Protein Alignment RAB39B and Rab4

DIOPT Version :10

• Sequence 1: NP_741995.1
• Gene: RAB39B / 116442
• HGNCID: 16499
• Length: 213
• Species: Homo sapiens
• Sequence 2: NP_523777.1
• Gene: Rab4 / 36992
• FlyBaseID: FBgn0016701
• Length: 213
• Species: Drosophila melanogaster
• Alignment Length: 215
• Identity: 86/215 - (40%)
• Similarity: 127/215 - (59%)
• Gaps: 6/215 - (2%)

Human     1 MEAIWLYQFRLIVIGDSTVGKSCLIRRFTEGRFAQVSDPTVGVDFFSRLVEIEPGKRIKLQIWDT 65
            |...:.|.|:.::||.:..|||||:..|.|.:|...|..|:||:|.||:|.: .||.:|||||||
  Fly     1 MSETYDYLFKFLIIGSAGSGKSCLLHHFIESKFKDDSSHTIGVEFGSRIVNV-GGKSVKLQIWDT 64

Human    66 AGQERFRSITRAYYRNSVGGLLLFDITNRRSFQNVHEWLEETKVHVQPYQIVFVLVGHKCDLDTQ 130
            ||||||||:||:|||.:.|.||::|.|:|.||..:..||.:.:....| .||.:|||:|.||:..
  Fly    65 AGQERFRSVTRSYYRGAAGALLVYDATSRDSFNALTNWLNDARTLASP-NIVILLVGNKKDLEEA 128

Human   131 RQVTRHEAEKLAAAYGMKYIETSARDAINVEKAFTDLTRDIYELVKRGEITIQEGWEGVKSG--F 193
            |.||..||...|....:.::||||:...|||:||...::.|...::.||:..:....|::.|  .
  Fly   129 RDVTFLEASTFAQENELIFLETSAKTGENVEEAFLKCSKTILAKIETGELDPERIGSGIQYGGAA 193

Human   194 VPNVVHSSEEVVKSERRCLC 213
            :.|:......:.|.:  |.|
  Fly   194 LRNLQTRQRSINKPD--CTC 211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB39B	NP_741995.1	Rab39	7..213	CDD:133311	84/207 (41%)
		Switch-I. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	35..43		2/7 (29%)
		Switch-II. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	67..83		12/15 (80%)
Rab4	NP_523777.1	Rab4	9..169	CDD:206696	75/161 (47%)