Protein Alignment Ahr and tgo

DIOPT Version :10

• Sequence 1: NP_038492.1
• Gene: Ahr / 11622
• MGIID: 105043
• Length: 805
• Species: Mus musculus
• Sequence 2: NP_731308.1
• Gene: tgo / 41084
• FlyBaseID: FBgn0264075
• Length: 642
• Species: Drosophila melanogaster
• Alignment Length: 809
• Identity: 170/809 - (21%)
• Similarity: 281/809 - (34%)
• Gaps: 268/809 - (33%)

Mouse     5 ANI----TYASRKRRKPVQKTVKPIPAEGIKSNPSKRHRDRLNTELDRLASLLPFPQDVINKLDK 65
            |||    .:|||:....::                :|.|:::...:..|:.::|....:..|.||
  Fly     4 ANIQDKERFASRENHCEIE----------------RRRRNKMTAYITELSDMVPTCSALARKPDK 52

Mouse    66 LSVLRLSVSYLRAKSFFDVALKSTPADRNGGQDQCRAQIRDWQDLQEGEFLLQALNGFVLVVTAD 130
            |::||::|::::       ||:.|....:.|  ..:......|:|:  ..:|:|.:||:.||:.|
  Fly    53 LTILRMAVAHMK-------ALRGTGNTSSDG--TYKPSFLTDQELK--HLILEAADGFLFVVSCD 106

Mouse   131 A-LVFYASSTIQDYLGFQQSDVIHQSVYELIHTEDRAEFQRQLHWALNPDSAQGVDEAHGPPQAA 194
            : .|.|.|.::...|.:.|||....|:||.||.:||.:.:.||....:.::.:.:|...|..:..
  Fly   107 SGRVIYVSDSVTPVLNYTQSDWYGTSLYEHIHPDDREKIREQLSTQESQNAGRILDLKSGTVKKE 171

Mouse   195 VYYTPDQLPPENASFMERCFRCRLRCLLDNSSGFLAMNFQGRLKYLHGQNKKG--KDG---ALL- 253
            .:.:..:|    :....|.|.||:|....|....::    |.|..|..:|..|  :||   |::
  Fly   172 GHQSSMRL----SMGARRGFICRMRVGNVNPESMVS----GHLNRLKQRNSLGPSRDGTNYAVVH 228

Mouse   254 --------PP------------------QLALFAIATPLQPPSI----LEIRTKNFIFRTKHKLD 288
                    ||                  ...|.||.. ||..|.    :........|.|:|.:|
  Fly   229 CTGYIKNWPPTDMFPNMHMERDVDDMSSHCCLVAIGR-LQVTSTAANDMSGSNNQSEFITRHAMD 292

Mouse   289 --FTPIGCDAKGQLILGYTEVEL----CTRGSGYQFIHAADILHCAESHIRMIK-TGESGMTVFR 346
              ||.:  |.:...|||||..||    |     |.|.|..|..|..||..:::| .|:....::|
  Fly   293 GKFTFV--DQRVLNILGYTPTELLGKIC-----YDFFHPEDQSHMKESFDQVLKQKGQMFSLLYR 350

Mouse   347 LLAKHSRWRWVQSNARLIYRNGRPDYIIATQRPLTDEEGREHLQKRSTSLPFMFATGEAVLYEIS 411
            ..||:|.:.|:::.|            .|...|.|||            :.::..|..:
  Fly   351 ARAKNSEYVWLRTQA------------YAFLNPYTDE------------VEYIVCTNSS------ 385

Mouse   412 SPFSPIMDPLPIRTKSNTSRKDWAPQSTPSKDSFHPSSLMSALIQQDESIYL-CPPSSPALLDSH 475
               ...|...|:         |.|...||.:        :....||::.:|: ..|.........
  Fly   386 ---GKTMHGAPL---------DAAAAHTPEQ--------VQQQQQQEQHVYVQAAPGVDYARREL 430

Mouse   476 FLMGSVSKCGSWQDSFAAAGSEAALKHEQ------------IGHAQDVNLA--LSGGPSELFPDN 526
            ..:||.:..|.:|....|..:....:.:|            :|:..|...:  .:||||.|
  Fly   431 TPVGSATNDGMYQTHMLAMQAPTPQQQQQQQQRPGSAQTTPVGYTYDTTHSPYSAGGPSPL---- 491

Mouse   527 KNNDLYSIMRNLGIDFEDIRSMQNEEFFRTDSTAAGEVDFKDIDITDEILTYVQDSLNNSTLLNS 591
                                                                       :.:..|
  Fly   492 -----------------------------------------------------------AKIPKS 497

Mouse   592 ACQQQPVTQHLSCMLQERLQLEQQQQLQQPPPQALEPQQQLCQMVCP-QQDLGPKHTQIN----- 650
            .....||..:....|:.    :||||.|||..:..:.||     ..| :...||.:||::
  Fly   498 GTSPTPVAPNSWAALRP----QQQQQQQQPVTEGYQYQQ-----TSPARSPSGPTYTQLSAGNGN 553

Mouse   651 ------GTFASWNPTPPVSFNCP-----QQELKHYQLFSSLQGTAQEFPYKPEVDSVPYTQNFAP 704
                  |.:.:..|.||   |.|     ||...|              |:.|...:.|:..:..|
  Fly   554 RQQAQPGAYQAGPPPPP---NAPGMWDWQQAGGH--------------PHPPHPTAHPHHPHAHP 601

Mouse   705 -----CNQPLLPEHSKSVQ-LDFPGRDFE 727
                 ..||...|.|..:| ||.....||
  Fly   602 GGPAGAGQPQGQEFSDMLQMLDHTPTTFE 630

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ahr	NP_038492.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..38		6/36 (17%)
		Nuclear localization signal 1. /evidence=ECO:0000250|UniProtKB:P35869	12..15		1/2 (50%)
		bHLH-PAS_AhR	27..87	CDD:381442	12/59 (20%)
		Nuclear localization signal 2. /evidence=ECO:0000250|UniProtKB:P35869	36..41		2/4 (50%)
		DNA-binding. /evidence=ECO:0000250|UniProtKB:P35869	37..65		5/27 (19%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P35869	49..81		9/31 (29%)
		Nuclear export signal. /evidence=ECO:0000250|UniProtKB:P35869	63..71		4/7 (57%)
		PAS	111..>177	CDD:395786	23/66 (35%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561	116..124		3/7 (43%)
		Required for maintaining the overall integrity of the AHR:ARNT heterodimer and its transcriptional activity. /evidence=ECO:0000250|UniProtKB:P30561	260..262		0/1 (0%)
		PAS_3	291..376	CDD:430001	24/89 (27%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	421..449		5/27 (19%)
tgo	NP_731308.1	bHLH-PAS_ARNT	9..74	CDD:381517	17/87 (20%)
		PAS	90..154	CDD:214512	23/63 (37%)
		PAS_11	282..384	CDD:464214	36/132 (27%)