Protein Alignment WDFY2 and Wdfy2

DIOPT Version :10

• Sequence 1: NP_443182.1
• Gene: WDFY2 / 115825
• HGNCID: 20482
• Length: 400
• Species: Homo sapiens
• Sequence 2: NP_609400.1
• Gene: Wdfy2 / 34425
• FlyBaseID: FBgn0032246
• Length: 408
• Species: Drosophila melanogaster
• Alignment Length: 406
• Identity: 203/406 - (50%)
• Similarity: 297/406 - (73%)
• Gaps: 8/406 - (1%)

Human     1 MAAEIQPKPLT--------RKPILLQRMEGSQEVVNMAVIVPKEEGVISVSEDRTVRVWLKRDSG 57
            |||||:|...|        :||.||.::|||.:.||.|:::|.|.||||||:|:|||||||||||
  Fly     1 MAAEIKPAQRTNNDRFNTSKKPELLSKLEGSSDDVNAAILIPGENGVISVSDDKTVRVWLKRDSG 65

Human    58 QYWPSVYHAMPSPCSCMSFNPETRRLSIGLDNGTISEFILSEDYNKMTPVKNYQAHQSRVTMILF 122
            |||||:...|||.|:.:.:..|:|.|.:|.:|||::::.||||.|:::.:::|.:||:||..::|
  Fly    66 QYWPSICQYMPSGCTAIEYVSESRHLYVGQENGTVTQYALSEDCNRLSFLRDYLSHQARVMAVVF 130

Human   123 VLELEWVLSTGQDKQFAWHCSESGQRLGGYRTSAVASGLQFDVETRHVFIGDHSGQVTILKLEQE 187
            ....:|:||.|:|||||:||:|||:|:|||......:.||||...::.|:|||:||:|:|:.:.:
  Fly   131 SKTHKWILSAGKDKQFAYHCTESGKRVGGYNFETPCTALQFDALAKYAFVGDHAGQITMLRCDVQ 195

Human   188 NCTLVTTFRGHTGGVTALCWDPVQRVLFSGSSDHSVIMWDIGGRKGTAIELQGHNDRVQALSYAQ 252
            ...|:|||.||:..:..|.|....::||||:.|.||::||:||::||..|||||:::|.|||||.
  Fly   196 GVQLITTFNGHSAEIRCLKWVEGPQLLFSGACDQSVLVWDVGGKRGTIYELQGHSNKVSALSYAN 260

Human   253 HTRQLISCGGDGGIVVWNMDVERQETPEWLDSDSCQKCDQPFFWNFKQMWDSKKIGLRQHHCRKC 317
            ||:||||||.|..:|.|.|:..|:|.|.|:|:::||.|.:||||||:.|.|.|::|:||||||.|
  Fly   261 HTQQLISCGEDSVVVFWEMNAMRKEVPGWVDTNNCQLCSRPFFWNFRSMMDQKQLGIRQHHCRHC 325

Human   318 GKAVCGKCSSKRSSIPLMGFEFEVRVCDSCHEAITDEERAPTATFHDSKHNIVHVHFDATRGWLL 382
            |||||..||:.|.:||:|||||:||.||.|::.:...||...|:|:|:||:||::..|..|..||
  Fly   326 GKAVCDNCSTNRINIPIMGFEFDVRTCDPCYKQLQTVERPSLASFNDAKHSIVYMDLDEDRKRLL 390

Human   383 TSGTDKVIKLWDMTPV 398
            |.|.|::||:||::.:
  Fly   391 TVGQDRLIKIWDLSNI 406

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
WDFY2	NP_443182.1	WD40	<16..272	CDD:441893	128/255 (50%)
		WD 1	22..61		27/38 (71%)
		WD40 repeat	27..64	CDD:293791	28/36 (78%)
		WD 2	66..105		16/38 (42%)
		WD40 repeat	72..132	CDD:293791	20/59 (34%)
		WD 3	112..150		20/37 (54%)
		WD 4	153..192		12/38 (32%)
		WD40 repeat	159..197	CDD:293791	16/37 (43%)
		WD 5	197..236		17/38 (45%)
		WD40 repeat	203..240	CDD:293791	17/36 (47%)
		WD 6	240..279		22/38 (58%)
		WD40 repeat	245..283	CDD:293791	22/37 (59%)
		FYVE_WDFY1_like	279..348	CDD:277258	42/68 (62%)
		WD40 repeat	321..363	CDD:293791	20/41 (49%)
		WD 7	364..399		16/35 (46%)
		WD40 repeat	369..395	CDD:293791	12/25 (48%)
Wdfy2	NP_609400.1	WD40	24..279	CDD:475233	128/254 (50%)
		WD40 repeat	35..72	CDD:293791	28/36 (78%)
		WD40 repeat	80..117	CDD:293791	12/36 (33%)
		WD40 repeat	125..161	CDD:293791	19/35 (54%)
		WD40 repeat	166..205	CDD:293791	16/38 (42%)
		WD40 repeat	211..248	CDD:293791	17/36 (47%)
		WD40 repeat	253..283	CDD:293791	18/29 (62%)
		FYVE_WDFY1_like	287..356	CDD:277258	42/68 (62%)
		WD40 repeat	324..371	CDD:293791	24/46 (52%)