DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment RASGRP4 and rasgrp4

DIOPT Version :9

Sequence 1:	NP_733749.1	Gene:	RASGRP4 / 115727	HGNCID:	18958	Length:	673	Species:	Homo sapiens
Sequence 2:	XP_005173714.1	Gene:	rasgrp4 / 558453	ZFINID:	ZDB-GENE-050419-110	Length:	725	Species:	Danio rerio

Alignment Length:	735	Identity:	337/735 - (45%)
Similarity:	449/735 - (61%)	Gaps:	91/735 - (12%)

- Green bases have known domain annotations that are detailed below.

Human     1 MNRKDSK--RKSHQECTGKIGGRGRPRQVRRHKTCPSPREISKVMASMNLGLLSEGGCSEDELLE 63
            ||||:||  |||.||     ||....|.|:|..||||.:|||:.:.|.. ...|....|.|||:.
Zfish     6 MNRKESKSSRKSRQE-----GGIKSRRPVQRRMTCPSAQEISRALQSPP-AHASFRSASLDELIL 64

Human    64 KCIQSFDSAGSLCHEDHMLNMVLAMHSWVLPSADLAARLLTSYQKATGDTQELRRLQICHLVRYW 128
            :|:..|||.|.|.....:::|.|.||:||:||...|.:||:.|:....:.:..||.||||.:|.|
Zfish    65 RCLHCFDSDGKLNRGTQLVSMTLMMHNWVVPSHIFAHKLLSLYKDCPAEKRGQRRPQICHFIRQW 129

Human   129 LMRHPEVMHQDPQLEEVIGRFWATVAREGNSAQRRLGDSSDLLSPGGPGPPLPMS---SPGLGKK 190
            :.:...:...||.||:.:|..||.|:.||.::..:|.::..:      .||:.:|   || |.||
Zfish   130 ISQFRLMFEMDPLLEKAMGDLWALVSAEGTNSHHQLINTPYI------NPPVNISQTPSP-LVKK 187

Human   191 RKVSLLFDHLETGELAQHLTYLEFRSFQAITPQDLRSYVLQGSVRGCPALEGSVGLSNSVSRWVQ 255
            |||||||||:|..|:|:||:||||::|..::..|.||||:.||||..||||.||.|.|.||:|||
Zfish   188 RKVSLLFDHMEPDEMAEHLSYLEFKNFCNVSFLDYRSYVVHGSVRDNPALERSVMLCNGVSQWVQ 252

Human   256 VMVLSRPGPLQRAQVLDKFIHVAQRLHQLQNFNTLMAVTGGLCHSAISRLKDSHAHLSPDSTKAL 320
            :|:|:|....|||:|..|||||||:|..||||||||||.||||||:||||||:.:.||.|.||.|
Zfish   253 LMILNRHTSQQRAEVFTKFIHVAQKLRSLQNFNTLMAVIGGLCHSSISRLKDTASLLSSDVTKTL 317

Human   321 LELTELLASHNNYARYRRTWAGCAGFRLPVLGVHLKDLVSLHEAQPDRLPDGRLHLPKLNNLYLR 385
            .||||||:|::||:.|||.::.|.||::|:||||||||:||:||.||.|.|.:::|.||.:||..
Zfish   318 SELTELLSSYSNYSNYRRVYSECTGFKVPILGVHLKDLISLNEALPDYLEDDKINLGKLQHLYSN 382

Human   386 LQELVALQGQHPPCSANEDLLHLLTLSLDLFYTEDEIYELSYAREPRCPKSLPPSPFNAPLVVEW 450
            :.:|:|:....||..||:||||||||||||:||||||||||||:||:.||..|.:|...|:|.||
Zfish   383 ISDLLAIHDCTPPFEANKDLLHLLTLSLDLYYTEDEIYELSYAKEPKNPKIQPVAPVKPPVVAEW 447

Human   451 APGVTPKPDRVTLGRHVEQLVESVFKNYDPEGRGTISQEDFERLSGNFPFA-CHGLHPPPRQGRG 514
            ..||||:.|..|:.:||:|:|:|:.||||....|.||.|:||:::.||||: |  .|...|:  |
Zfish   448 GSGVTPRLDPATISKHVKQMVDSIMKNYDLNMDGYISLEEFEKIAANFPFSFC--THESDRE--G 508

Human   515 SFSREELTGYLLRASAICSKLG--LAFLHTFHEVTFRKPTFCDSCSGFLWGVTKQGYRCRECGLC 577
            ..||||:|.|.:|..::|:|||  |..||.|||.|:::|||||:|.||||||.||||.|::||:.
Zfish   509 EISREEITSYFMRGMSVCAKLGFNLHNLHNFHETTYKRPTFCDTCGGFLWGVIKQGYHCKDCGVN 573

Human   578 CHKHCRDQVKVECKKRPGAKGDAGPPGAPVPSTPAPHASC------------------------- 617
            |||||:|.|.:||.||......:      .|.||.|.:..
Zfish   574 CHKHCKDVVGMECLKRLQVNSSS------CPCTPGPVSGLHTKGNSWSEFSQSFQSGSEEEAFVF 632

Human   618 --GSEENHS------------YTL---SLEPETGCQLRHAWT---------QTESPHPSWE-TDT 655
              |:|..||            .||   |.:.|.|     .||         .::..||..| :.|
Zfish   633 PNGNESEHSKGQTSSDSDAEAATLSDRSTQTEPG-----VWTPVAKRKDRLHSQKQHPPLEKSAT 692

Human   656 VPCPVMD---PPSTASSKLD 672
            :|..|..   |.|....|:|
Zfish   693 LPARVRGSSAPSSLLQEKMD 712

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
RASGRP4	NP_733749.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..30		15/30 (50%)
		REM	57..164	CDD:100121	40/106 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	160..187		6/29 (21%)
		RasGEF	197..432	CDD:214539	146/234 (62%)
		C1	541..590	CDD:197519	31/48 (65%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	593..621		6/54 (11%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	639..673		12/47 (26%)
rasgrp4	XP_005173714.1	REM	58..162	CDD:100121	40/103 (39%)
		RasGEF	194..430	CDD:214539	147/235 (63%)
		EF-hand_7	473..519	CDD:290234	23/49 (47%)
		EFh	475..524	CDD:298682	23/52 (44%)
		C1_1	537..586	CDD:278556	31/48 (65%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C194324051
Domainoid	1	1.000	133	1.000	Domainoid score	I20264
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
NCBI	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D177873at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR23113
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X813
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	1	1.500	-	-
	8	8.450