Protein Alignment RAB39B and Rab27

DIOPT Version :10

• Sequence 1: NP_741995.1
• Gene: RAB39B / 116442
• HGNCID: 16499
• Length: 213
• Species: Homo sapiens
• Sequence 2: NP_726743.1
• Gene: Rab27 / 31103
• FlyBaseID: FBgn0025382
• Length: 236
• Species: Drosophila melanogaster
• Alignment Length: 215
• Identity: 83/215 - (38%)
• Similarity: 122/215 - (56%)
• Gaps: 13/215 - (6%)

Human    10 RLIVIGDSTVGKSCLIRRFTEGRFAQVSDPTVGVDF-FSRLVEIEPGK--RIKLQIWDTAGQERF 71
            :.:|:|||.|||:||:.::|:|||......|||:|| ..||:....|:  ||.||||||||||||
  Fly    19 QFLVLGDSGVGKTCLLYQYTDGRFHTQFISTVGIDFREKRLLYNSRGRRHRIHLQIWDTAGQERF 83

Human    72 RSITRAYYRNSVGGLLLFDITNRRSFQNVHEWLEETKVHVQPYQIVFVLVGHKCDLDTQRQVTRH 136
            ||:|.|:||:::|.||:||:|:.:||.....||.:.:.|........||.|:||||...|.|:|.
  Fly    84 RSLTTAFYRDAMGFLLIFDLTSEKSFLETANWLSQLRTHAYSEDPDVVLCGNKCDLLQLRVVSRD 148

Human   137 EAEKLAAAYGMKYIETSARDAINVEKAFTDLTRDIYELVKRGEITIQEGWEGVKSGFVPNVVHSS 201
            :...|...|.:.||||||....||::|...|...:.|.::......:......:|..:||:.:..
  Fly   149 QVAALCRRYRLPYIETSACTGANVKEAVELLVGRVMERIENAACNREFSLLLTQSRCLPNIAYGQ 213

Human   202 -EEVVK---------SERRC 211
             |::|:         |.|.|
  Fly   214 PEDLVRLHDRREEPCSRRNC 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
RAB39B	NP_741995.1	Rab39	7..213	CDD:133311	83/215 (39%)
		Switch-I. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	35..43		2/7 (29%)
		Switch-II. /evidence=ECO:0000255|PROSITE-ProRule:PRU00753	67..83		11/15 (73%)
Rab27	NP_726743.1	P-loop containing Nucleoside Triphosphate Hydrolases	19..187	CDD:476819	75/167 (45%)