Protein Alignment Ahrr and ss

DIOPT Version :10

• Sequence 1: NP_033774.1
• Gene: Ahrr / 11624
• MGIID: 1333776
• Length: 701
• Species: Mus musculus
• Sequence 2: NP_001163629.2
• Gene: ss / 41988
• FlyBaseID: FBgn0003513
• Length: 1015
• Species: Drosophila melanogaster
• Alignment Length: 737
• Identity: 208/737 - (28%)
• Similarity: 303/737 - (41%)
• Gaps: 219/737 - (29%)

Mouse    10 YAGRKRR------KPIQKRRLTMGAEKSNPSKRHRDRLNTELDHLASLLPFSPDIISKLDKLSVL 68
            ||.::||      ||..|.    |..|||||||||:|||.|||.|||||||..:|:||||:||:|
  Fly     8 YATKRRRRNGKSLKPPPKD----GVTKSNPSKRHRERLNAELDLLASLLPFEQNILSKLDRLSIL 68

Mouse    69 RLSVSYLRVKSFFQALQETCVWSAPALSPEEHSYRGFPVQE----------GRLLLESLNGFALV 123
            ||||||||.||:||.:..........| |..|::.|:..:|          |.:.|::||||.::
  Fly    69 RLSVSYLRTKSYFQVVMHKDKEDNGVL-PHIHAHDGYRTRELGAFEHGLLDGDMFLQALNGFLMI 132

Mouse   124 VSAEGMIFYASATIVDYLGFHQTDVMHQNIYDYIHVDDRQDFCRQLHWAMDPPQVVFGQSPHADT 188
            ::.||.:|:|:.:|..||||||:|::||::|:.:|.:||::..|||.|
  Fly   133 LTCEGEVFFATHSIESYLGFHQSDIVHQSVYELVHSEDREELQRQLLW----------------- 180

Mouse   189 DNTVLGKLLRAQEGGKGLPSEYSAFLTRCFICRVRCLLDSTSGFLTMQFQGKLKFLFGQKKKTPS 253
             |:.|...:.:.:..:.|..:.:.:|.|.|..|.|||||:|||||.:..:|::|.|.||.:||..
  Fly   181 -NSFLPADMSSMQLAETLAPDKALYLERSFTVRFRCLLDNTSGFLRLDIRGRIKVLHGQNRKTEE 244

Mouse   254 GTALPPRLSLFCIVAPV-LPSVTEMKMKSTFLKAKHRADI-VVTMDSRAKAVTSLCESEL----- 311
                 |.|:||....|. .||:.|:..|....|:||:.|. :|:||.|.|.:....::||
  Fly   245 -----PPLALFAYCTPFGPPSLLEIPHKENMFKSKHKLDFSLVSMDQRGKHILGYADAELVNMGG 304

Mouse   312 -----HPKLNYLAGK-----SNGENGISLFRGQTDRSHWARALARSSCLCLRGGPD--------L 358
                 :..|.|:|..     ..|.:|:..:|.|.....|......|..:.....||        |
  Fly   305 YDLVHYDDLAYVASAHQELLKTGASGMIAYRYQKKDGEWQWLQTSSRLVYKNSKPDFVICTHRQL 369

Mouse   359 LDPKGTS--GDR------------------EEEDQKHI-LRRSPGAWGQREMHKYSYGLETPVHL 402
            :|.:|..  |.|                  .|.||..: ...||.|          :.|..||..
  Fly   370 MDEEGHDLLGKRTMDFKVSYLDTGLASTYFSEADQLVVPPSTSPTA----------HALPPPVTP 424

Mouse   403 RHLN--WSTEQRSQESTTKLTRQ-PSKNEPSTCLVPH-----GSCVP-----------------Y 442
            ...|  :.|:.|...||.:..|: ..:|:|.|.....     ||..|                 |
  Fly   425 TRPNRRYKTQLRDFLSTCRSKRKLQQQNQPQTQQTSPLGGQVGSPAPAVAVEYLPDPAAAVAAAY 489

Mouse   443 PGSQGMLSASNMASFRDSL----DHPTGAYCSQMNRPLSD--IHQGQVDPSTCHISQGSLG---S 498
            .....|.:.|..||..|:|    ..|..|:     .|:|:  .||.::        ||::|   :
  Fly   490 SNLNPMYTTSPYASAADNLYMGSSMPANAF-----YPVSENLFHQYRL--------QGAVGGYYT 541

Mouse   499 RIPLTG--MQRFTARGFSTEDAKLPSLPVTIGTPCNPVLSLDVPIKMENESGSQDIVEASTTSCL 561
            ..|.:|  ...:.|.||.:.|.                                 ...||.....
  Fly   542 DYPHSGAPASAYVANGFLSYDG---------------------------------YAIASKADEK 573

Mouse   562 WLGTSDMARGHLVGF------PARMHLKTEPDYRQQ----AC-----------TPHLGHGML--- 602
            |..|.....|:..|:      |.::.|||.....|.    :|           ||: |.|.:
  Fly   574 WQETGKYYSGYSSGYGSPTSTPQQIPLKTPKSSPQVMEVISCSSDGPSPVGGATPN-GVGSVTPK 637

Mouse   603 ------------GTNPYSRDTV 612
                        |.:||.|.||
  Fly   638 VELAGTTAAAAAGQDPYERQTV 659

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ahrr	NP_033774.1	bHLH-PAS_AhRR	27..86	CDD:381441	43/58 (74%)
		PAS	108..174	CDD:214512	29/75 (39%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	409..432		7/23 (30%)
		Needed for transcriptional repression	555..701		22/94 (23%)
ss	NP_001163629.2	bHLH-PAS_spineless_like	24..87	CDD:381573	44/66 (67%)
		PAS	123..178	CDD:214512	24/54 (44%)
		PAS_3	282..366	CDD:430001	18/83 (22%)