DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ahrr and ss

DIOPT Version :9

Sequence 1:	NP_033774.1	Gene:	Ahrr / 11624	MGIID:	1333776	Length:	701	Species:	Mus musculus
Sequence 2:	NP_001163629.2	Gene:	ss / 41988	FlyBaseID:	FBgn0003513	Length:	1015	Species:	Drosophila melanogaster

Alignment Length:	737	Identity:	208/737 - (28%)
Similarity:	303/737 - (41%)	Gaps:	219/737 - (29%)

- Green bases have known domain annotations that are detailed below.

Mouse    10 YAGRKRR------KPIQKRRLTMGAEKSNPSKRHRDRLNTELDHLASLLPFSPDIISKLDKLSVL 68
            ||.::||      ||..|.    |..|||||||||:|||.|||.|||||||..:|:||||:||:|
  Fly     8 YATKRRRRNGKSLKPPPKD----GVTKSNPSKRHRERLNAELDLLASLLPFEQNILSKLDRLSIL 68

Mouse    69 RLSVSYLRVKSFFQALQETCVWSAPALSPEEHSYRGFPVQE----------GRLLLESLNGFALV 123
            ||||||||.||:||.:..........| |..|::.|:..:|          |.:.|::||||.::
  Fly    69 RLSVSYLRTKSYFQVVMHKDKEDNGVL-PHIHAHDGYRTRELGAFEHGLLDGDMFLQALNGFLMI 132

Mouse   124 VSAEGMIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQSPHADT 188
            ::.||.:|:|:.:|..||||||:|::||::|:.:|.:||::..|||.|
  Fly   133 LTCEGEVFFATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQLLW----------------- 180

Mouse   189 DNTVLGKLLRAQEGGKGLPSEYSAFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKTPS 253
             |:.|...:.:.:..:.|..:.:.:|.|.|..|.|||||:|||||.:..:|::|.|.||.:||..
  Fly   181 -NSFLPADMSSMQLAETLAPDKALYLERSFTVRFRCLLDNTSGFLRLDIRGRIKVLHGQNRKTEE 244

Mouse   254 GTALPPRLSLFCIVAPV-LPSVTEMKMKSTFLKAKHRADI-VVTMDSRAKAVTSLCESEL----- 311
                 |.|:||....|. .||:.|:..|....|:||:.|. :|:||.|.|.:....::||
  Fly   245 -----PPLALFAYCTPFGPPSLLEIPHKENMFKSKHKLDFSLVSMDQRGKHILGYADAELVNMGG 304

Mouse   312 -----HPKLNYLAGK-----SNGENGISLFRGQTDRSHWARALARSSCLCLRGGPD--------L 358
                 :..|.|:|..     ..|.:|:..:|.|.....|......|..:.....||        |
  Fly   305 YDLVHYDDLAYVASAHQELLKTGASGMIAYRYQKKDGEWQWLQTSSRLVYKNSKPDFVICTHRQL 369

Mouse   359 LDPKGTS--GDR------------------EEEDQKHI-LRRSPGAWGQREMHKYSYGLETPVHL 402
            :|.:|..  |.|                  .|.||..: ...||.|          :.|..||..
  Fly   370 MDEEGHDLLGKRTMDFKVSYLDTGLASTYFSEADQLVVPPSTSPTA----------HALPPPVTP 424

Mouse   403 RHLN--WSTEQRSQESTTKLTRQ-PSKNEPSTCLVPH-----GSCVP-----------------Y 442
            ...|  :.|:.|...||.:..|: ..:|:|.|.....     ||..|                 |
  Fly   425 TRPNRRYKTQLRDFLSTCRSKRKLQQQNQPQTQQTSPLGGQVGSPAPAVAVEYLPDPAAAVAAAY 489

Mouse   443 PGSQGMLSASNMASFRDSL----DHPTGAYCSQMNRPLSD--IHQGQVDPSTCHISQGSLG---S 498
            .....|.:.|..||..|:|    ..|..|:     .|:|:  .||.::        ||::|   :
  Fly   490 SNLNPMYTTSPYASAADNLYMGSSMPANAF-----YPVSENLFHQYRL--------QGAVGGYYT 541

Mouse   499 RIPLTG--MQRFTARGFSTEDAKLPSLPVTIGTPCNPVLSLDVPIKMENESGSQDIVEASTTSCL 561
            ..|.:|  ...:.|.||.:.|.                                 ...||.....
  Fly   542 DYPHSGAPASAYVANGFLSYDG---------------------------------YAIASKADEK 573

Mouse   562 WLGTSDMARGHLVGF------PARMHLKTEPDYRQQ----AC-----------TPHLGHGML--- 602
            |..|.....|:..|:      |.::.|||.....|.    :|           ||: |.|.:
  Fly   574 WQETGKYYSGYSSGYGSPTSTPQQIPLKTPKSSPQVMEVISCSSDGPSPVGGATPN-GVGSVTPK 637

Mouse   603 ------------GTNPYSRDTV 612
                        |.:||.|.||
  Fly   638 VELAGTTAAAAAGQDPYERQTV 659

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ahrr	NP_033774.1	HLH	35..86	CDD:197674	37/50 (74%)
		PAS	108..174	CDD:214512	29/75 (39%)
		PAS	108..>173	CDD:279347	29/74 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	409..432		7/23 (30%)
		Needed for transcriptional repression	555..701		22/94 (23%)
ss	NP_001163629.2	HLH	35..76	CDD:197674	31/40 (78%)
		PAS	123..178	CDD:214512	24/54 (44%)
		PAS_3	282..366	CDD:285623	18/83 (22%)
		PAS	<291..369	CDD:238075	13/77 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167837321
Domainoid	1	1.000	86	1.000	Domainoid score	I8087
eggNOG	1	0.900	-	-		E1_KOG3560
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10649
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5400
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.830