DRSC/TRiP Functional Genomics Resources

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Protein Alignment Agrn and wb

DIOPT Version :9

Sequence 1:XP_006538554.1 Gene:Agrn / 11603 MGIID:87961 Length:2057 Species:Mus musculus
Sequence 2:NP_723870.1 Gene:wb / 43946 FlyBaseID:FBgn0261563 Length:3375 Species:Drosophila melanogaster


Alignment Length:2205 Identity:434/2205 - (19%)
Similarity:651/2205 - (29%) Gaps:892/2205 - (40%)


- Green bases have known domain annotations that are detailed below.


Mouse   152 EFCVEDKPGIHFTAAPSMPPDVCR-------GMLC-----GFGAVCEPSVEDPGRASCV-CKKNV 203
            |.|..|         |.:...:|:       |:.|     ||....:..:.||    |: |..| 
  Fly   459 ESCTYD---------PFLDKGICQSCSNNTAGIECEFCEMGFYRELDAPLTDP----CLPCSCN- 509

Mouse   204 CPAMVAPVCGSDAST-------------------YSNECELQRAQCNQQRRIRLLRQGPCGSRDP 249
             ||.....|.||..:                   |.::|  :|.:|::        :|..||...
  Fly   510 -PARSTGGCQSDGGSCNCLEGFQGKNCEECAPGYYGDDC--KRCECDE--------RGSLGSTGS 563

Mouse   250 CANV-TCSF---GSTC-----------VPSADGQTASCLC---PTTCFGAPDGTVCGSDGVDY-- 294
            |:.| .|..   ||||           ..:|:|.| ||.|   ..||..|...|:......|:  
  Fly   564 CSGVCQCKLNVEGSTCSECAPGYFDLSAENAEGCT-SCWCSGVSQTCHSAKLQTLAFETLNDWKI 627

Mouse   295 -----------PSECQLLRHACANQ----EHIFKKFDGPCDPCQGSMSDL-NHICRVNPR----- 338
                       |.:.:..|...||:    |.|:         .|.|:..| |.:.....|     
  Fly   628 TDIQRVKPISIPVDAETNRLIFANELDEVEAIY---------WQASLGYLGNRLTSYGSRLQLVL 683

Mouse   339 -------------TRHPEMLLRPENCPAQHTPIC-GD---DGVTYENDCVMSRIG---AARGLLL 383
                         |..|.::|..:|    ...|. ||   ||:....:..::.:|   ....::.
  Fly   684 SWDVIRGDRSGKPTTGPNVILVGKN----GLKIAFGDESLDGLGINLNVTLTEVGWYHVPPTVVD 744

Mouse   384 QKVRSGQCQTRDQCPET---CQFNSVCLSRRGRPHCSCDRVTCDGAY----------RPVCAQDG 435
            .|.|..:.:..|...|:   .||.||.:        |.|.|....|:          |.|....|
  Fly   745 IKTRLRRTEGGDYHGESVTRSQFLSVLV--------SLDAVLIRAAFHTDQGETSLERAVIYSGG 801

Mouse   436 HTYDNDCWRQQAECRQQQTIPPKHQGPCDQTPSPCRGAQCAFGATCTVKN-------GKAV-CEC 492
            .........|..:|          ..|...|...|.|  ||||.....:|       .|.: |.|
  Fly   802 VELGGKSSSQVEQC----------LCPAGYTGLSCEG--CAFGFKRIYENTSDHQILSKCIPCPC 854

Mouse   493 QRVCSGGYDPVCGSDGVTYGSVCELESMACTLGREIRVARRGPC------DRCGQCRFGSLCEVE 551
            .                .:.:.|:|:|..|           |.|      |||.:|:.|......
  Fly   855 N----------------GHSNSCDLQSGNC-----------GDCMHNTFGDRCERCQLGYYGNPL 892

Mouse   552 TG------RCVCP-SECVESAQPVCGSDGHTYAS---ECELHVHA---CTHQISLYVASAGHCQT 603
            .|      ||.|| ||...:..|.|....:.|..   :.||..||   ||.....|  :..|||.
  Fly   893 QGTPNDCKRCACPLSEDSNNFSPSCQLKSYNYMDLNPQFELIEHAEYICTQCPEGY--TGDHCQV 955

Mouse   604 CGETVCTFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYLSACELREAAC------QQQVQIEEAR 662
            |.:..  ||.....|.. |.||:       |..      ..|.:....|      .:....|..:
  Fly   956 CDDGY--FGNPRQPGSS-CQRCD-------CAG------GPCNVTTGECITCRGNTEGWHCERCK 1004

Mouse   663 AG-------PCEPAECGSGGSGSGEDNACEQELCRQHGGVWDEDSEDGPCV------------CD 708
            .|       .|:|..|.:.||.||        ||         ||.||.|:            ||
  Fly  1005 LGYWGDPAVGCDPCHCHTEGSESG--------LC---------DSTDGQCLCKPRYAGQKCDECD 1052

Mouse   709 FSCQSV-LKSPVCGSDGV---------TYSTECHLKK----ARCEARQELYVAAQG-ACRGPTLA 758
            ....:| |:.|.|..|.:         .::.:||.|:    |:|...|:.|..... |.|...||
  Fly  1053 VGYANVELRCPSCNCDPLGSLVQDRCDPHTGQCHCKEGVMGAKCHECQDGYFGMNAVAYRMDDLA 1117

Mouse   759 -------------PLLPMASPHCAQTPYGCCQDNVTAAQGVGLAGCPSTCHCNPHGSYSGTCDPV 810
                         .|:|......:::...|                 ..|||:..||.|..||..
  Fly  1118 ALRQNSDSDDDEWELVPDTEDPNSESTVAC-----------------EECHCSSVGSLSSDCDKR 1165

Mouse   811 TGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGHSGCTPCSCDPRGAVRDDCEQMTGLCSCRPGVA 875
            ||||:|...|.|.|||:|.||.||    :|.| .||..|.|||.|:...:|...||.|.|:.||.
  Fly  1166 TGQCACLANVTGRRCDKCRPGHWN----LTAG-EGCRDCRCDPHGSRGHECNPWTGQCDCKIGVG 1225

Mouse   876 GPKCGQCPDG---------------QALGH-----------------LGC-EADPTT-----PVT 902
            |..|.:|.:|               ::.|.                 ||| :..|.|     .:.
  Fly  1226 GQHCNECTEGFFGFSTEGCQRCSACRSEGQVCDPHNGRCICPKFTRGLGCGQCVPGTWGWQARLG 1290

Mouse   903 CVEMHCE----FGASCVEEAGFAQCVC-------PTLTC-------PE--------------ANS 935
            |.|..|:    .|..|  ..|..||.|       ...||       ||              |:.
  Fly  1291 CRECECDHIGSIGQQC--STGDGQCQCREGYSGRKCDTCAIGYFGYPECRRCGCDAEGSFTQADG 1353

Mouse   936 TKVCGSDGVTYGNECQLKTIACRQRLDISIQSL--------------------GPCRESVAPGVS 980
            :..|.|:|     :|..|::....:.|..:||.                    |.|.:|   .:|
  Fly  1354 SIACDSNG-----QCPCKSLVVGLKCDTCMQSTFGLSAQNPEGCTRCFCFGRSGECEQS---DLS 1410

Mouse   981 PTSASMTTPRHILSRTLASPHSSLPLSPSTTAHDWPTPLPTSPQTVVGTPRSTAATPSDVASLAT 1045
            .....|...|: ||.....|||                :|:|....:                  
  Fly  1411 WGHIRMAESRN-LSVQQIRPHS----------------VPSSDYEYI------------------ 1440

Mouse  1046 AIFRESGSTNGSGDEELSGDEEASGGGSGGLEP-PVGSVVV-THG----------PPI---ERAS 1095
            .:.:..||:....|.|:....:.|      |.| ..|:|.: .:|          ||.   :|.|
  Fly  1441 VVVQMEGSSFHREDAEIQRMNDLS------LVPKSTGNVSIGAYGQFYHPLYFQLPPQFYGDRTS 1499

Mouse  1096 CYNSPLGCCSDGKTPSLDSEGSNCPATKAFQG-----------VLELEGVEGQELFYTPEMAD-- 1147
            .|...|..       :|.:||::.|..:...|           .|.|:..|.:|..|:..:..  
  Fly  1500 SYGGFLYF-------TLITEGAHKPLERNILGQYPLVQLHAHSKLLLDFYEYEEFEYSLNVTHRV 1557

Mouse  1148 PKSELFGE---TARSIESTLDDLFRNSDVKKDFWSIRLRELGPGKLVRAIVDVHFDPTTAFQAPD 1209
            |..|.|.:   |:::::       ||:                  |:.|:.::......||...|
  Fly  1558 PLHESFWKYHHTSQAVD-------RNT------------------LMAALQNIRHIFIRAFAFAD 1597

Mouse  1210 VGQALLQQIQVSRPWALAVRRPLREHVRFLDFDWFPTFFTGAATGTTAAVATARATTVSRLSASS 1274
            ..:.:||.:.:..  |:.::                        |:|..:|..    |.|...  
  Fly  1598 FQEVVLQNVHMDA--AIYIK------------------------GSTNLIAKG----VERCKC-- 1630

Mouse  1275 VTPRVYPSYTSRPVGRTTAPLTTRRPPTTTASIDRPRTPGPQRPPKSCDSQPCLHGGTCQDLDSG 1339
              |:.:...:.:..||:   ....|..|...|:......|        .:.||...|...|.|..
  Fly  1631 --PKRFDGLSCQDPGRS---FYRWRNTTIVESVFIEDLIG--------RAAPCHCNGRSSDCDRE 1682

Mouse  1340 KGFSCSCTAGRAGTVCEKVQLPSVPAFKGHSFLAFPTLRAYHTLRLALEFRALETEGLLLYNGNA 1404
            .|...:|.....|..|.:.                                   .||        
  Fly  1683 TGVCQNCRGNTGGDHCHQC-----------------------------------AEG-------- 1704

Mouse  1405 RGKDFLALALLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAPVVGES 1469
                            |..|..|.........|         |.:|::.:|....|||.      
  Fly  1705 ----------------FYGDPNSPHGCQACPCP---------ETNRNFARGCNVWDGEV------ 1738

Mouse  1470 PSGTDGLNLDTKLYVGGLPEEQVATVLDRTSVGIGLKGCIRMLDINNQQLELSDWQRAVVQSSGV 1534
                                                 .|:                         
  Fly  1739 -------------------------------------SCV------------------------- 1741

Mouse  1535 GECGDHPCSPNPCHGGALCQALEAGVFLCQCPPGRFGPTCADEKNPCQPNPCHGSAPCHVLSRG- 1598
                   |.|.  :.|.||:         :|..|.||.........|||..||   |..:.:.| 
  Fly  1742 -------CKPG--YTGRLCE---------RCQAGYFGDPMRYPNTTCQPCNCH---PDGIQTEGC 1785

Mouse  1599 ---GAKCACPLGRSGSFCETVLENAGSRPFLADFNG-----------FSYLEL------KGLHTF 1643
               ..:|.|..|.:|..|:   :....|..|.| ||           ..|:||      :|:|..
  Fly  1786 DVETGRCYCREGVTGLKCD---KCQAERHHLVD-NGCKICDNCTLLLLDYMELVGNKLRRGMHNM 1846

Mouse  1644 E--------RDLGE-KMALEMVFLARGPSGLLLYNGQKTD-----------GKGDFVSLALHNRH 1688
            :        |.|.| :.|.|.            :||:..|           ...|.:.|..|..:
  Fly  1847 DLTGIPAPYRKLSEYESAYEK------------WNGRHWDFSQTKRRLQDYDSADILKLEAHAEN 1899

Mouse  1689 LEFRYDLGKGAAIIRSKEPIALGTWVRVFLERNGRKGALQVGDGPRVLGESPKSRKVPHTMLNL- 1752
            |:|:  ..|..|.|..:|          |..::.|:.|:.......:|     ..::..|:.:| 
  Fly  1900 LKFQ--SRKAVATIGKRE----------FAIKSMREDAVTQQHSVGLL-----RSEILQTLSDLH 1947

Mouse  1753 ---KEPLYVGGAPDFSKLARGAAVASGFDGAIQLVSLRGHQLLTQEHVLRAVDVAPFAGHPCTQA 1814
               |...|: ..|...|.||           ..|.::|.|..:.|.  :|:.             
  Fly  1948 GYGKSAHYL-SLPTALKQAR-----------FYLQAIREHDQMVQG--IRST------------- 1985

Mouse  1815 VDNPC-------LNGGSCIPREATYECLCPGGFSGLHCEKGIVEKSVGDLETL---AFDGRTYIE 1869
              |.|       :...|    :|:::            |.|.:|....||...   ..|.|..::
  Fly  1986 --NDCAWKHFYAMGNAS----DASFD------------ESGRLEMLWRDLNQTNHRVVDMRLQVD 2032

Mouse  1870 YLNAVTESELTNEIPAPETLDSRALFSEKALQ------SNHFELSLRTEATQGLVLWIGKVGERA 1928
            .:..| |:|..:.:.....|..|...|.:.|.      |:|.:... .|..:||:        |.
  Fly  2033 RVQEV-ENEAEDVLEHVRNLSIRVGESHQELDELNQRISDHLDPGY-LEQGEGLL--------RL 2087

Mouse  1929 DYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWLRVRAH-----REHREGSLQVGNE 1983
            ......:::|||.   .|....::|.:|:.|.|.:...||.|     .:|....|...||
  Fly  2088 TVQRQIMLNGHLN---QLDGYRILLNTTLGVKTEQQREVRKHWLPKAEKHASHLLARSNE 2144

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AgrnXP_006538554.1 NtA 46..148 CDD:367356
KAZAL 198..244 CDD:197624 12/65 (18%)
KAZAL 274..319 CDD:197624 12/64 (19%)
Kazal_1 351..391 CDD:333798 8/46 (17%)
KAZAL_FS 423..463 CDD:238052 6/49 (12%)
KAZAL 491..536 CDD:197624 6/44 (14%)
KAZAL 556..601 CDD:197624 14/51 (27%)
KAZAL 621..666 CDD:197624 8/57 (14%)
KAZAL 706..752 CDD:197624 14/72 (19%)
EGF_Lam 795..835 CDD:238012 22/39 (56%)
Laminin_EGF 849..>885 CDD:365839 15/35 (43%)
KAZAL 924..971 CDD:197624 15/94 (16%)
SEA 1121..1245 CDD:214554 20/139 (14%)
EGF 1322..1352 CDD:333761 7/29 (24%)
Laminin_G_1 1389..1520 CDD:333802 13/130 (10%)
Laminin_G_1 1657..1792 CDD:333802 27/149 (18%)
EGF_CA 1814..1846 CDD:238011 4/38 (11%)
Laminin_G_1 1910..2040 CDD:333802 19/79 (24%)
wbNP_723870.1 Laminin_N 164..396 CDD:278484
EGF_Lam 401..450 CDD:238012
TNFRSF <407..507 CDD:304602 12/60 (20%)
EGF_Lam 505..552 CDD:238012 10/50 (20%)
Laminin_EGF 550..597 CDD:278482 12/54 (22%)
Laminin_B 660..798 CDD:278481 29/158 (18%)
EGF_Lam 851..900 CDD:238012 14/75 (19%)
Laminin_EGF <943..971 CDD:278482 8/32 (25%)
VSP 953..1414 CDD:146106 124/525 (24%)
Laminin_EGF 974..1018 CDD:278482 7/56 (13%)
EGF_Lam 1017..1065 CDD:238012 18/64 (28%)
Laminin_EGF 1065..>1105 CDD:278482 9/39 (23%)
EGF_Lam 1150..1197 CDD:238012 26/51 (51%)
Laminin_EGF 1199..1247 CDD:278482 16/47 (34%)
EGF_Lam 1247..1292 CDD:238012 6/44 (14%)
Laminin_EGF 1294..1342 CDD:278482 11/49 (22%)
Laminin_EGF 1340..1392 CDD:278482 9/56 (16%)
Laminin_B 1486..1611 CDD:278481 29/158 (18%)
EGF_Lam 1669..1716 CDD:238012 14/105 (13%)
Laminin_EGF 1718..1767 CDD:278482 17/143 (12%)
EGF_Lam 1772..1819 CDD:238012 15/53 (28%)
CrfC <1933..2267 CDD:223771 53/275 (19%)
Laminin_II 2277..2400 CDD:283628
LamG 2399..>2492 CDD:304605
Laminin_G_2 2616..2755 CDD:280389
Laminin_G_2 2804..2944 CDD:280389
Laminin_G_2 3038..3169 CDD:280389
LamG 3192..3347 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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