAGRINDIANFSSELTACCTVLSSEWLGVLKALCCSS 1095
            :  .|.:.:|..|:....||     ...:...:.|.......|.:.....|..|..||..|   .
pombe   920 V--TLDEFSAPLYATWLTTL-----DDDELSELTDDVVQKKVLESLDNYKSGIWKLVLSGL---P 974

Human  1096 NHVWGFNDVLCTVDVSDLSFHDSL---ATFIAILIARQCFSLEDV-----VQHVALP-------- 1144
            |....|..:|.      .|..:.|   |.|:..||....:.:|.|     ::.:..|
pombe   975 NCKTVFEHLLL------FSLEERLDLPAAFLQDLIGASAYVMEQVPDSWFLEKLPCPLTQSLQSF 1033

Human  1145 SLLAAACGDADAEPGARMT--CRLLLHL 1170
            |.|:......|:...:|:|  |.|:||:
pombe  1034 SHLSNHIEVLDSTRQSRLTFLCHLILHM 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED12L	XP_016861165.1	Med12	106..161	CDD:462818	19/52 (37%)
		Med12-LCEWAV	283..765	CDD:463472	83/520 (16%)
		Med12-PQL	1837..2071	CDD:463471
srb8	NP_001417945.1	Med12	127..183	CDD:462818	19/52 (37%)