DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Alppl2 and Alp6

DIOPT Version :9

Sequence 1:	NP_031459.3	Gene:	Alppl2 / 11650	MGIID:	108009	Length:	529	Species:	Mus musculus
Sequence 2:	NP_610496.1	Gene:	Alp6 / 35981	FlyBaseID:	FBgn0033423	Length:	515	Species:	Drosophila melanogaster

Alignment Length:	494	Identity:	205/494 - (41%)
Similarity:	277/494 - (56%)	Gaps:	48/494 - (9%)

- Green bases have known domain annotations that are detailed below.

Mouse    23 EEENPAFWNRKAAEAL--DAAKKLKPIQTSAKNLVILMGDGMGVSTVTATRILKGQQQGHLGPET 85
            ||:...:|..||...|  ..|::.......|||:::.:||||.|.||||||.|.|..      ..
  Fly    42 EEQQTQYWVDKAQAKLLSKLAEQESATTNKAKNVILFLGDGMSVHTVTATRNLLGDS------AE 100

Mouse    86 QLAMDRFPHMALSKTYNTDKQIPDSAGTGTAFLCGVKTNMKVIGLSAAARFNQCNTTWGNE--VV 148
            |:..:.||:..|||||..::|:.|||.|.||:|.|||.|...||::|......|:.....|  |:
  Fly   101 QVYFEGFPYTGLSKTYCVNRQVADSACTATAYLGGVKANYGTIGVNANVSRYSCDGAANEEDRVL 165

Mouse   149 SVMHRAKKAGKSVGVVTTTSVQHASPAGTYAHTVNRGWYSDAQM------PASALQDGCKDISTQ 207
            |:.|.|:.|||..|:|||..|.||||||.|||..:|.|.:|.::      |...:     ||:.|
  Fly   166 SIAHWAQAAGKDAGLVTTARVTHASPAGVYAHIADRNWENDWEVANRECDPEQTI-----DIARQ 225

Mouse   208 LIS---NMDIDVILGGGRKFMFPKGTPDQE-YPTDTKQAGTRLDGRNLVQEWLAKHQ----GARY 264
            |:.   ...:.||||||||........|:| ||      |.|.|||:|::.||.:.:    .|:|
  Fly   226 LVEQPVGQQLKVILGGGRKNFIDATVNDEEGYP------GKRTDGRHLIRSWLDQKKEANVSAKY 284

Mouse   265 VWNRSELIQASLNRSVTHLMGLFEPNDMKYEIHRDPAQ----DPSLAEMTEVAVRMLSRNPKGFY 325
            ||:|..|....| .:..:|:|||..:.:.|...||..:    ||||:|:||.|:.:||||.|||:
  Fly   285 VWSRKGLSLVDL-ENTDYLLGLFANDHLPYNGDRDRKRSQLADPSLSELTEAAITVLSRNDKGFF 348

Mouse   326 LFVEGGRIDHGHHETVAYRALTEAVMFDSAVDKADKLTSEQDTMILVTADHSHVFSFGGYTQRGA 390
            |||||.|||..||:|.|.|:|.:...|..||.||.:||||.||:|:|||||:||.|..||..|..
  Fly   349 LFVEGARIDMAHHDTFAKRSLEDTAEFARAVQKARELTSEDDTLIVVTADHAHVMSINGYPYRDQ 413

Mouse   391 SIFGLAPFKAEDGKSFTSILYGNGPGYKLHNG-----ARADVTEEESSNPTYQQQAAVPLSSETH 450
            .|.|||.. |:|...:|.:.|.|||||  ::|     .||.:.|:..::..||.....||.:|||
  Fly   414 EITGLAQL-ADDNLPYTILSYANGPGY--YSGYNRAEGRALLKEKLVADSDYQYPTLAPLDAETH 475

Mouse   451 SGEDVAIFARGPQAHLVHGVQEQNYIAHVMAFAACLEPY 489
            .|:|||::|.||.|....|..||:.|..:||.||.:.||
  Fly   476 GGDDVAVYASGPYAQYFSGNYEQSNIPALMARAAGIGPY 514

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alppl2	NP_031459.3	Alk_phosphatase	51..486	CDD:333956	196/459 (43%)
Alp6	NP_610496.1	ALP_like	72..511	CDD:304875	196/459 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167847862
Domainoid	1	1.000	373	1.000	Domainoid score	I882
eggNOG	1	0.900	-	-		E1_COG1785
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	386	1.000	Inparanoid score	I2003
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG48882
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		mtm8682
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.900