DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Abcd1 and Pmp70

DIOPT Version :9

Sequence 1:	NP_031461.1	Gene:	Abcd1 / 11666	MGIID:	1349215	Length:	736	Species:	Mus musculus
Sequence 2:	NP_001259732.1	Gene:	Pmp70 / 32992	FlyBaseID:	FBgn0031069	Length:	665	Species:	Drosophila melanogaster

Alignment Length:	643	Identity:	247/643 - (38%)
Similarity:	375/643 - (58%)	Gaps:	50/643 - (7%)

- Green bases have known domain annotations that are detailed below.

Mouse    56 EASGATATKAGMNRVFLQRLLALLRLLFPRVLCRETGLLALHSAALVSRTFLSVYVARLDGRLAR 120
            |.....|.||.:|.||.::|..||.:|.|.....|||||.|.:|||:.|:...:::.:....:..
  Fly    52 EKKDKKAGKAHVNSVFFKQLRQLLPILIPGFWSVETGLLFLVAAALIGRSVSDIWMIQNATVVES 116

Mouse   121 CIVRKDPRAFSWQLLQWLLIALPA-TFINSAIRYLEGQLALSFRSRLVAHAYGLYFSQQTYYRVS 184
            .|:..:...|...||:: |.|||| :.:.:.:::..|:|.|.||:.|..|.|..|.:..|||::|
  Fly   117 TIIHMNRTKFKTALLKY-LTALPAISVVTNVLKWSLGELKLRFRTNLTHHLYSQYLNGYTYYKMS 180

Mouse   185 NMDGRLRNPDQSLTEDVVAFAASVAHLYSNLTKPLLDVAVTSYTLLRAARSRGAGTAWPSAIAGL 249
            |:|.|:.|.||.||.|:..|..|...||||::||:||:.:..|.|     :...|...||.:...
  Fly   181 NLDNRIANADQLLTTDIDKFCESATDLYSNISKPVLDIFIYVYRL-----TVNLGGKTPSILMLY 240

Mouse   250 VVFLTANVLRAFSPKFGELVAEEARRKGELRYMHSRVVANSEEIAFYGGHEVELALLQHSYQDLA 314
            ::|....:.|...|. |.|..||.:.:||.||::||::.||||:|||.|:..|...|..||..|.
  Fly   241 LLFAGVFLTRLRRPT-GRLTVEEQKLEGEFRYVNSRLITNSEEVAFYQGNVREKLTLLASYSKLR 304

Mouse   315 SQINLILLERLWYVMLEQFLMKYVWSASGLLMVAVPIITATGYAESDSEAMKKAALEMKEEELVS 379
            |.:...|..|:...:::..:.||..|..|...|::|.     ::|:.         .:...|...
  Fly   305 SHLRKFLEFRVSMGIIDNIIGKYFASIVGFYAVSIPF-----FSENH---------PLLSGENSG 355

Mouse   380 ERTEAFTIARNLLTAAADATERIMSSYKEVTELAGYTARVYEMFQVFEDVKHCRFKRT----GDL 440
            :|.:|:.....:|...|:|..|::.:.:|::.|||:|||:.|:.:|..|:....::||    .:|
  Fly   356 QRLQAYYTYGRMLVKLAEAIGRLVLAGREMSRLAGFTARMTELIKVLSDLNKGTYERTMVNGNNL 420

Mouse   441 EEAQAGPGVMVQSGVHVEGPLKIQGQVVDVEQGIIC--------ENIPIITPTGEVVVASLNIRV 497
            .:...|      |.....||.|          ||:|        |.:|::||.|:|::..|:..|
  Fly   421 AQNAVG------SASSNFGPNK----------GIMCFEDNIIRFEKVPLVTPNGDVLLQELSFEV 469

Mouse   498 EEGMHLLITGPNGCGKSSLFRILGGLWPTYSGVLYKPPPQRMFYIPQRPYMSVGSLRDQVIYPDS 562
            :.|.::|:.|||||||||||||||.||||:.|.:.||...::||:||||||::|:||||:|||.:
  Fly   470 KSGTNVLVCGPNGCGKSSLFRILGELWPTWGGKVTKPSRGKLFYVPQRPYMTLGTLRDQIIYPHT 534

Mouse   563 AEDMRRKGCSEQQLEAILGIVHLRHILQREGGWEAVCDWKDVLSGGEKQRIGMARMFYHRPKYAL 627
            .:||||.|.|::.|...|.||.|.::.|||.|.:::.||.|||||||||||.|||:|||:|::|:
  Fly   535 RDDMRRLGHSDEDLMHYLDIVQLTYLEQRENGLDSIEDWIDVLSGGEKQRIAMARLFYHKPQFAI 599

Mouse   628 LDECTSAVSIDVEGKIFQAAKDAGIALLSITHRPSLWKYHTHLLQFDGEGGWKFEKLD 685
            |||||||||:|||||::...::.||.|.:::||.|||.:|.:.|||||.|.::|..:|
  Fly   600 LDECTSAVSVDVEGKMYSYCREVGITLFTVSHRKSLWAHHDYYLQFDGRGSYEFATID 657

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Abcd1	NP_031461.1	3a01203	1..681	CDD:273360	245/637 (38%)
		Interaction with PEX19. /evidence=ECO:0000250\|UniProtKB:P33897	67..186		40/119 (34%)
		PEX19 binding site and required for peroxisomal targeting. /evidence=ECO:0000250\|UniProtKB:P33897	67..84		7/16 (44%)
		ABC_membrane_2	83..352	CDD:284003	92/269 (34%)
		ABCD_peroxisomal_ALDP	474..679	CDD:213190	115/212 (54%)
		Required for homodimerization. /evidence=ECO:0000250\|UniProtKB:P33897	658..736		14/28 (50%)
Pmp70	NP_001259732.1	3a01203	3..653	CDD:273360	245/637 (38%)
		ABC_membrane_2	63..342	CDD:284003	99/290 (34%)
		ABCD_peroxisomal_ALDP	446..651	CDD:213190	113/204 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG4178
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG53776
OrthoDB	1	1.010	-	-		D146647at33208
OrthoFinder	1	1.000	-	-		FOG0000393
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100236
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3716
SonicParanoid	1	1.000	-	-		X313
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	7.760