DRSC/TRiP Functional Genomics Resources

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Protein Alignment Ahr and sim

DIOPT Version :10

Sequence 1:NP_038492.1 Gene:Ahr / 11622 MGIID:105043 Length:805 Species:Mus musculus
Sequence 2:NP_524340.2 Gene:sim / 41612 FlyBaseID:FBgn0004666 Length:688 Species:Drosophila melanogaster


Alignment Length:705 Identity:178/705 - (25%)
Similarity:275/705 - (39%) Gaps:175/705 - (24%)


- Green bases have known domain annotations that are detailed below.


Mouse    33 NPSKRHRDRLNTELDRLASLLPFPQDVINKLDKLSVLRLSVSYLRAKSFFDVAL----KSTPADR 93
            |.::..|::.|||...||.|||.|..:.::|||.||:||:.|||:.:..|...|    .|:||.:
  Fly    31 NAARTRREKENTEFCELAKLLPLPAAITSQLDKASVIRLTTSYLKMRQVFPDGLGEAWGSSPAMQ 95

Mouse    94 NGGQDQCRAQIRDWQDLQEGEFLLQALNGFVLVVTADALVFYASSTIQDYLGFQQSDVIHQSVYE 158
            .|      |.|::.     |..|||.|:||:.||..|..:.|.|.|...:||..|.::...|::|
  Fly    96 RG------ATIKEL-----GSHLLQTLDGFIFVVAPDGKIMYISETASVHLGLSQVELTGNSIFE 149

Mouse   159 LIHTEDRAEFQR--QLHWALNPDSAQGVDEAHGPPQAAVYYTPDQLPPENASF---MERCFRCRL 218
            .||..|:.|...  .||..:|...........|.|....:  |.....:..|.   :|:.|..|:
  Fly   150 YIHNYDQDEMNAILSLHPHINQHPLAQTHTPIGSPNGVQH--PSAYDHDRGSHTIEIEKTFFLRM 212

Mouse   219 RCLLD------NSSGFLAMNFQGRLKYLHGQNKKGKDGALLPPQLALFAIATPLQPPSILEIRTK 277
            :|:|.      .:|||..::..|.||.....::....|:|: ..|.|.|:...|...:|.||:..
  Fly   213 KCVLAKRNAGLTTSGFKVIHCSGYLKARIYPDRGDGQGSLI-QNLGLVAVGHSLPSSAITEIKLH 276

Mouse   278 NFIFRTKHKLDFTPIGCDAKGQLILGYTEVELCTRGSGYQFIHAADILHCAESHIRMIKTGESGM 342
            ..:|..:.|||...|..||:...:.||...:|..: :.||:||||||:....||..::..|:...
  Fly   277 QNMFMFRAKLDMKLIFFDARVSQLTGYEPQDLIEK-TLYQYIHAADIMAMRCSHQILLYKGQVTT 340

Mouse   343 TVFRLLAKHSRWRWVQSNARLIY--RNGRPDYIIATQRPLTDEEGRE----HLQ----KRSTSLP 397
            ..:|.|.|...|.||||.|.|::  |:.|..:|::....|::.|.::    .:|    ||....|
  Fly   341 KYYRFLTKGGGWVWVQSYATLVHNSRSSREVFIVSVNYVLSEREVKDLVLNEIQTGVVKREPISP 405

Mouse   398 ----------------------------------------------FMFATGEAV---------- 406
                                                          ...|||:.|          
  Fly   406 AAQAAQAAQAAQAAQAAQAAQAAHVAQAVQAQVVVVPQQSVVVQPQCAGATGQPVGPGTPVSLAL 470

Mouse   407 --------LYEISSPFSPIMDPLPIRTKSNTSRKDWAPQSTPSKDSFH----PSSLMSALIQQDE 459
                    .:|...|..|.:.|:|....|::|       |..:...:|    .....|..:..|.
  Fly   471 SASPKLDPYFEPELPLQPAVTPVPPTNNSSSS-------SNNNNGVWHHHHVQQQQQSGSMDHDS 528

Mouse   460 SIY--LCPPSSPALLDSHFLMGSVSKCGSWQDSFAAAGSEAALKHEQIGHAQDVNLALSGG--PS 520
            ..|  |.||.      :..::.|.|..|....|.|..||.|:              |.|.|  .:
  Fly   529 LSYTQLYPPL------NDLVVSSSSSVGGGTASSAGGGSSAS--------------ASSSGVYST 573

Mouse   521 EL-FPD--------NKNNDLY-----------SIMRNLGIDFEDI-RSMQNEEFFRT------DS 558
            |: :||        |.||..|           |::|....:.... .|.::|....|      :.
  Fly   574 EMQYPDTTTGNLYYNNNNHYYYDYDATVDVATSMIRPFSANSNSCSSSSESERQLSTGNASIVNE 638

Mouse   559 TAAGEVDFKDIDITDEILTYVQDSLNNSTLLNSACQQQPVTQHLSCMLQERLQLE 613
            |:..:..:.|:....| |:|..|   ||:..:...|||   |||  |.|:.||.:
  Fly   639 TSPSQTTYSDLSHNFE-LSYFSD---NSSQQHQHQQQQ---QHL--MEQQHLQYQ 684

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AhrNP_038492.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..38 1/4 (25%)
Nuclear localization signal 1. /evidence=ECO:0000250|UniProtKB:P35869 12..15
bHLH-PAS_AhR 27..87 CDD:381442 23/57 (40%)
Nuclear localization signal 2. /evidence=ECO:0000250|UniProtKB:P35869 36..41 1/4 (25%)
DNA-binding. /evidence=ECO:0000250|UniProtKB:P35869 37..65 11/27 (41%)
Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P35869 49..81 16/31 (52%)
Nuclear export signal. /evidence=ECO:0000250|UniProtKB:P35869 63..71 5/7 (71%)
PAS 111..>177 CDD:395786 24/67 (36%)
Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561 116..124 5/7 (71%)
Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561 260..262 0/1 (0%)
PAS_3 291..376 CDD:430001 30/86 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 421..449 5/31 (16%)
simNP_524340.2 bHLH-PAS_dSIM_like 25..86 CDD:381583 23/54 (43%)
PAS 102..215 CDD:395786 32/119 (27%)
PAS_3 291..377 CDD:430001 30/86 (35%)
Blue background indicates that the domain is not in the aligned region.

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