DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Agrn and LanA

DIOPT Version :9

Sequence 1:XP_006538554.1 Gene:Agrn / 11603 MGIID:87961 Length:2057 Species:Mus musculus
Sequence 2:NP_476617.1 Gene:LanA / 38723 FlyBaseID:FBgn0002526 Length:3712 Species:Drosophila melanogaster


Alignment Length:2441 Identity:485/2441 - (19%)
Similarity:736/2441 - (30%) Gaps:904/2441 - (37%)


- Green bases have known domain annotations that are detailed below.


Mouse    88 LDGGNKVVIGGFGDPLICDNQVSTGDTRIF-----FVNPAPP-----YLWPAHKNEL-------- 134
            ||..|:..|       :.:::|......:|     :..|:.|     |...|.||:.        
  Fly  1215 LDSQNEATI-------VIESKVDATKPNLFVILVKYYQPSHPKYQVYYTLTAGKNQYDGKFDIQH 1272

Mouse   135 MLNSSLMRITLRNLEEVEFCVEDKPGIHFTAAPSMPPDVCRGML--------------------- 178
            ..:||..|..:|...|..|.::|:  ..||........|....|                     
  Fly  1273 CPSSSGCRGVIRPAGEGSFEIDDE--FKFTITTDRSQSVWLDYLVVVPLKQYNDDLLVEETFDQT 1335

Mouse   179 ------CGFGAVCEPSVEDPGRASCVCKKNVCPAMV-----APVCGSD-ASTYSNECELQRAQCN 231
                  ||     .........||..|||:|.....     |..|..| |.:.|.||.....||.
  Fly  1336 KEFIQNCG-----HDHFHITHNASDFCKKSVFSLTADYNSGALPCNCDYAGSTSFECHPFGGQCQ 1395

Mouse   232 QQRRIRLLRQGPCGSR----DPCANVTCSFGSTCVPSADGQTASCLCPTTCFG------AP---- 282
            .:..:.....|.|.||    ..|....|...:.|.|:    |..|:||....|      ||    
  Fly  1396 CKPNVIERTCGACRSRYYGFPDCKPCKCPNSAMCEPT----TGECMCPPNVIGDLCEKCAPNTYG 1456

Mouse   283 -------DGTVCGSDGV-DYPSECQLLRHACANQEHIFKKFDG-PCDPCQGSMSDLNHICRVNPR 338
                   :...|...|: :..|:|.|....|..:::|    :| .||.|.....:..| |     
  Fly  1457 FHQVIGCEECACNPMGIANGNSQCDLFNGTCECRQNI----EGRACDVCSNGYFNFPH-C----- 1511

Mouse   339 TRHPEMLLRPENC----PAQHTPICGD-DGVTYENDCVMSRIGAARGLLLQKVRSGQCQTRDQC- 397
                      |.|    |.....:|.. ||..:   |..:.:|.            .|   ||| 
  Fly  1512 ----------EQCSCHKPGTELEVCDKIDGACF---CKKNVVGR------------DC---DQCV 1548

Mouse   398 ----------PETCQFNSVCLSRRGRPHCSCDRVTCDGAYR-----------PVCAQDGH--TYD 439
                      |:.|. ...|..:..|         ||.||.           .:...:.|  :..
  Fly  1549 DGTYNLQESNPDGCT-TCFCFGKTSR---------CDSAYLRVYNVSLLKHVSITTPEFHEESIK 1603

Mouse   440 NDCWRQQAE--------------CRQQQTIPPKHQGPCD-----QTPSPCRGAQCAFGATCTVK- 484
            .|.|...|:              .|:.....|.:.|..|     .......|...|:....|.. 
  Fly  1604 FDMWPVPADEILLNETTLKADFTLREVNDERPAYFGVLDYLLNQNNHISAYGGDLAYTLHFTSGF 1668

Mouse   485 NGKAV--------CECQRVCSGGYD-------------------------PVCGSD--------- 507
            :||.:        .|...:....|:                         ||..:|         
  Fly  1669 DGKYIVAPDVILFSEHNALVHTSYEQPSRNEPFTNRVNIVESNFQTISGKPVSRADFMMVLRDLK 1733

Mouse   508 ----GVTYGS---VCELESMACTLGREIRVARRGPCDRCGQCRFGSLCEVETGRCVCPSECVESA 565
                ...|..   |..|..:..||..|       ..|..|:.:|     :...||.||.      
  Fly  1734 VIFIRANYWEQTLVTHLSDVYLTLADE-------DADGTGEYQF-----LAVERCSCPP------ 1780

Mouse   566 QPVCGSDGHT------------------YASECELHVHACTHQISLYVASAGHCQTCGETVCTFG 612
                |..||:                  |...||.:               ||.:||.       
  Fly  1781 ----GYSGHSCEDCAPGYYRDPSGPYGGYCIPCECN---------------GHSETCD------- 1819

Mouse   613 AVCSAGQCVCPRCEHPPPGPVC-------------GS-------------DGVTYLSACELREAA 651
              |:.|  :|.:|:|...|..|             |:             |...:.::||:.|:.
  Fly  1820 --CATG--ICSKCQHGTEGDHCERCVSGYYGNATNGTPGDCMICACPLPFDSNNFATSCEISESG 1880

Mouse   652 CQQQVQIEEARAGP-CEPAECGSGGSGSGED--NACEQELCRQHGGVWDEDSEDGPCVCDFSCQS 713
            .|...:.:....|| ||  .|.:|..|..|.  ..|:.  |...|.:..||...    ||.....
  Fly  1881 DQIHCECKPGYTGPRCE--SCANGFYGEPESIGQVCKP--CECSGNINPEDQGS----CDTRTGE 1937

Mouse   714 VLKSPVCGSDGVTYSTECHLKKARCEARQELYVAAQGACRGPTLAPLLPMASPHCAQTPYGCCQD 778
            .|:   |.::  |:...|:|                                  ||...||    
  Fly  1938 CLR---CLNN--TFGAACNL----------------------------------CAPGFYG---- 1959

Mouse   779 NVTAAQGVGLAGCPSTCHCNPHGSYSGTCDPVTGQCSCRPGVGGLRCDRCEPGFWNFRGIVTDGH 843
                 ..:.|..|.| |.|:..|:.  ||||..|.|:|...|.|.|||||:|..:.|...|    
  Fly  1960 -----DAIKLKNCQS-CDCDDLGTQ--TCDPFVGVCTCHENVIGDRCDRCKPDHYGFESGV---- 2012

Mouse   844 SGCTPCSCDPRGAVRD--DCEQMTGLCSCRPGVAGPKCGQCPDGQALGHLGCEADPTTPVTCVEM 906
             ||..|.|   ||..:  .|:..||.|:|:.||.|.:|.:|    |:.|...|.|..||..|.:.
  Fly  2013 -GCRACDC---GAASNSTQCDPHTGHCACKSGVTGRQCDRC----AVDHWKYEKDGCTPCNCNQG 2069

Mouse   907 HCEFGASCVEEAGFAQCVCPTL-----TCPEANSTKVCGSDGVTYGNECQLKTIACRQRLDISIQ 966
            :.. |..|....|..||:...:     .||  |...:...:|....|.|....:....|:...|.
  Fly  2070 YSR-GFGCNPNTGKCQCLPGVIGDRCDACP--NRWVLIKDEGCQECNNCHHALLDVTDRMRYQID 2131

Mouse   967 SLGPCRESVAPGVSPTSASMTTPRHILSRTLAS---------PHSSLPLSPSTTAHDWPTPLPTS 1022
            |:.....||      |.|..|:.:......||.         ..:|:.||||..|:   :.|.:.
  Fly  2132 SVLEDFNSV------TLAFFTSQKLNYYDQLADELEPKVKLLDPNSVDLSPSKKAN---SELESD 2187

Mouse  1023 PQTVVGTPRSTAATPSDVASLATAIFRESGSTN------------GSGD---------EELSGDE 1066
            .::.......|.|...|:        ||..||.            .|.|         |.||.:.
  Fly  2188 AKSYAKQVNQTLANAFDI--------RERSSTTLGNITVAYDEAVKSADQAKEAIASVEALSKNL 2244

Mouse  1067 EAS-------------------GGGSGGLEP-------------PVGSVVVTHGPPIERASCYNS 1099
            ||:                   .|.|..|.|             .|.::|:......:..:...:
  Fly  2245 EAAASTKIDAALEQAQHILGQINGTSIELTPNEQVLEKARKLYEEVNTLVLPIKAQNKSLNALKN 2309

Mouse  1100 PLGCCSD-----------GKTPSLDSEGSNCPATKAFQGVLELEGVEGQELFYTPEMADPKSELF 1153
            .:|..||           .:..|.|.|..|....|||.. .:.:.|..|:|.....:.|..:.|.
  Fly  2310 DIGEFSDHLEDLFNWSEASQAKSADVERRNVANQKAFDN-SKFDTVSEQKLQAEKNIKDAGNFLI 2373

Mouse  1154 -GE-TARSIESTLDDL------------------------FRNSDVKKDFWSIRLRELGPGKLVR 1192
             |: |...|...||:|                        .:.:|...|....:..||.    ::
  Fly  2374 NGDLTLNQINQKLDNLRDALNELNSFNKNVDEELPVREDQHKEADALTDQAEQKAAELA----IK 2434

Mouse  1193 A--IVDVHFDPT----------TAF----QAPDVGQALLQQIQVSRPWALAVRRPLREHVRFLDF 1241
            |  :...:.|.|          ||:    :|.:..|.|.|....:...|......:.|.....| 
  Fly  2435 AQDLAAQYTDMTASAEPAIKAATAYSGIVEAVEAAQKLSQDAISAAGNATDKTDGIEERAHLAD- 2498

Mouse  1242 DWFPTFFTGAATGTTAAVATAR-----------------ATTVSRLSA-SSVTPR---------- 1278
                       ||:|..:..||                 |..|.::|| ::.|..          
  Fly  2499 -----------TGSTDLLQRARQSLQKVQDDLEPRLNASAGKVQKISAVNNATEHQLKDINKLID 2552

Mouse  1279 VYPSYTSRPVGRTTAPLTTRRPPTTTAS--------IDRPRTPGPQRPPKSCDSQPCLHGGTCQD 1335
            ..|:.:.|.:.:.:         ...||        :.....|...:.||..:.   .| |..:|
  Fly  2553 QLPAESQRDMWKNS---------NANASDALEILKNVLEILEPVSVQTPKELEK---AH-GINRD 2604

Mouse  1336 LD-SGKGFS--------CSCTAGRAGTVCEKV----------------QLPSVPA---------- 1365
            || :.|..|        ...:..:...:.|.:                ::.::.|          
  Fly  2605 LDLTNKDVSQANKQLDDVEGSVSKLSELAEDIEEQQHRVGSQSRQLGQEIENLKAQVEAARQLAN 2669

Mouse  1366 -------FKGHSFLAFPT-----LRAYHTLRLALEFRALETEGLLLYNGN-----ARGKDFLALA 1413
                   ||..:.|...|     |.|..| .|:..||..|..|.|||.||     .:..||:|:.
  Fly  2670 SIKVGVNFKPSTILELKTPEKTKLLATRT-NLSTYFRTTEPSGFLLYLGNDNKTAQKNNDFVAVE 2733

Mouse  1414 LLDGHVQFRFDTGSGPAVLTSLVPVEPGRWHRLELSRHWRQGTLSVDGEAP---VVGESPSG-TD 1474
            :::|:.....|.|:||..:||...|..|||::..:.|......|::..|.|   ||..|.|| .:
  Fly  2734 IVNGYPILTIDLGNGPERITSDKYVADGRWYQAVVDRMGPNAKLTIREELPNGDVVEHSKSGYLE 2798

Mouse  1475 G----LNLD--TKLYVGGLPEEQVATVLDRTSVGI------------GLKGCIRMLDINNQQLEL 1521
            |    |::|  ::|:|||.|             ||            ...|.|..|.|.::.:.|
  Fly  2799 GSQNILHVDKNSRLFVGGYP-------------GISDFNAPPDLTTNSFSGDIEDLKIGDESVGL 2850

Mouse  1522 SDWQRAVVQSSGVGECGDHPCSPNPCHGGALCQALEAGVFLCQCPPGRFGPTCADEKNPCQPNPC 1586
              |.......:..|                   |.|..|.|             ::|.|.     
  Fly  2851 --WNFVYGDDNDQG-------------------ARERDVLL-------------EKKKPV----- 2876

Mouse  1587 HGSAPCHVLSRGGAKCACPLGRSGSFCETVLENAGSRPFLADFNGFSYLELKGLHTFERDLGEKM 1651
                                             .|.|     |.|..|::|..    ..:|..:.
  Fly  2877 ---------------------------------TGLR-----FKGNGYVQLNA----TSNLKSRS 2899

Mouse  1652 ALEMVFLA--RGPSGLLLYNGQKTDGKGDFVSLALHNRHLEFRYDLGKGAAI-IRSKEPIALGTW 1713
            :::..|.|  ...:|||.:.|:..    .::|:.:.:..:.|...||:|..: ..|::......|
  Fly  2900 SIQFSFKADKDTSNGLLFFYGRDK----HYMSIEMIDGAIFFNISLGEGGGVQSGSQDRYNDNQW 2960

Mouse  1714 VRVFLERNGRKGALQVGD-------GPRVLG-ESPKSRKVPHTMLNLKEPLYVGGAPDFSKLARG 1770
            .:|..||..|.|.|:|.|       .|.... |.||.|:           ||.||.|  .:|...
  Fly  2961 HKVQAERENRNGLLKVDDIVISRTNAPLEADLELPKLRR-----------LYFGGHP--RRLNTS 3012

Mouse  1771 AAVASGFDGAIQLVSLRGHQLLTQEHVLRAVDVAPFAGHPCTQAVDNPCLNGGSCIPREATYECL 1835
            .::...|||.|                                  ||..:|.|..   :.| |.:
  Fly  3013 ISLQPNFDGCI----------------------------------DNVVINQGVV---DLT-EYV 3039

Mouse  1836 CPGGFSGLHCEKGIVEKSVGDLETLAFDGRTYIEYLNAVTESELTNEIPAPETLDSRALFSEKAL 1900
            ..||     .|:|...|.           .|.:.|              ||.......:.:..:.
  Fly  3040 TGGG-----VEEGCSAKF-----------STVVSY--------------APHEYGFLRMNNVSSD 3074

Mouse  1901 QSNHFELSLRTEATQGLVLWIGKVGERADYMALAIVDGHLQLSYDLGSQPVVLRSTVKVNTNRWL 1965
            .:.|..|..:|....| ||:.....:::..:.|::.||.|:|: .:|||.|:....:....:..:
  Fly  3075 NNLHVVLHFKTTQPNG-VLFYAANHDQSSTIGLSLQDGLLKLN-SMGSQLVIDDRILNDGEDHVV 3137

Mouse  1966 RVRAHREHREGSLQ-----VGNEAPVTGSSPLGATQ--LDTDGALWLGGL---QKLPVGQALPKA 2020
            .|    :|.:|.|:     |.|:.       ||:.|  :...|.::..||   .:.|.......|
  Fly  3138 TV----QHTQGELRLTVDDVDNKR-------LGSPQPLILEGGDIFFAGLPDNYRTPRNALASLA 3191

Mouse  2021 YGTGFVGCLRDVVVGHRQLHLLEDAVTK-PELRPCP 2055
            |   ||||:.||.|....::....|..| ..:..||
  Fly  3192 Y---FVGCISDVTVNEEIINFANSAEKKNGNINGCP 3224

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
AgrnXP_006538554.1 NtA 46..148 CDD:367356 16/77 (21%)
KAZAL 198..244 CDD:197624 14/51 (27%)
KAZAL 274..319 CDD:197624 13/63 (21%)
Kazal_1 351..391 CDD:333798 7/44 (16%)
KAZAL_FS 423..463 CDD:238052 11/66 (17%)
KAZAL 491..536 CDD:197624 11/85 (13%)
KAZAL 556..601 CDD:197624 9/62 (15%)
KAZAL 621..666 CDD:197624 13/71 (18%)
KAZAL 706..752 CDD:197624 7/45 (16%)
EGF_Lam 795..835 CDD:238012 18/39 (46%)
Laminin_EGF 849..>885 CDD:365839 14/37 (38%)
KAZAL 924..971 CDD:197624 9/51 (18%)
SEA 1121..1245 CDD:214554 30/165 (18%)
EGF 1322..1352 CDD:333761 7/38 (18%)
Laminin_G_1 1389..1520 CDD:333802 46/157 (29%)
Laminin_G_1 1657..1792 CDD:333802 36/145 (25%)
EGF_CA 1814..1846 CDD:238011 8/31 (26%)
Laminin_G_1 1910..2040 CDD:333802 35/139 (25%)
LanANP_476617.1 LamNT 18..271 CDD:214532
EGF_Lam 272..>314 CDD:238012
EGF_Lam 332..389 CDD:238012
EGF_Lam 402..443 CDD:238012
EGF_Lam 448..491 CDD:238012
Laminin_EGF 495..543 CDD:278482
Laminin_EGF 541..589 CDD:278482
Laminin_EGF 587..634 CDD:278482
EGF_Lam 631..673 CDD:238012
Laminin_EGF 677..729 CDD:278482
Laminin_EGF 732..782 CDD:278482
EGF_Lam 785..828 CDD:238012
CBM6-CBM35-CBM36_like 831..966 CDD:271143
Laminin_EGF 1375..1423 CDD:278482 13/47 (28%)
EGF_Lam 1420..1457 CDD:238012 10/40 (25%)
Laminin_EGF 1466..1516 CDD:278482 15/69 (22%)
Laminin_EGF 1514..1562 CDD:278482 12/65 (18%)
LamB 1632..1760 CDD:214597 18/127 (14%)
Laminin_EGF <1775..1801 CDD:278482 7/35 (20%)
EGF_Lam 1808..1851 CDD:238012 13/68 (19%)
EGF_Lam 1859..1907 CDD:214543 12/49 (24%)
EGF_Lam 1916..1968 CDD:238012 16/105 (15%)
EGF_Lam 1969..2015 CDD:238012 22/53 (42%)
EGF_Lam 2016..>2054 CDD:238012 15/44 (34%)
EGF_Lam 2063..>2097 CDD:238012 7/34 (21%)
Laminin_I 2129..2385 CDD:283627 54/273 (20%)
Tar 2278..2662 CDD:223910 65/413 (16%)
Laminin_II 2566..2700 CDD:283628 21/147 (14%)
LamG 2674..2843 CDD:238058 53/182 (29%)
LamG 2878..3029 CDD:238058 45/210 (21%)
LamG 3078..3205 CDD:214598 37/142 (26%)
LamG 3349..3512 CDD:238058
LamG 3535..3689 CDD:238058
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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