Protein Alignment MED12L and dpy-22

DIOPT Version :10

• Sequence 1: XP_016861165.1
• Gene: MED12L / 116931
• HGNCID: 16050
• Length: 2197
• Species: Homo sapiens
• Sequence 2: NP_509645.1
• Gene: dpy-22 / 181194
• WormBaseID: WBGene00001081
• Length: 3498
• Species: Caenorhabditis elegans
• Alignment Length: 2661
• Identity: 506/2661 - (19%)
• Similarity: 899/2661 - (33%)
• Gaps: 834/2661 - (31%)

Human     7 LSYEQRPLKRPRLGPPDVYPQDPKQKEDELTAVNVKQGFNNQPAFTGDEHGSARNIVINP---SK 68
            :.:|..|...|.|........:.|:.|.:....|..:..:.:...:.|||.:..::.|||   ..
 Worm   526 IDFESSPSASPALSVDKENECEKKEDESKTKEKNKDKEKDKEKEKSVDEHTNDLDVPINPDDAEM 590

Human    69 IGAYFSSILAEKLKLNTFQDTGKKKPQVNAKDNYWLVTARSQSAIHSWFSDLAGNKPLSILAKKV 133
            ..|...:..:||.||...:.|||:.     :|:....||::.::..
 Worm   591 ADANDKTDASEKQKLVEEEPTGKEN-----EDDTSSKTAKTSTSAE------------------- 631

Human   134 PILSKKEDVFAYLAKYSVPMVRATWLIKMTCAYYSAISEAKIKKRQAPDPNLEWTQISTRYLREQ 198
                          |...|.:              ..|..||.|    :||...|.      .::
 Worm   632 --------------KSEAPSI--------------VDSNDKIDK----EPNASSTS------NDE 658

Human   199 LAKISDFYHMASS--------------TGDGPVPV--PPEVEQAMKQWEYNEKLAFHMFQEGMLE 247
            .:| .|...|.|.              |.:.|:.|  .|||:::.|:.|.:
 Worm   659 TSK-DDTVPMESDPPAATEKPKESTEITTEEPLEVDKAPEVDKSEKEHEDD-------------- 708

Human   248 KHEYLTWILDVLEKIRPMDDD---LLKLLLPLMLQ---------------------YSDEFVQSA 288
                    :.::|..:..|:|   ::.::.|...|                     .:|...:..
 Worm   709 --------IMIIESNKKADEDDCVVIAVVDPDQEQTPESEKKKDGEEERDKNKDTDVADNEPEKI 765

Human   289 YLSRRLAYFCARRLSLLLSDSPNLLAAHSPHMMIGPNNSSIGAPSPGPPGPGMSPVQLAFSDFLS 353
            |....||....|:...:...:   ||:|....|:............|            :.....
 Worm   766 YTDEELAEIKIRKEKEMKIAT---LASHIKEKMVSDKKWKEKTSHAG------------WRTLDQ 815

Human   354 CAQHGPLVYGLSCMLQTVTLCCPSALVWN-YSTNENKSANP------GSPLDLLQVAPSSLPMPG 411
            |:|....::.||.|:|.:....|.:.||| .|..:.:..:.      |||||.|......||:..
 Worm   816 CSQFSEALHLLSSMVQYMACVTPESFVWNDLSVQQEERRHRILPQLCGSPLDYLPCELHKLPVME 880

Human   412 GNTAFNQQVRARIYEVEQQIKQRGRAVEVRWSFDKCQESTAGVTISRVLHTLEVLDRHCFDRTDS 476
            |.......:|.|..|    |.:|.:|.|.||..:.....:.|..|...:..:.::|.  .| .:.
 Worm   881 GVEEVVDCLRLRHCE----IVRRSQAAEDRWLPNAAFLQSFGRIIDTCVDVIGIMDN--ID-VEK 938

Human   477 SNSMETLYHKIFWANQNKDNQEVAPNDEAVVTLLCEWAVSCKRSGKHRAMAVAKLLEKRQAEIEA 541
            .|::.....::|...:..:.||..    ....|:.:|.::.:|.|..||..:||||.....:...
 Worm   939 PNAITNAGLRLFAFREKFEKQEAL----LKTMLMFKWCITEEREGSFRATYIAKLLRFGMDQNPE 999

Human   542 ERCGESEVLDEKESISSSSLAGSSLPVFQNVLLRFLDTQAPSLSDPNSECEKVEFVNLVLLFCEF 606
            ...|..:|:|                    :..:|:.|:.|.   ..|:..:..|.:.|.:..|.
 Worm  1000 NTIGGWQVMD--------------------LFFKFMSTEGPK---HGSKMYQAHFDSTVAIMIEM 1041

Human   607 IRHDVFSHDAYMCTLISRGDLSVTA--------------STRPRSPVGENADE----HYSKDHDV 653
            :|..:||....:..|....||...|              |.|.|.|  |..|:    |::.::..
 Worm  1042 MREKIFSITDILRELEKDSDLDYNAPLMERQRKQKIPKISKRHRKP--ETPDDTKLVHFTTEYTP 1104

Human   654 KMEEQSIMAHMGIDSGTTNIFDEVDKSDFKTDFGSEFPIFSPMPGESCENANTSLGRRMSVNCEK 718
            |                 .:|                                 :|::|.: .|:
 Worm  1105 K-----------------RLF---------------------------------MGKKMDL-LER 1118

Human   719 LVKREKPRELIFPSNYDLLRHLQYATHFPIPLDESSSHECNQRTILLYGVGKERD----EARHQL 779
            ::       :|.|.               :.:||.:. |...|.:||:|:....:    .||...
 Worm  1119 MI-------IILPQ---------------LDVDEDTD-EYRLRRLLLFGLKPAANVYFRRARAIY 1160

Human   780 KKITKDILKILNKKSTTETGVGDEGQKARKNKQETFPTLETVFTKLQLLSYFDQHQVTSQISNNV 844
            |.|||:....|..:....:.|....:|..:|:      |:.:..:.:..:|.|||.:..:|..|.
 Worm  1161 KSITKEFTTRLYIEFDRSSKVTTAHKKINQNR------LDDLLRQFRAQTYHDQHLILERIVYNF 1219

Human   845 LEQITSFASGTSYHLPLAHHIQLIFDLMEPALNINGLIDFAIQLLNE-LSVVEAELL-LKSSSLA 907
            ::.|..|.......:|......:|.::.|.:::|..:.|| .:::|. |..|:.::. .:...|.
 Worm  1220 IDGIGGFLKKNCDDVPAPEVANIICEMYEFSMDITSIFDF-FEMVNPYLKAVDDKIAHFRMDVLP 1283

Human   908 GSYTTGLCVCIVAVLRRYHSCLILNPDQTAQVFEGLCGVVKH----VVNPSECSSPERCILAYLY 968
            ..|.|                      :||.:|...  .:||    :::|..|:...:|.: .:.
 Worm  1284 DMYYT----------------------ETAFIFVSF--FMKHWQRFLLHPRACAIVNQCFV-LIQ 1323

Human   969 DLYVSCSHLRSKFGDLFSSACSKVKQTIYNNVMPANSNLRWDPDFMMDFIENPSARSI------- 1026
            |:..:..|:.:.:|...:......::.|.|..:.....|..|..|...|   |:|:.:
 Worm  1324 DMIRADDHMITCWGRTVAIFVFHARKAIANAGLQNEEFLAEDSHFWRVF---PNAQHVDLDVGYF 1385

Human  1027 -------------------NYSMLGKILSDNAAN------------RYSFVCNTLMNVCMGHQDA 1060
                               :|:....::|:...|            |||||....|......::.
 Worm  1386 NEDFAGVKLQLRGGTLRYDSYNDFKWLVSNMKPNLKKKPHLKRPNTRYSFVVRAFMEARQHGRNF 1450

Human  1061 GRINDIANFSSELTACCTVLSSEWLGVLKALC-CSSNHVWGFNDVLCTVDVSDLSFHDSLATFIA 1124
            .|||::||:.:.:||....||..|:|.:|.|| .|.:..:.|.::...:|:||.|.|.||.|||.
 Worm  1451 DRINELANYCANITANDPPLSEYWIGAIKGLCFLSLDAPYPFKEMSQQIDISDCSTHYSLTTFIT 1515

Human  1125 ILIARQCF----SLEDVVQHVALPSLL------------------AAACGD----ADAEPGARMT 1163
            .|..:..|    .|.::.:|| .|.:|                  |:...:    ::||||..:
 Worm  1516 CLAGKSAFYIPRLLAELTKHV-FPLMLRHDGRLTSQKTHDVKRKVASKTTESRTLSEAEPGVCL- 1578

Human  1164 CRLLLHLFRAPQACFLPQATGKPF------PGI-------RSSCDRHLLAAAHNSIEVGAVFAVL 1215
            |.|::        |.|.....:||      .||       .::.|..::...|......|:|..|
 Worm  1579 CLLII--------CGLCCVGDEPFGLSVHYRGIEKKKKRFNNTADERIMHLFHWFEMDHAMFRTL 1635

Human  1216 KAIMMLGDAKIGNNSVSSL---KNDDFTMRGLRCDGNADDIWTASQNPKSCGKSISIETANLR-E 1276
            ..|..|.:|.......::|   ||  |.::                ||....:.:..|.|..| :
 Worm  1636 GHISQLLEALQSRCRDANLVLPKN--FPIK----------------NPPKHQQELHREKAPYRPQ 1682

Human  1277 Y----ARYVLRTICQQEWVGEHCL-----KEPERLCTDKELILDPVLSNMQAQKLLQLICYPHGI 1332
            |    |:.|...||:|:||.....     ::.|....||      :..|...|::|::     .:
 Worm  1683 YLFNIAKTVQFVICEQDWVTLRMFRFFQTRKMEAFNQDK------LKQNCLGQQILRM-----AL 1736

Human  1333 KECTEGDNL----------QRQHIKRILQNLEQWTLRQSWLELQLMIKQCLKDPGS-----GSVA 1382
            :..||.:|:          ::..:.::|..:..|..|.:..:|.||||:...|..|     |::|
 Worm  1737 RRRTERENVHKLFEAHKISKKATVDKVLSFMNLWNFRATLFDLMLMIKEISPDGNSRHAQQGAIA 1801

Human  1383 EMNNLLDNIAKATIEVFQQSADLNNSSNSGMSLFNPNSIGSADTSSTRQNGIKTF--LSSSERRG 1445
             .:.|:..|.|...::|.                      ||..:..:....||.  ...|:...
 Worm  1802 -ADALMSEIGKCCRDMFL----------------------SAYKTKIKMPIAKTLTDFRLSDINK 1843

Human  1446 VWLVAPLIARLPT--------------SVQGRVLKAAGEELEKGQHLGSSSKKERDRQKQKSMSL 1496
            .||:|||:...|.              :|..:.|:.|...::    ...::.|||..|...:|
 Worm  1844 FWLIAPLVRMCPKPINIPPQYANTTVGTVAAKFLREAALLMD----TPPTTPKERLLQCSWAM-- 1902

Human  1497 LSQQPFLSLVLTCLKGQDEQR------EGLLTSLQNQV---NQILSNWREERYQDDIKARQMMHE 1552
             |:.||::::||||:.:..|:      :.|.|.||.:.   :...|||...|...|...
 Worm  1903 -SKVPFINMILTCLQCEKMQQSKDVFLQSLYTQLQRETLRDHHRRSNWTNRREHRDCTI------ 1960

Human  1553 ALQLRLNLVGGMFDTVQRSTQWTTDWALLLLQIITSGTVDMHTNNELFTTVLDMLGVLINGTLA- 1616
               .|:.|:|.::..:.::|...| |.||:.|::..|.::......::.|..|||..::..||.
 Worm  1961 ---FRITLIGYIYKEILKATHVET-WGLLIFQLMFHGIINPVREKLIYETCFDMLHHMVLWTLVD 2021

Human  1617 SDLSNASP--GGSEENKRAYMNLVKKLKKELGDK-RSESIDKVRQLLPLPKQTCDVITCEPMGS- 1677
            .|..|...  |........|..|:||::||:.:: ..::.:.:.:.||:.|.....|:.:....
 Worm  2022 GDSMNQHDRYGSIRVRWPQYAGLMKKIRKEMQERFTDQTRNSLHRFLPIGKMQMSTISYKKYQKR 2086

Human  1678 -LIDTKGNK--IAGFDSIDKKQGLQVSTKQKVSPWDLFEGQKNPAPL----SWAW--FGTVRVDR 1733
             .::.|.:|  :||....:.|.......|.|.   :.||...:...|    .|.:  |.|.|:|:
 Worm  2087 PKVNQKMSKKFLAGEGLKNGKYSFLPEEKAKT---NAFEHTDHLGDLIVKGGWKFRMFQTTRLDK 2148

Human  1734 RVIKYEEQHHLLLYHTHPMPKPRSYYL-----------------------QPLPLPPEEE----E 1771
            .....:......::|||.:...|...|                       ||:|:..|||    .
 Worm  2149 VAKNVQNVLRSNMHHTHVLEFNRPQLLMSDNMFDDIFLAPPDIEITKIIEQPVPVIDEEEAKKRA 2213

Human  1772 EEPTSPVSQEPERKSAELSDQGKTTTDEEKKTK-------------GRKRKTKSSSRVDEY---- 1819
            ||......::.|.|:|| .::.|...:.:|.||             |.|.|.|.:|:.|:.
 Worm  2214 EEEKEAAEKKEESKNAE-DEKNKNNAENKKDTKEGEKGKSKDKEKDGEKEKCKDASKKDDVTSEK 2277

Human  1820 ----------------PQSN--IYRVPPNYSPISSQMMHHPQSTLWGYNLVGQPQQPGFFLQNQS 1866
                            |::|  :....|..:|::    ..|.:...|          |...:|..
 Worm  2278 NELEKRASDAAAATNAPETNKDMDTSTPKPAPVT----RSPATRGRG----------GGRKRNSG 2328

Human  1867 LTPGG-------SRLDPAGSFVPTNTKQA-LSNMLQRRSG-----AMM--QPPSLHAITSQQQLI 1916
            ...||       ||.|.|.:...|....| ::|.....:|     ||.  |||..:..:.:.::.
 Worm  2329 ARGGGPRAKRANSRADTAQAAAATTQWNAPIANTSNPAAGGNFHAAMRGNQPPMSNGSSDETKVH 2393

Human  1917 QMKLLQQQQQQRLLRQAQTRPFQQDFCNSAVSLLEDFDNIMGQPGDQAALFAAQARPS-PQLPQY 1980
            ...||.::::::          :....:::.:......|.||.        .:...|| |.:|..
 Worm  2394 IRNLLNRKKEEK----------RNSLADASAAAAAANSNAMGN--------TSSMPPSGPPMPMG 2440

Human  1981 PGL------QQAQTMPQGYTMYGTQMPLQQT--SQQQAGSVVLSPSYNS---------RAYPAAH 2028
            ..:      ||.|.| |.:.|.|:...:.|.  ...|:.|....|.|:|         ..|...|
 Worm  2441 SSMQSAGATQQLQGM-QKHQMGGSMSGMNQNMGGMNQSMSHQAPPPYSSTNEMNRPLMNQYGGPH 2504

Human  2029 ------------SNPVLMERLRQIQQQP------------------------------------- 2044
                        |.||..|..:||.:|.
 Worm  2505 FAAPNPGPLNRSSGPVSSETRQQIMEQQMREKLAAHHQLVEQQKQRDAREREAREREAREHQERM 2569

Human  2045 --SGYV-QQQASPYLQPLTGSQRLNHQALQQSPLVGGGIDAVLTSAHPNLPSVP----------- 2095
              ..|: :||.....:.:..:.|:..:..::..:.....:|...:|.....:..
 Worm  2570 QREAYMKEQQLLERKRAIEENNRIMEEQQREREMEAARKEAARRAAEEAYAAEQQRLELLRRQEE 2634

Human  2096 --------------------LPQDPMR--------------------------------PRQPQV 2108
                                :.|:.||                                .||.:.
 Worm  2635 ERLRKEAEERMRIQRENEERVRQEQMRLEAEERERIRRAEEERIQKELEDKVRREKEEAARQEKE 2699

Human  2109 RQQQ--------------RLLQMQQPQQPQP----------QQPPQPQQSSQSQSQTLGLQAMQP 2149
            ||:|              :.::.|:..|..|          |.||..||||...:...|.|..||
 Worm  2700 RQEQEARMREAREAELSRQRMEQQRRSQQNPYMNQQGQYSQQPPPSYQQSSYPNNYQPGQQGNQP 2764

Human  2150 ---QQPLFPRQGLQQTQQ---QQQTAALVRQLQKQLSSNQ--PQQ------GVTPYGHPSH 2196
               |||  ..|.:||..|   ||.:..:...:|:|.:..|  |||      |:.....|.:
 Worm  2765 PNYQQP--SHQSMQQGHQAGYQQTSNQMQMNMQQQQNRQQGGPQQSFSGPGGINQPSQPGY 2823

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
MED12L	XP_016861165.1	Med12	106..161	CDD:462818	4/54 (7%)
		Med12-LCEWAV	283..765	CDD:463472	91/506 (18%)
		Med12-PQL	1837..2071	CDD:463471	54/318 (17%)
dpy-22	NP_509645.1	Med12	97..158	CDD:462818
		MDN1	<502..>781	CDD:444083	55/339 (16%)
		Med12-LCEWAV	815..>990	CDD:463472	45/185 (24%)
		DUF4670	<2516..2741	CDD:464815	24/224 (11%)
		MAP7	2624..2730	CDD:461709	10/105 (10%)
		Glutenin_hmw	<2687..3166	CDD:367362	36/139 (26%)